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dc.contributor.authorTveiten, Helge
dc.contributor.authorAndersen, Øivind
dc.contributor.authorSwain, Jaya Kumari
dc.contributor.authorJohnsen, Hanne
dc.contributor.authorMommens, Maren
dc.contributor.authorSlanchev, Krasimir
dc.date.accessioned2023-08-31T08:11:21Z
dc.date.available2023-08-31T08:11:21Z
dc.date.issued2023
dc.description.abstractCultivation of sterile-only fish in aquaculture offers multiple benefits of environmental, economical, and social value. A reliable method for efficient sterilization without affecting fish welfare and performance traits would have significant impact on fish production practices. Here, we demonstrate sterilization of Atlantic salmon embryos by targeting the dead end gene with antisense oligonucleotides. Successful gene knock down and sterilization was achieved only when using Gapmer oligonucleotides and not with morpholino oligos. Germ cell-depleted embryos developed into morphologically normal male and female salmon with rudimentary gonads devoid of gametes.en_US
dc.identifier.citationTveiten H, Andersen Ø, Swain K, Johnsen H, Mommens M, Slanchev K. Production of sterile Atlantic salmon by germ cell ablation with antisense oligonucleotides. bioRxiv. 2023en_US
dc.identifier.cristinIDFRIDAID 2170892
dc.identifier.doi10.1101/2023.04.14.536849
dc.identifier.issn2692-8205
dc.identifier.urihttps://hdl.handle.net/10037/30570
dc.language.isoengen_US
dc.relation.journalbioRxiv
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleProduction of sterile Atlantic salmon by germ cell ablation with antisense oligonucleotidesen_US
dc.type.versionsubmittedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)