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dc.contributor.authorSagelv, Edvard Hamnvik
dc.contributor.authorHopstock, Laila Arnesdatter
dc.contributor.authorMorseth, Bente
dc.contributor.authorHansen, Bjørge Hermann
dc.contributor.authorSteene-Johannessen, Jostein
dc.contributor.authorJohansson, Jonas Lars
dc.contributor.authorNordström, Anna Hava
dc.contributor.authorSaint-Maurice, Pedro F
dc.contributor.authorLøvsletten, Ola
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorEkelund, Ulf
dc.contributor.authorTarp, Jakob
dc.date.accessioned2023-12-20T10:23:50Z
dc.date.available2023-12-20T10:23:50Z
dc.date.issued2023-10-24
dc.description.abstractObjectives - To examine whether moderate-to-vigorous physical activity (MVPA) modifies the association between sedentary time and mortality and vice versa, and estimate the joint associations of MVPA and sedentary time on mortality risk.<p> <p>Methods - This study involved individual participant data analysis of four prospective cohort studies (Norway, Sweden, USA, baseline: 2003–2016, 11 989 participants ≥50 years, 50.5% women) with hip-accelerometry-measured physical activity and sedentary time. Associations were examined using restricted cubic splines and fractional polynomials in Cox regressions adjusted for sex, education, body mass index, smoking, alcohol, study cohort, cardiovascular disease, cancer, and/or diabetes, accelerometry wear time and age.<p> <p>Results - 6.7% (n=805) died during follow-up (median 5.2 years, IQR 4.2 years). More than 12 daily sedentary hours (reference 8 hours) was associated with mortality risk only among those accumulating <22 min of MVPA per day (HR 1.38, 95% CI 1.10 to 1.74). Higher MVPA levels were associated with lower mortality risk irrespective of sedentary time, for example, HR for 10 versus 0 daily min of MVPA was 0.85 (95% CI 0.74 to 0.96) in those accumulating <10.5 daily sedentary hours and 0.65 (95% CI 0.53 to 0.79) in those accumulating ≥10.5 daily sedentary hours. Joint association analyses confirmed that higher MVPA was superior to lower sedentary time in lowering mortality risk, for example, 10 versus 0 daily min of MVPA was associated with 28–55% lower mortality risk across the sedentary time spectrum (lowest risk, 10 daily sedentary hours: HR 0.45, 95% CI 0.31 to 0.65).<p> <p>Conclusions - Sedentary time was associated with higher mortality risk but only in individuals accumulating less than 22 min of MVPA per day. Higher MVPA levels were associated with lower mortality risk irrespective of the amount of sedentary time.en_US
dc.identifier.citationSagelv EH, Hopstock LA, Morseth B, Hansen BH, Steene-Johannessen J, Johansson J, Nordström AH, Saint-Maurice PF, Løvsletten O, Wilsgaard T, Ekelund U, Tarp J. Device-measured physical activity, sedentary time, and risk of all-cause mortality: an individual participant data analysis of four prospective cohort studies. British Journal of Sports Medicine. 2023;57(22):1457-1463
dc.identifier.cristinIDFRIDAID 2189004
dc.identifier.doi10.1136/bjsports-2022-106568
dc.identifier.issn0306-3674
dc.identifier.issn1473-0480
dc.identifier.urihttps://hdl.handle.net/10037/32172
dc.language.isoengen_US
dc.publisherBMJ Publishing Groupen_US
dc.relation.journalBritish Journal of Sports Medicine
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.titleDevice-measured physical activity, sedentary time, and risk of all-cause mortality: an individual participant data analysis of four prospective cohort studiesen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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