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dc.contributor.authorLe Moëne, Olivia
dc.contributor.authorÅgmo, Anders j
dc.date.accessioned2019-01-31T13:03:59Z
dc.date.available2019-01-31T13:03:59Z
dc.date.issued2018-11-06
dc.description.abstractEstrogen receptors (ERs) are involved in sexual as well as non-sexual behaviors. In the present study we assessed the effects of stimuli inducing positive or negative affect on sociosexual, exploratory and fear-related behaviors of female rats housed in groups (4 females, 3 males) in a seminatural environment. Ovariectomized females were treated with oil, 17β‑estradiol benzoate (EB, 18 μg/kg), the ERα agonist propylpyrazoletriol (PPT), or the ERβ agonist diarylpropionitrile (DPN) (both 2 × 10 mg/rat). On the test day, the females were exposed to a sequence of events consisting of lavender odor, Mozart's Sonata for Two Pianos K448, chocolate pellets, white noise and fox odor (2,3,5‑Trimethyl‑3‑thiazoline, TMT). All these events are known to induce positive or negative affect. Behavior was carefully observed from the video record. White noise suppressed sexual behaviors and reduced the time spent in the open area of the environment. TMT had no consistent effect whereas exposure to music caused avoidance of the open area. Exposure to chocolate increased exploratory and social behavior. Lavender odor enhanced exploratory behavior. PPT and EB stimulated sexual behaviors, whereas DPN was ineffective. Co-occurrence analyses of the sequence of behavioral patterns revealed that PPT and EB consistently belonged to clusters different from oil and DPN, whereas DPN was separate from oil only under fear-inducing experimental conditions. These data, from a procedure with external validity, confirm that the ERα is crucial for sexual behaviors, that these behaviors are reduced under stressful conditions, and that the ERβ may have some role in fear-related behaviors.en_US
dc.description.sponsorshipFaculty of Health Sciences, University of Tromsøen_US
dc.descriptionSubmitted manuscript version. Published version available at <a href=https://doi.org/10.1016/j.yhbeh.2018.10.013> https://doi.org/10.1016/j.yhbeh.2018.10.013</a>.en_US
dc.identifier.citationLe Moëne, O. & Ågmo, A.J. (2018). Behavioral responses to emotional challenges in female rats living in a seminatural environment: The role of estrogen receptors. <i>Hormones and Behavior</i>, 106, 162-177. https://doi.org/10.1016/j.yhbeh.2018.10.013en_US
dc.identifier.cristinIDFRIDAID 1638061
dc.identifier.doi10.1016/j.yhbeh.2018.10.013
dc.identifier.issn0018-506X
dc.identifier.issn1095-6867
dc.identifier.urihttps://hdl.handle.net/10037/14573
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalHormones and Behavior
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Social science: 200::Psychology: 260en_US
dc.subjectVDP::Samfunnsvitenskap: 200::Psykologi: 260en_US
dc.subjectSeminatural environmenten_US
dc.subjectSexual behavioren_US
dc.subjectSocial behavioren_US
dc.subjectFearen_US
dc.subjectPositive emotionen_US
dc.subjectCo-occurrence analysisen_US
dc.subjectPropylpyrazoletriolen_US
dc.subjectDiarylpropionitrileen_US
dc.titleBehavioral responses to emotional challenges in female rats living in a seminatural environment: The role of estrogen receptorsen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US


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