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dc.contributor.authorAlonso, Sergio Arredondo
dc.contributor.authorBlundell-Hunter, George
dc.contributor.authorFu, Zuyi
dc.contributor.authorGladstone, Rebecca Ashley
dc.contributor.authorFillol-Salom, Alfred
dc.contributor.authorLoraine, Jessica
dc.contributor.authorCloutman-Green, Elaine
dc.contributor.authorJohnsen, Pål Jarle
dc.contributor.authorSamuelsen, Ørjan
dc.contributor.authorPöntinen, Anna Kaarina
dc.contributor.authorCleon, Francois Pierre Alexandre
dc.contributor.authorChavez-Bueno, Susana
dc.contributor.authorDe la Cruz, Miguel A.
dc.contributor.authorAres, Miguel A.
dc.contributor.authorVongsouvath, Manivanh
dc.contributor.authorChmielarczyk, Agnieszka
dc.contributor.authorHorner, Carolyne
dc.contributor.authorKlein, Nigel
dc.contributor.authorMcNally, Alan
dc.contributor.authorReis, Joice N.
dc.contributor.authorPenadés, José R.
dc.contributor.authorThomson, Nicholas R.
dc.contributor.authorCorander, Jukka
dc.contributor.authorTaylor, Peter W.
dc.contributor.authorMcCarthy, Alex J.
dc.date.accessioned2023-08-14T12:59:55Z
dc.date.available2023-08-14T12:59:55Z
dc.date.issued2023-06-15
dc.description.abstractEscherichia coli is a leading cause of invasive bacterial infections in humans. Capsule polysaccharide has an important role in bacterial pathogenesis, and the K1 capsule has been firmly established as one of the most potent capsule types in E. coli through its association with severe infections. However, little is known about its distribution, evolution and functions across the E. coli phylogeny, which is fundamental to elucidating its role in the expansion of successful lineages. Using systematic surveys of invasive E. coli isolates, we show that the K1-cps locus is present in a quarter of bloodstream infection isolates and has emerged in at least four different extraintestinal pathogenic E. coli (ExPEC) phylogroups independently in the last 500 years. Phenotypic assessment demonstrates that K1 capsule synthesis enhances E. coli survival in human serum independent of genetic background, and that therapeutic targeting of the K1 capsule re-sensitizes E. coli from distinct genetic backgrounds to human serum. Our study highlights that assessing the evolutionary and functional properties of bacterial virulence factors at population levels is important to better monitor and predict the emergence of virulent clones, and to also inform therapies and preventive medicine to effectively control bacterial infections whilst significantly lowering antibiotic usage.en_US
dc.identifier.citationAlonso, Blundell-Hunter, Fu, Gladstone, Fillol-Salom, Loraine, Cloutman-Green, Johnsen, Samuelsen, Pöntinen, Cleon, Chavez-Bueno, De la Cruz, Ares, Vongsouvath, Chmielarczyk, Horner, Klein, McNally, Reis, Penadés, Thomson, Corander, Taylor, McCarthy. Evolutionary and functional history of the Escherichia coli K1 capsule. Nature Communications. 2023;14(1)en_US
dc.identifier.cristinIDFRIDAID 2159411
dc.identifier.doi10.1038/s41467-023-39052-w
dc.identifier.issn2041-1723
dc.identifier.urihttps://hdl.handle.net/10037/29911
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalNature Communications
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleEvolutionary and functional history of the Escherichia coli K1 capsuleen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)