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MyD88 interacts with interferon regulatory factor (IRF) 3 and IRF7 in Atlantic salmon (Salmo salar): transgenic SsMyD88 modulates the IRF-induced type I interferon response and accumulates in aggresomes

dc.contributor.authorIliev, Dimitar Borisov
dc.contributor.authorSobhkhez, Mehrdad
dc.contributor.authorFremmerlid, Kjersti Kongsgården
dc.contributor.authorJørgensen, Jorunn B
dc.date.accessioned2022-09-14T11:06:23Z
dc.date.available2022-09-14T11:06:23Z
dc.date.issued2011-10-11
dc.description.abstractBackground: MyD88 directly interacts and affects IRF activation in mammals, but no information has been available about lower vertebrates.<p> <p>Results: Transgenic MyD88 interacts with IRF3 and IRF7A/B and modulates the IRF-induced IFN response and accumulates in aggresomes in Atlantic salmon. <p>Conclusion: MyD88 is involved in the regulation of the IRF-induced IFN response in Atlantic salmon. Significance: The results shed light on the evolution of the innate immune response in vertebrates.en_US
dc.identifier.citationIliev DB, Sobhkhez M, Fremmerlid KK, Jørgensen JB. MyD88 interacts with interferon regulatory factor (IRF) 3 and IRF7 in Atlantic salmon (Salmo salar): transgenic SsMyD88 modulates the IRF-induced type I interferon response and accumulates in aggresomes. Journal of Biological Chemistry. 2011;286(49):42715-42724en_US
dc.identifier.cristinIDFRIDAID 898485
dc.identifier.doi10.1074/jbc.M111.293969
dc.identifier.issn0021-9258
dc.identifier.issn1083-351X
dc.identifier.urihttps://hdl.handle.net/10037/26792
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalJournal of Biological Chemistry
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2011 American Society for Biochemistry and Molecular Biologyen_US
dc.titleMyD88 interacts with interferon regulatory factor (IRF) 3 and IRF7 in Atlantic salmon (Salmo salar): transgenic SsMyD88 modulates the IRF-induced type I interferon response and accumulates in aggresomesen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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