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dc.contributor.authorLi, Zhi-Qiang
dc.contributor.authorLiu, Xin-Xin
dc.contributor.authorWang, Xue-Feng
dc.contributor.authorShen, Chen
dc.contributor.authorCao, Feng
dc.contributor.authorGuan, Xin-Miao
dc.contributor.authorZhang, Ying
dc.contributor.authorLiu, Jianping
dc.date.accessioned2024-08-22T08:24:26Z
dc.date.available2024-08-22T08:24:26Z
dc.date.issued2024-07-24
dc.description.abstractBackground: Hypoalbuminemia and cognitive impairment (CI) each independently increase the mortality risk in older adults. However, these two geriatric syndromes can occur simultaneously. In community-dwelling older adults, is the combination of hypoalbuminemia and CI linked to a higher mortality risk than either condition alone?<p> <p>Objective: We aimed to investigate the association between plasma albumin, cognitive function, and their synergistic effect on mortality in Chinese community-dwelling older adults. Methods: Data from the Chinese Longitudinal Healthy Longevity Survey (2012) included 1,858 participants aged ≥65. Baseline assessments comprised albumin levels and cognitive status. All-cause mortality was confirmed through 2014– 2018 surveys. Cox proportional hazards models assessed associations, and restricted cubic splines explored albumin-mortality relationship. <p>Results: During a median follow-up of 48.85  months, 921 deaths. Albumin≥35  g/L vs  <  35g/L [HR: 1.33 (95%CI, 1.10, 1.62)] and CI vs normal cognition [HR: 1.69 (95%CI, 1.43, 1.99)] independently predicted mortality. A dose–response relationship with mortality was observed for albumin quartiles (p  <  0.001). Each SD increase in MMSE or albumin correlated with 22% and 15% lower mortality risk, respectively. Combined hypoproteinemia and CI increased the mortality risk by 155%, with a notably higher risk in males, those aged <85  years, and individuals living in rural areas. Interaction effects of albumin and CI on mortality were observed (p  <  0.001). In the single CI group, older adults had a 61% increased risk of mortality in the hypoproteinaemia group compared with the albuminnormal group. Restricted cubic spline revealed a reverse J-shaped association, particularly for participants without CI. For individuals with CI, albumin levels were inversely associated with mortality risk. <p>Conclusion: Hypoproteinemia and CI, individually and combined, increased all-cause mortality risk in Chinese older adults, with stronger effects observed in males, younger older adults, and those living in rural areas. These findings emphasize the importance of targeted adjustments and early nutrition programs in health prevention and clinical care for older adults.en_US
dc.identifier.citationLi, Liu, Wang, Shen, Cao, Guan, Zhang, Liu. Synergistic impact of plasma albumin and cognitive function on all-cause mortality in Chinese older adults: a prospective cohort study. Frontiers in Nutrition. 2024;11en_US
dc.identifier.cristinIDFRIDAID 2287362
dc.identifier.doi10.3389/fnut.2024.1410196
dc.identifier.issn2296-861X
dc.identifier.urihttps://hdl.handle.net/10037/34351
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers in Nutrition
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleSynergistic impact of plasma albumin and cognitive function on all-cause mortality in Chinese older adults: a prospective cohort studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
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