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dc.contributor.authorObuobi, Sybil Akua Okyerewa
dc.contributor.authorSkalko-Basnet, Natasa
dc.date.accessioned2020-07-17T07:57:38Z
dc.date.available2020-07-17T07:57:38Z
dc.date.issued2020-07-08
dc.description.abstractConventional antibiotic therapy is often challenged by poor drug penetration/accumulation at infection sites and poses a significant burden to public health. Effective strategies to enhance the therapeutic efficacy of our existing arsenal include the use of nanoparticulate delivery platforms to improve drug targeting and minimize adverse effects. However, these nanocarriers are often challenged by poor loading efficiency, rapid release and inefficient targeting. Nucleic acid hybrid nanocarriers are nucleic acid nanosystems complexed or functionalized with organic or inorganic materials. Despite their immense potential in antimicrobial therapy, they are seldom utilized against pathogenic bacteria. With the emergence of antimicrobial resistance and the associated complex interplay of factors involved in antibiotic resistance, nucleic acid hybrids represent a unique opportunity to deliver antimicrobials against resistant pathogens and to target specific genes that control virulence or resistance. This review provides an unbiased overview on fabricating strategies for nucleic acid hybrids and addresses the challenges of pristine oligonucleotide nanocarriers. We report recent applications to enhance pathogen targeting, binding and control drug release. As multifunctional next-generational antimicrobials, the challenges and prospect of these nanocarriers are included.en_US
dc.identifier.citationObuobi SAO, Skalko-Basnet N. Nucleic acids hybrids as advanced antibacterial nanocarriers. Pharmaceutics. 2020;12:643en_US
dc.identifier.cristinIDFRIDAID 1819051
dc.identifier.doi10.3390/pharmaceutics12070643
dc.identifier.issn1999-4923
dc.identifier.urihttps://hdl.handle.net/10037/18876
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalPharmaceutics
dc.relation.projectIDEU: Marie Sklodowska-Curie grant No. 834811en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/834811/EU/DNA nanohydrogel loaded Liposomal formulations for high loading efficiency of antimicrobial drugs against intracellular bacterial and topical biofilm infections/NANOZID/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Pharmacology: 728en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Farmakologi: 728en_US
dc.titleNucleic acids hybrids as advanced antibacterial nanocarriersen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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