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dc.contributor.authorGillman, Aaron Nicholas
dc.contributor.authorMahmutovic, Anel
dc.contributor.authorAbel zur Wiesch, Pia
dc.contributor.authorAbel, Sören
dc.date.accessioned2022-01-24T09:05:53Z
dc.date.available2022-01-24T09:05:53Z
dc.date.issued2021-12-07
dc.description.abstractDuring infection, the rates of pathogen replication, death, and migration affect disease progression, dissemination, transmission, and resistance evolution. Here, we follow the population dynamics of Vibrio cholerae in a mouse model by labeling individual bacteria with one of >500 unique, fitness-neutral genomic tags. Using the changes in tag frequencies and CFU numbers, we inform a mathematical model that describes the within-host spatiotemporal bacterial dynamics. This allows us to disentangle growth, death, forward, and retrograde migration rates continuously during infection. Our model has robust predictive power across various experimental setups. The population dynamics of V. cholerae shows substantial spatiotemporal heterogeneity in replication, death, and migration. Importantly, we find that the niche available to V. cholerae in the host increases with inoculum size, suggesting cooperative effects during infection. Therefore, it is not enough to consider just the likelihood of exposure (50% infectious dose) but rather the magnitude of exposure to predict outbreaks.en_US
dc.identifier.citationGillman AN, Mahmutovic A, Abel zur Wiesch P, Abel S. The Infectious Dose Shapes Vibrio Cholerae Within-Host Dynamics. mSystems. 2021;6(6)en_US
dc.identifier.cristinIDFRIDAID 1971841
dc.identifier.doi10.1128/mSystems.00659-21
dc.identifier.issn2379-5077
dc.identifier.urihttps://hdl.handle.net/10037/23766
dc.language.isoengen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.relation.journalmSystems
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/FRIMEDBIO/262686/Norway/Predicting optimal antibiotic treatment regimens//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.titleThe Infectious Dose Shapes Vibrio Cholerae Within-Host Dynamicsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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