Herbicide tolerant plants such as Roundup-Ready soybean contain residues of glyphosate herbicide. These residues are considered safe and previous animal-feeding-studies have failed to find negative effects related to such chemical residues. The present study tests 8 experimental soy- meal diets as feed in groups (each containing 20 individuals) of test-animals (D. magna). The diets have different ...

In the human retina, rod and cone cells detect incoming light with a molecule called rhodopsin. After rhodopsin molecules are activated (by photon impact), these molecules activate the rest of the signalling process for a brief period of time until they are deactivated by a multistage process. First, active rhodopsin is phosphorylated multiple times. Following this, they are further inhibited by the ...

<p><i>Objectives</i>: In vivo evaluations of a gonadotropin releasing hormone-receptor single photon emission computed tomography radiotracer for non-invasive detection of gonadotropin releasing homone-receptors in brain.</p> <p><i>Results</i>: We have used a simple, robust and high-yielding procedure to radiolabel an alpha-halogenated bioactive compound with high radiochemical yield. Literature ...

The mucus layer covering all mucosal surfaces in our body is the first barrier encountered by drugs before their potential absorption through epithelial tissues, and could thus affect the drugs’ permeability and their effectiveness. Therefore, it is of key importance to have in vitro permeability models that can mimic this specific environment. For this purpose, the novel mucus phospholipid vesicle-based ...

<p><I>Objectives</I>: The main objective was to investigate Y-site compatibility of intravenous drugs with one standard total parenteral nutrition (TPN) admixture for preterm infants. Since micro-precipitation was observed in the water phase after addition of trace elements, the concentration effect on micro-precipitation formation developed as a sub-goal.</p> <p><I>Methods</I>: Seven drugs ...

Cell-free permeation systems are gaining interest in drug discovery and development as tools to obtain a reliable prediction of passive intestinal absorption without the disadvantages associated with cell- or tissue-based permeability profiling. Depending on the composition of the barrier, cell-free permeation systems are classified into two classes including (i) biomimetic barriers which are ...

The aim of this study was to prepare and optimize a novel type of in situ gel-forming solid dosage form (gfSDF) to be used in the treatment of mucosal/skin ulcerations. For this purpose, a simple but reliable syringe-based hot melt/moulding method was employed. Chloramphenicol (antibiotic) and ibuprofen (anti-inflammatory) were chosen as model active pharmaceutical ingredients (APIs) to be loaded ...

<i>Hovedbudskap</i>: Mattilsynet og Direktoratet for naturforvalting (DN) ber Vitenskapskomiteen for mattrygghet om å vurdere den genmodifiserte bomullslinjen MON 15985 til import, prosessering, og til bruk i næringsmidler og fôrvarer. Søknaden gjelder ikke dyrking. Monsanto søkte opprinnelig om godkjenning av bomullslinjen i 2005, men søknaden ble trukket og erstattet av vedlagte søknad i 2008. I ...

There is urgent need to develop novel treatment strategies to reduce antimicrobial resistance. Collateral sensitivity (CS), where resistance to one antimicrobial increases susceptibility to other drugs, might enable selection against resistance during treatment. However, the success of this approach would depend on the conservation of CS networks across genetically diverse bacterial strains. Here, ...

Den 19. september 2012 ble det publisert en artikkel i det tyske tidsskriftet «Food and Chemical Toxicology» som vakte oppmerksomhet i store deler av verden. Artikkelen bygger på en toårig fôringsstudie med rotter og konkluderer med en antatt økt hyppighet for ulike svulstdannelser og nyrelidelser blant dyrene knyttet til den genmodifiserte maisen NK603 og plantevernmidlet Roundup som inneholder ...