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dc.contributor.authorAune, Arleen
dc.contributor.authorOhldieck, Annabel Eide
dc.contributor.authorHalvorsen, Lene Vernås
dc.contributor.authorBrobak, Karl Marius
dc.contributor.authorOlsen, Erik
dc.contributor.authorRognstad, Stine
dc.contributor.authorLarstorp, Anne Cecilie Kjeldsen
dc.contributor.authorSøraas, Camilla Lund
dc.contributor.authorRossebø, Anne Bjørhovde
dc.contributor.authorRösner, Assami
dc.contributor.authorGrytaas, Marianne Aardal
dc.contributor.authorGerdts, Eva
dc.date.accessioned2024-10-02T10:08:14Z
dc.date.available2024-10-02T10:08:14Z
dc.date.issued2024-03-26
dc.description.abstractIntroduction Cardiac organ damage like left ventricular (LV) hypertrophy and left atrial (LA) enlargement is more prevalent in women than men with hypertension, but the mechanisms underlying this gender difference remain unclear.<p> <p>Methods We tested the association of drug nonadherence with the presence of LV hypertrophy and LA enlargement by echocardiography in 186 women and 337 men with uncontrolled hypertension defined as daytime systolic blood pressure (BP) ≥ 135mmHg despite the prescription of at least two antihypertensive drugs. Drug adherence was assessed by measurements of serum drug concentrations interpreted by an experienced pharmacologist. Aldosterone-renin-ratio (ARR) was measured on actual medication. <p>Results Women had a higher prevalence of LV hypertrophy (46% vs. 33%) and LA enlargement (79% vs 65%, both p < 0.05) than men, while drug nonadherence (8% vs. 9%, p > 0.514) did not differ. Women were older and had lower serum renin concentration and higher ARR than men, while 24-h systolic BP (141 ± 9 mmHg vs. 142 ± 9 mmHg), and the prevalences of obesity (43% vs. 50%) did not differ (all p > 0.10). In multivariable analyses, female gender was independently associated with a two-fold increased risk of LV hypertrophy (OR 2.01[95% CI 1.30–3.10], p = 0.002) and LA enlargement (OR 1.90 [95% CI 1.17–3.10], p = 0.010), while no association with drug nonadherence was found. Higher ARR was independently associated with LV hypertrophy in men only (OR 2.12 [95% CI 1.12–4.00] p = 0.02). <p>Conclusions Among patients with uncontrolled hypertension, the higher prevalence of LV hypertrophy and LA enlargement in women was not explained by differences in drug nonadherence.en_US
dc.identifier.citationAune, Ohldieck, Halvorsen, Brobak, Olsen, Rognstad, Larstorp, Søraas, Rossebø, Rösner, Grytaas, Gerdts. Gender Differences in Cardiac Organ Damage in Arterial Hypertension: Assessing the Role of Drug Nonadherence. High Blood Pressure & Cardiovascular Prevention. 2024
dc.identifier.cristinIDFRIDAID 2263841
dc.identifier.doi10.1007/s40292-024-00632-6
dc.identifier.issn1120-9879
dc.identifier.issn1179-1985
dc.identifier.urihttps://hdl.handle.net/10037/34964
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalHigh Blood Pressure & Cardiovascular Prevention
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleGender Differences in Cardiac Organ Damage in Arterial Hypertension: Assessing the Role of Drug Nonadherenceen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)