Mastergradsoppgaver i molekylær bioteknologi

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  • Binding mode of novel multimodal serotonin transporter compounds in 5-hydroxytryptamine receptors 

    Bøgwald, Isak Andreas (Master thesis; Mastergradsoppgave, 2016-06-01)
    Antidepressants are the most common treatment of depression, one of the leading causes of suicide and disability worldwide. Currently marketed antidepressants have certain limitations; they have a delayed response time, only about 1/3 of the patients respond to the first agent prescribed, and many of them produce side effects that reduce the quality of life. The need for more efficacious and ...

  • The expression of miR-21 in prostate cancer measured by in situ hybridization and its relevance as a diagnostic biomarker 

    Melbø-Jørgensen, Christian Nordahl (Master thesis; Mastergradsoppgave, 2012-12-15)
    Background: Micro RNAs (miRNA) are a novel class of molecular regulators that have gained considerable attention in cancer research. Multiple studies in recent time have reported altered miRNA regulation in most cancers by deregulating of oncogenes and tumour suppressor genes. Additionally, certain tumours are represented by specific miRNA expression files. Prostate cancer is a markedly heterogeneous ...

  • Structure, function and ligand interactions of the ecdysone receptor from Daphnia magna 

    Evenseth, Linn Mari (Master thesis; Mastergradsoppgave, 2014-06-02)
    Background: Endocrine disruptors are of an increasing concern to the global environment due to their ability to modulate endocrine processes and cause adverse apical effects. Invertebrates are important species in the aquatic environment and are a central subject for toxicological testing, but the effects of endocrine disruptors (EDs) in invertebrates are limited due to less knowledge concerning the ...

  • mir-34a targets cell cycle genes CCND1 (cyclin D1) and MYCN, while mir-21 does not target PTEN and PDCD4 in neuroblastoma 

    Utnes, Peter Andree (Master thesis; Mastergradsoppgave, 2013-06-03)
    Neuroblastoma is an embryonal cancer of the post-sympathetic nervous system and is the most frequent extra-cranial solid tumor in childhood. Two important microRNAs, the tumor suppressor mir-34a and the oncogenic mir-21, have been found to increase during MYCN-knockdown induced differentiation. However their distinct roles are not clear. This thesis employs a method to identify the mRNA targets of ...

  • Establishing a method for RNA immunoprecipitation to study interactions between long non-coding RNAs and proteins 

    Brun, Elsebeth Sophie (Master thesis; Mastergradsoppgave, 2012-12-17)
    Long non-coding RNAs (lncRNAs) are involved in several important biological processes, and several lncRNAs have been associated with human diseases, particularly cancer. LncRNAs regulate gene expression at different levels. LncRNAs exert their functions through interactions with DNA, RNA or proteins. In this study, we established a method for investigating interactions between lncRNAs and protein ...

  • Functional characterization of alpha- mannosidosis associated sequence variants 

    Nguyen, Lam Van (Master thesis; Mastergradsoppgave, 2008-12-24)
    Alpha-mannosidosis is a rare autosomal recessive lysosomal-storage disorder resulting from deficiency of lysosomal alpha-mannosidase activity. The disease shows a wide range of clinical phenotypes caused by intracellular accumulation of mannose-containing oligosaccharides, which ultimately may lead to mental retardation, hearing loss, skeletal changes and immune deficiency. Lysosomal alpha-mannosidase ...

  • Purification of the recombinantly produced Helicobacter pylori antigens NAP and FlaA 

    Lea, Ingrid (Master thesis; Mastergradsoppgave, 2008-06-01)
    Helicobacter pylori is a Gram-negative flagellated bacterium that infects the stomach of around 50 % of the worlds population, and can give rise to serious disease such as chronic gastritis, duodenal ulcer and stomach cancer. The current treatment against H. pylori, consisting of a combination of a proton pump inhibitor and two different antibiotics, is effective but has several drawbacks such as ...

  • Regulation of prostanoid effects in whole blood : immediate-early anti-inflammatory effects of prostaglandin E2 

    Phung, Danh Thanh (Master thesis; Mastergradsoppgave, 2008-06-01)
    To understand the regulation of the pathophysiological processes, such as inflammation, thrombosis and atherosclerosis, it is very important to characterize the interactions between circulating cells and which molecules that contributes to and promote these interactions. As a part of this, the role of eicosanoids in cell-cell interactions in whole blood ex vivo and isolated blood cells are investigated. ...

  • A study of regulatory small RNAs in Vibrio salmonicida: construction of a knock-out mutant and a cDNA library 

    Nyrud, May Liss Julianne (Master thesis; Mastergradsoppgave, 2008-06-01)
    The marine fish pathogen Vibrio salmonicida is the causative agent for vibriosis in Atlantic salmon (Salmo salar L.), Rainbow trout (Oncorhynchus mykiss) and Atlantic cod (Gadus morhua L.). V. salmonicidas virulence is regulated by Quorum sensing (QS) systems, which includes important regulatory small RNAs (sRNAs). sRNAs have the last years been identified in large numbers, and mostly in pathogenic ...

  • Studies of genes potentially involved in the induction of flowering in Festuca pratensis (Huds.) 

    Henriksen, Hanne F. (Master thesis; Mastergradsoppgave, 2006-06-08)
    Many plants in northern regions require a period of low temperatures and short days (called vernalisation) during the winter season to initiate the flowering process. In this experiment, some genes thought to be involved in vernalisation response and induction of flowering in meadow fescue (Festuca pratensis) has been investigated. The genes were chosen based on their possible contribution in the ...