Show simple item record

dc.contributor.authorKværner, Ane Sørlie
dc.contributor.authorAndersen, Astrid Riseth
dc.contributor.authorHenriksen, Hege Berg
dc.contributor.authorKnudsen, Markus Dines
dc.contributor.authorJohansen, Anne Marte Wetting
dc.contributor.authorHjartåker, Anette
dc.contributor.authorBøhn, Siv Kjølsrud
dc.contributor.authorPaur, Ingvild
dc.contributor.authorWiedswang, Gro
dc.contributor.authorSmeland, Sigbjørn
dc.contributor.authorRounge, Trine Ballestad
dc.contributor.authorBlomhoff, Rune
dc.contributor.authorBerstad, Paula
dc.date.accessioned2023-08-15T08:58:20Z
dc.date.available2023-08-15T08:58:20Z
dc.date.issued2023-05-22
dc.description.abstractBackground: While adherence to cancer prevention recommendations is linked to lower risk of colorectal cancer (CRC), few have studied associations across the entire spectrum of colorectal carcinogenesis. Here, we studied the relationship of the standardized 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Score for cancer prevention recommendations with detection of colorectal lesions in a screening setting. As a secondary objective, we examined to what extent the recommendations were being followed in an external cohort of CRC patients. Methods: Adherence to the seven-point 2018 WCRF/AICR Score was measured in screening participants receiving a positive fecal immunochemical test and in CRC patients participating in an intervention study. Dietary intake, body fatness and physical activity were assessed using self-administered questionnaires. Multinomial logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for screen-detected lesions. Results: Of 1486 screening participants, 548 were free from adenomas, 524 had non-advanced adenomas, 349 had advanced lesions and 65 had CRC. Adherence to the 2018 WCRF/AICR Score was inversely associated with advanced lesions; OR 0.82 (95% CI 0.71, 0.94) per score point, but not with CRC. Of the seven individual components included in the score, alcohol, and BMI seemed to be the most influential. Of the 430 CRC patients included in the external cohort, the greatest potential for lifestyle improvement was seen for the recommendations concerning alcohol and red and processed meat, where 10% and 2% fully adhered, respectively. Conclusions: Adherence to the 2018 WCRF/AICR Score was associated with lower probability of screen-detected advanced precancerous lesions, but not CRC. Although some components of the score seemed to be more influential than others (i.e., alcohol and BMI), taking a holistic approach to cancer prevention is likely the best way to prevent the occurrence of precancerous colorectal lesions.en_US
dc.identifier.citationKværner, Andersen, Henriksen, Knudsen, Johansen, Hjartåker, Bøhn, Paur, Wiedswang, Smeland, Rounge, Blomhoff, Berstad. Associations of the 2018 World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR) cancer prevention recommendations with stages of colorectal carcinogenesis. Cancer Medicine. 2023en_US
dc.identifier.cristinIDFRIDAID 2153479
dc.identifier.doi10.1002/cam4.6119
dc.identifier.issn2045-7634
dc.identifier.urihttps://hdl.handle.net/10037/29943
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalCancer Medicine
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.subjectVDP::Medisinske fag: 700::Helsefag: 800::Forebyggende medisin: 804en_US
dc.subjectVDP::Midical sciences: 700::Health sciences: 800::Preventive medicine: 804en_US
dc.subjectKreft i tykktarm og endetarm / Colorectal canceren_US
dc.titleAssociations of the 2018 World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR) cancer prevention recommendations with stages of colorectal carcinogenesisen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record

Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)