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dc.contributor.authorSchneider, Yannik Karl Heinz
dc.contributor.authorLiaimer, Anton
dc.contributor.authorIsaksson, Johan Mattias
dc.contributor.authorWilhelmsen, Oda Sofie Bye
dc.contributor.authorAndersen, Jeanette Hammer
dc.contributor.authorØstnes Hansen, Kine
dc.contributor.authorHansen, Espen Holst
dc.date.accessioned2023-04-21T10:12:12Z
dc.date.available2023-04-21T10:12:12Z
dc.date.issued2023-04-20
dc.description.abstractThe suomilide and the banyasides are highly modified and functionalized non-ribosomal peptides produced by cyanobacteria of the order Nostocales. These compound classes share several substructures, including a complex azabicyclononane core, which was previously assumed to be derived from the amino acid tyrosine. In our study we were able to isolate and determine the structures of four suomilides, named suomilide B – E (1–4). The compounds differ from the previously isolated suomilide A by the functionalization of the glycosyl group. Compounds 1–4 were assayed for anti-proliferative, anti-biofilm and anti-bacterial activities, but no significant activity was detected. The sequenced genome of the producer organism Nostoc sp. KVJ20 enabled us to propose a biosynthetic gene cluster for suomilides. Our findings indicated that the azabicyclononane core of the suomilides is derived from prephenate and is most likely incorporated by a proline specific non-ribosomal peptide synthetase-unit.en_US
dc.identifier.citationSchneider, Liaimer, Isaksson, Wilhelmsen, Andersen, Østnes Hansen, Hansen. Four new suomilides isolated from the cyanobacterium Nostoc sp. KVJ20 and proposal of their biosynthetic origin. Frontiers in Microbiology. 2023en_US
dc.identifier.cristinIDFRIDAID 2142066
dc.identifier.doi10.3389/fmicb.2023.1130018
dc.identifier.issn1664-302X
dc.identifier.urihttps://hdl.handle.net/10037/29028
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers in Microbiology
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/721421/EU/Improving the flow in the pipeline of the next generation of marine biodiscovery scientists/MarPipe/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleFour new suomilides isolated from the cyanobacterium Nostoc sp. KVJ20 and proposal of their biosynthetic originen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)