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dc.contributor.authorLarsen, Bjarke Strøm
dc.contributor.authorKissi, Eric Ofosu
dc.contributor.authorParreiras Nogueira, Liebert
dc.contributor.authorGenina, Natalja
dc.contributor.authorTho, Ingunn
dc.date.accessioned2024-01-12T20:56:11Z
dc.date.available2024-01-12T20:56:11Z
dc.date.issued2023-11-02
dc.description.abstract<p>This study investigates the influence of drug load and polymer molecular weight on the structure of tablets three-dimensionally (3D) printed from the binary mixture of prednisolone and hydroxypropyl methylcellulose (HPMC). Three different HPMC grades, (AFFINISOLTM HPMC HME 15LV, 90 Da (HPMC 15LV); 100LV, 180 Da (HPMC 100LV); 4M, 500 Da (HPMC 4M)), which are suitable for hot-melt extrusion (HME), were used in this study. HME was used to fabricate feedstock material, i.e., filaments, at the lowest possible extrusion temperature. Filaments of the three HPMC grades were prepared to contain 2.5, 5, 10 and 20 % (w/w) prednisolone. The thermal degradation of the filaments was studied with thermogravimetric analysis, while solid-state properties of the drug-loaded filaments were assessed with the use of X-ray powder diffraction. Prednisolone in the freshly extruded filaments was determined to be amorphous for drug loads up to 10%. It remained physically stable for at least 6 months of storage, except for the filament containing 10% drug with HPMC 15LV, where recrystallization of prednisolone was detected. <p>Fused deposition modeling was utilized to print honeycomb-shaped tablets from the HME filaments of HPMC 15LV and 100LV. The structural characteristics of the tablets were evaluated using X-ray microcomputed tomography, specifically porosity and size of structural elements were investigated. The tablets printed from HPMC 15LV possessed in general lower total porosity and pores of smaller size than tablets printed from the HPMC 100LV. The studied drug loads were shown to have minor effect on the total porosity of the tablets, though the lower the drug load was, the higher the variance of porosity along the height of the tablet was observed. It was found that tablets printed with HPMC 15LV showed higher structural similarity with the virtually designed model than tablets printed from HPMC 100LV. These findings highlight the relevance of the drug load and polymer molecular weight on the microstructure and structural properties of 3D printed tablets.en_US
dc.identifier.citationLarsen, Kissi, Parreiras Nogueira, Genina, Tho. Impact of Drug Load and Polymer Molecular Weight on the 3D Microstructure of Printed Tablets. Journal of Pharmaceutical Sciences. 2023en_US
dc.identifier.cristinIDFRIDAID 2213612
dc.identifier.doi10.1016/j.ejps.2023.106619
dc.identifier.issn0022-3549
dc.identifier.issn1520-6017
dc.identifier.urihttps://hdl.handle.net/10037/32475
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalJournal of Pharmaceutical Sciences
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleImpact of Drug Load and Polymer Molecular Weight on the 3D Microstructure of Printed Tabletsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)