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dc.contributor.authorAppenroth, Daniel
dc.contributor.authorCazarez Marquez, Fernando
dc.date.accessioned2024-10-03T09:56:51Z
dc.date.available2024-10-03T09:56:51Z
dc.date.issued2024-06-22
dc.description.abstractAnimals inhabiting temperate and high latitudes undergo drastic seasonal changes in energy storage, facilitated by changes in food intake and body mass. Those seasonal changes in the animal’s biology are not mere consequences of environmental energy availability but are anticipatory responses to the energetic requirements of the upcoming season and are actively timed by tracking the annual progression in photoperiod. In this review, we discuss how photoperiod is used to control energy balance seasonally and how this is distinct from energy homeostasis. Most notably, we suggest that photoperiodic control of food intake and body mass does not originate from the arcuate nucleus, as for homeostatic appetite control, but is rather to be found in hypothalamic tanycytes. Tanycytes are specialized ependymal cells lining the third ventricle, which can sense metabolites from the cerebrospinal fluid (e.g. glucose) and can control access of circulating signals to the brain. They are also essential in conveying time-of-year information by integrating photoperiod and altering hypothalamic thyroid metabolism, a feature that is conserved in seasonal vertebrates and connects to seasonal breeding and metabolism. We also discuss how homeostatic feedback signals are handled during times of rapid energetic transitions. Studies on leptin in seasonal mammals suggest a seasonal shift in central sensitivity and blood-brain transport, which might be facilitated by tanycytes. This article is part of the Special Issue on "Food intake and feeding states".en_US
dc.identifier.citationAppenroth, Cazarez Marquez. Seasonal food intake and energy balance: Neuronal and non-neuronal control mechanisms. Neuropharmacology. 2024;257en_US
dc.identifier.cristinIDFRIDAID 2281359
dc.identifier.doi10.1016/j.neuropharm.2024.110050
dc.identifier.issn0028-3908
dc.identifier.issn1873-7064
dc.identifier.urihttps://hdl.handle.net/10037/35012
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalNeuropharmacology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleSeasonal food intake and energy balance: Neuronal and non-neuronal control mechanismsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)