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dc.contributor.authorLouro, Javier
dc.contributor.authorRomán, Marta
dc.contributor.authorMoshina, Nataliia
dc.contributor.authorOlstad, Camilla F.
dc.contributor.authorLarsen, Marthe
dc.contributor.authorSagstad, Silje
dc.contributor.authorCastells, Xavier
dc.contributor.authorHofvind, Solveig Sand-Hanssen
dc.date.accessioned2023-11-14T14:33:03Z
dc.date.available2023-11-14T14:33:03Z
dc.date.issued2023-09-12
dc.description.abstractBackground: We aimed to develop and validate a model predicting breast cancer risk for women targeted by breast cancer screening. Method: This retrospective cohort study included 57,411 women screened at least once in BreastScreen Norway during the period from 2007 to 2019. The prediction model included information about age, mammographic density, family history of breast cancer, body mass index, age at menarche, alcohol consumption, exercise, pregnancy, hormone replacement therapy, and benign breast disease. We calculated a 4-year absolute breast cancer risk estimates for women and in risk groups by quartiles. The Bootstrap resampling method was used for internal validation of the model (E/O ratio). The area under the curve (AUC) was estimated with a 95% confidence interval (CI). Results: The 4-year predicted risk of breast cancer ranged from 0.22–7.33%, while 95% of the population had a risk of 0.55–2.31%. The thresholds for the quartiles of the risk groups, with 25% of the population in each group, were 0.82%, 1.10%, and 1.47%. Overall, the model slightly overestimated the risk with an E/O ratio of 1.10 (95% CI: 1.09–1.11) and the AUC was 62.6% (95% CI: 60.5–65.0%). Conclusions: This 4-year risk prediction model showed differences in the risk of breast cancer, supporting personalized screening for breast cancer in women aged 50–69 years.en_US
dc.identifier.citationLouro, Román, Moshina, Olstad, Larsen, Sagstad, Castells, Hofvind. Personalized Breast Cancer Screening: A Risk Prediction Model Based on Women Attending BreastScreen Norway. Cancers. 2023;15(18)en_US
dc.identifier.cristinIDFRIDAID 2188180
dc.identifier.doi10.3390/cancers15184517
dc.identifier.issn2072-6694
dc.identifier.urihttps://hdl.handle.net/10037/31785
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalCancers
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titlePersonalized Breast Cancer Screening: A Risk Prediction Model Based on Women Attending BreastScreen Norwayen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)