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dc.contributor.authorEriksson, Cecilia Magdalena
dc.contributor.authorKirsebom, Bjørn-Eivind Seljelid
dc.contributor.authorEspenes, Ragna
dc.contributor.authorSiafarikas, Nikias Ioannis
dc.contributor.authorWaterloo, Knut
dc.contributor.authorRongve, Arvid
dc.contributor.authorSelnes, Per
dc.contributor.authorAarsland, Dag
dc.contributor.authorFladby, Tormod
dc.contributor.authorHessen, Erik
dc.date.accessioned2024-09-24T07:50:10Z
dc.date.available2024-09-24T07:50:10Z
dc.date.issued2024-05-10
dc.description.abstractIntroduction: Depressive symptoms are associated with Alzheimer’s disease (AD), but their neurobiological and neuropsychological correlates remain poorly understood. We investigate if depressive symptoms are associated with amyloid (Aβ) pathology and cognition in predementia AD.<p><p> Methods: We included subjective cognitive decline (SCD, n = 160) and mild cognitive impairment (MCI, n = 192) from the dementia disease initiation cohort. Depressive symptoms were assessed using the Geriatric Depression Scale (GDS-15). Aβ pathology was determined using cerebrospinal fluid (CSF) Aβ42/40 ratio. Associations between depressive symptoms and cognition were assessed with logistic regression. <p>Results: Only the Aβ negative MCI group (MCI-Aβ−) was associated with depressive symptoms (odds ratio [OR] = 2.65, p = 0.005). Depressive symptoms were associated with worse memory in MCI-Aβ− (OR = 0.94, p = 0.039), but with better performance in MCI-Aβ+ (OR = 1.103, p = 0.001). <p>Conclusion: Our results suggest that depressive symptoms in MCI are neither associated with Aβ pathology, nor AD-associated memory impairment. However, memory impairment in non-AD MCI may relate to depressive symptoms.en_US
dc.identifier.citationEriksson, Kirsebom, Espenes, Siafarikas, Waterloo, Rongve, Selnes, Aarsland, Fladby, Hessen. Depressive Symptoms Are Not Associated with Predementia Cerebrospinal Fluid Amyloid Pathology. Dementia and Geriatric Cognitive Disorders Extra. 2024;14(1):40-48en_US
dc.identifier.cristinIDFRIDAID 2282531
dc.identifier.doi10.1159/000539284
dc.identifier.issn1664-5464
dc.identifier.urihttps://hdl.handle.net/10037/34839
dc.language.isoengen_US
dc.publisherKargeren_US
dc.relation.journalDementia and Geriatric Cognitive Disorders Extra
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0en_US
dc.rightsAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)en_US
dc.titleDepressive Symptoms Are Not Associated with Predementia Cerebrospinal Fluid Amyloid Pathologyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)