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dc.contributor.authorMäklin, Tommi
dc.contributor.authorThorpe, Harry Arthur Frank Wright
dc.contributor.authorPöntinen, Anna Kaarina
dc.contributor.authorGladstone, Rebecca Ashley
dc.contributor.authorShao, Yan
dc.contributor.authorPesonen, Maiju
dc.contributor.authorMcNally, Alan
dc.contributor.authorJohnsen, Pål Jarle
dc.contributor.authorSamuelsen, Ørjan
dc.contributor.authorLawley, Trevor D.
dc.contributor.authorHonkela, Antti
dc.contributor.authorCorander, Jukka
dc.date.accessioned2023-01-13T11:38:33Z
dc.date.available2023-01-13T11:38:33Z
dc.date.issued2022-12-01
dc.description.abstractOpportunistic bacterial pathogen species and their strains that colonise the human gut are generally understood to compete against both each other and the commensal species colonising this ecosystem. Currently we are lacking a population-wide quantification of strain-level colonisation dynamics and the relationship of colonisation potential to prevalence in disease, and how ecological factors might be modulating these. Here, using a combination of latest high-resolution metagenomics and strain-level genomic epidemiology methods we performed a characterisation of the competition and colonisation dynamics for a longitudinal cohort of neonatal gut microbiomes. We found strong inter- and intra-species competition dynamics in the gut colonisation process, but also a number of synergistic relationships among several species belonging to genus Klebsiella, which includes the prominent human pathogen Klebsiella pneumoniae. No evidence of preferential colonisation by hospitaladapted pathogen lineages in either vaginal or caesarean section birth groups was detected. Our analysis further enabled unbiased assessment of strain-level colonisation potential of extra-intestinal pathogenic Escherichia coli(ExPEC) in comparison with their propensity to cause bloodstream infections. Our study highlights the importance of systematic surveillance of bacterial gut pathogens, not only from disease but also from carriage state, to better inform therapies and preventive medicine in the future.en_US
dc.identifier.citationMäklin, Thorpe, Pöntinen, Gladstone, Shao, Pesonen, McNally, Johnsen, Samuelsen, Lawley, Honkela, Corander. Strong pathogen competition in neonatal gut colonisation. Nature Communications. 2022;13(1)en_US
dc.identifier.cristinIDFRIDAID 2094538
dc.identifier.doi10.1038/s41467-022-35178-5
dc.identifier.issn2041-1723
dc.identifier.urihttps://hdl.handle.net/10037/28208
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalNature Communications
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/EXCELLENT SCIENCE/742158/EU/Scalable inference algorithms for Bayesian evolutionary epidemiology/SCARABEE/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleStrong pathogen competition in neonatal gut colonisationen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)