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dc.contributor.authorKreis, Isabel Viola
dc.contributor.authorZhang, Lei
dc.contributor.authorMoritz, Steffen
dc.contributor.authorPfuhl, Gerit
dc.date.accessioned2021-11-26T09:54:54Z
dc.date.available2021-11-26T09:54:54Z
dc.date.issued2021
dc.description.abstractAberrant attribution of salience to in fact little informative events might explain the emergence of positive symptoms in schizophrenia and has been linked to belief uncertainty. Uncertainty is thought to be encoded by neuromodulators, including norepinephrine. However, norepinephrinergic encoding of uncertainty, measured as task-related pupil dilation, has rarely been explored in schizophrenia. Here, we addressed this question by comparing individuals with a disorder from the schizophrenia spectrum to a non-psychiatric control group on behavioral and pupillometric measures in a probabilistic prediction task, where different levels of uncertainty were introduced. Behaviorally, patients performed similar to controls, but their belief uncertainty was higher, particularly when instability of the task environment was high, suggesting an increased sensitivity to this instability. Furthermore, while pupil dilation scaled positively with uncertainty, this was less the case for patients, suggesting aberrant neuromodulatory regulation of neural gain, which may hinder the reduction of uncertainty in the long run. Together, the findings point to abnormal uncertainty processing and norepinephrinergic signaling in schizophrenia, potentially informing future development of both psychopharmacological therapies and psychotherapeutic approaches that deal with the processing of uncertain information.en_US
dc.identifier.citationKreis IV, Zhang L, Moritz S, Pfuhl G. Spared performance but increased uncertainty in schizophrenia: Evidence from a probabilistic decision-making task. Schizophrenia Research. 2021en_US
dc.identifier.cristinIDFRIDAID 1924373
dc.identifier.doi10.1016/j.schres.2021.06.038
dc.identifier.issn0920-9964
dc.identifier.issn1573-2509
dc.identifier.urihttps://hdl.handle.net/10037/23182
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalSchizophrenia Research
dc.relation.projectIDNorges forskningsråd: 262338en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/FRIMEDBIO/262338/Norway/Too precise or too imprecise: which parameter is gone awry in autism and psychosis//en_US
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0920996421002462
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Social science: 200::Psychology: 260en_US
dc.subjectVDP::Samfunnsvitenskap: 200::Psykologi: 260en_US
dc.titleSpared performance but increased uncertainty in schizophrenia: Evidence from a probabilistic decision-making tasken_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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