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dc.contributor.authorBrobak, Karl Marius
dc.contributor.authorHalvorsen, Lene Vernås
dc.contributor.authorAass, Hans Christian
dc.contributor.authorSøraas, Camilla Lund
dc.contributor.authorAune, Arleen
dc.contributor.authorOlsen, Erik
dc.contributor.authorBergland, Ola Undrum
dc.contributor.authorRognstad, Stine
dc.contributor.authorBlom, Kjersti Benedicte
dc.contributor.authorBirkeland, Jon Arne
dc.contributor.authorHøieggen, Aud
dc.contributor.authorLarstorp, Anne Cecilie Kjeldsen
dc.contributor.authorSolbu, Marit Dahl
dc.date.accessioned2024-08-23T10:31:05Z
dc.date.available2024-08-23T10:31:05Z
dc.date.issued2024-04-12
dc.description.abstractIntroduction: estimated glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (acR)are insensitive biomarkers for early detection of hypertension-mediated organ damage (hMOD).in this nationwide cross-sectional study, we assessed potential biomarkers for early hMOD inhealthy persons and patients with hypertension. We hypothesised that plasma levels of biomarkers:(1) are different between healthy controls and patients with hypertension, (2): can classify patientswith hypertension according to the degree of hypertension severity.<p><p>Design and methods: Patients with hypertension prescribed ≥2 antihypertensive agents wereselected from a multicentre study. healthy controls were selected from an ongoing study of livingkidney donor candidates. Uncontrolled hypertension was defined as systolic daytime ambulatoryblood pressure ≥135 mmhg. Kidney hMOD was defined by acR > 3.0 mg/mmol or eGFR < 60 ml/min/1.73 m2. Patients with hypertension were categorised into three groups: (1) controlledhypertension; (2) uncontrolled hypertension without kidney hMOD; (3) uncontrolled hypertensionwith kidney hMOD. Fifteen biomarkers were analysed using a luminex bead-based immunoassay,and nine fell within the specified analytical range.<p>Results: Plasma levels of interleukin 1 receptor antagonist (il-1Ra), neutrophil gelatinase-associatedlipocalin (NGal) and uromodulin were significantly different between healthy controls (n = 39)and patients with hypertension (n = 176). in regression models, with controlled hypertension(n = 55) as the reference category, none of the biomarkers were associated with uncontrolledhypertension without (n = 59) and with (n = 62) kidney hMOD. in models adjusted forcardiovascular risk factors and eGFR, osteopontin (OPN) was associated with uncontrolledhypertension without kidney hMOD (odds ratio (OR) 1.77 (1.05–2.98), p = 0.03), and regulatedupon activation normal t-cell expressed and secreted (RaNtes) with uncontrolled hypertensionwith kidney hMOD (OR 0.57 (0.34–0.95), p = 0.03).<p>Conclusions: None of the biomarkers could differentiate our hypertension groups whenestablished risk factors were considered. Plasma OPN may identify patients with uncontrolledhypertension at risk for kidney hMOD.en_US
dc.identifier.citationBrobak, Halvorsen, Aass, Søraas, Aune, Olsen, Bergland, Rognstad, Blom, Birkeland, Høieggen, Larstorp, Solbu. Novel biomarkers in patients with uncontrolled hypertension with and without kidney damage. Blood Pressure. 2024;33(1)en_US
dc.identifier.cristinIDFRIDAID 2267880
dc.identifier.doi10.1080/08037051.2024.2323980
dc.identifier.issn0803-7051
dc.identifier.issn1651-1999
dc.identifier.urihttps://hdl.handle.net/10037/34374
dc.language.isoengen_US
dc.publisherTaylor & Francisen_US
dc.relation.journalBlood Pressure
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0en_US
dc.rightsAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)en_US
dc.titleNovel biomarkers in patients with uncontrolled hypertension with and without kidney damageen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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