dc.contributor.author | Appenroth, Daniel | |
dc.contributor.author | Cazarez Marquez, Fernando | |
dc.date.accessioned | 2024-10-03T09:56:51Z | |
dc.date.available | 2024-10-03T09:56:51Z | |
dc.date.issued | 2024-06-22 | |
dc.description.abstract | Animals inhabiting temperate and high latitudes undergo drastic seasonal changes in energy storage, facilitated by changes in food intake and body mass. Those
seasonal changes in the animal’s biology are not mere consequences of environmental energy availability but are anticipatory responses to the energetic requirements
of the upcoming season and are actively timed by tracking the annual progression in photoperiod.
In this review, we discuss how photoperiod is used to control energy balance seasonally and how this is distinct from energy homeostasis. Most notably, we suggest
that photoperiodic control of food intake and body mass does not originate from the arcuate nucleus, as for homeostatic appetite control, but is rather to be found in
hypothalamic tanycytes. Tanycytes are specialized ependymal cells lining the third ventricle, which can sense metabolites from the cerebrospinal fluid (e.g. glucose)
and can control access of circulating signals to the brain. They are also essential in conveying time-of-year information by integrating photoperiod and altering
hypothalamic thyroid metabolism, a feature that is conserved in seasonal vertebrates and connects to seasonal breeding and metabolism.
We also discuss how homeostatic feedback signals are handled during times of rapid energetic transitions. Studies on leptin in seasonal mammals suggest a
seasonal shift in central sensitivity and blood-brain transport, which might be facilitated by tanycytes.
This article is part of the Special Issue on "Food intake and feeding states". | en_US |
dc.identifier.citation | Appenroth, Cazarez Marquez. Seasonal food intake and energy balance: Neuronal and non-neuronal control mechanisms. Neuropharmacology. 2024;257 | en_US |
dc.identifier.cristinID | FRIDAID 2281359 | |
dc.identifier.doi | 10.1016/j.neuropharm.2024.110050 | |
dc.identifier.issn | 0028-3908 | |
dc.identifier.issn | 1873-7064 | |
dc.identifier.uri | https://hdl.handle.net/10037/35012 | |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.journal | Neuropharmacology | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2024 The Author(s) | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | en_US |
dc.rights | Attribution 4.0 International (CC BY 4.0) | en_US |
dc.title | Seasonal food intake and energy balance: Neuronal and non-neuronal control mechanisms | en_US |
dc.type.version | publishedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |