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dc.contributor.authorHansen, Solrunn
dc.contributor.authorXu, Shanshan
dc.contributor.authorHuber, Sandra
dc.contributor.authorAlvarez, Marisa Viviana
dc.contributor.authorOdland, Jon Øyvind
dc.date.accessioned2024-10-03T12:19:12Z
dc.date.available2024-10-03T12:19:12Z
dc.date.issued2024-01-13
dc.description.abstractBackground: Per- and polyfluoroalkyl substances (PFAS) are a group of synthetic chemicals with potential adverse health effects. Information concerning PFAS concentrations in relation to pregnancy is scarce in South America and non-existent in Argentina. Aim: We aimed to investigate an extended maternal PFAS profile herein serum concentrations in a regional and global view, source appointment, and determinants in Argentinean women.<p> <p>Methods: A cross-sectional study with a sampling period from 2011 to 2012 included 689 women from Ushuaia and Salta in Argentina. Serum samples collected two days postpartum were analyzed by ultra-high pressure liquid chromatography coupled to electrospray negative ionisation tandem-quadrupole mass-spectrometry. Principal Component Analysis (PCA) following absolute principal component score-multiple linear regression (APCS-MLR) was used for PFAS source appointments. Determinants of PFAS were explored through a MLR approach. A review of previous studies within the same period was conducted to compare with present levels. <p>Results: Argentinean PFAS concentrations were the lowest worldwide, with PFOS (0.74 ng/mL) and PFOA (0.11 ng/mL) as the dominant substances. Detection frequencies largely aligned with the compared studies, indicating the worldwide PFAS distribution considering the restrictions. The PCA revealed region-specific loading patterns of two component groups of PFAS, a mixture of replaced and legacy substances in Ushuaia and long-chain in Salta. This might relate to a mix of non-diet and diet exposure in Ushuaia and diet in Salta. Region, age, lactation, parity, household members, migration, bottled water, and freshwater fish were among the determinants of various PFAS. <p>Conclusion: This is the first study to monitor human PFAS exposure in Argentina. Maternal PFAS concentrations were the lowest observed worldwide in the same period. Exposure contributions are suggested to be affected by restrictions and substitutions. Given the limited population-based studies and the emergence of PFAS, it is essential to conduct further monitoring of PFAS in Argentina and South America.en_US
dc.identifier.citationHansen, Xu, Huber, Alvarez, Odland. Profile of per- and polyfluoroalkyl substances, source appointment, and determinants in Argentinean postpartum women. Science of the Total Environment. 2024;915en_US
dc.identifier.cristinIDFRIDAID 2245872
dc.identifier.doi10.1016/j.scitotenv.2024.170096
dc.identifier.issn0048-9697
dc.identifier.issn1879-1026
dc.identifier.urihttps://hdl.handle.net/10037/35033
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalScience of the Total Environment
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleProfile of per- and polyfluoroalkyl substances, source appointment, and determinants in Argentinean postpartum womenen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)