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dc.contributor.authorMelum, Vebjørn Jacobsen
dc.contributor.authorSáenz de Miera, Cristina
dc.contributor.authorMarkussen, Fredrik Andreas Fasth
dc.contributor.authorCazarez Marquez, Fernando
dc.contributor.authorJaeger, Catherine
dc.contributor.authorSandve, Simen Rød
dc.contributor.authorSimonneaux, Valérie
dc.contributor.authorHazlerigg, David Grey
dc.contributor.authorWood, Shona Hiedi
dc.date.accessioned2024-10-08T12:27:54Z
dc.date.available2024-10-08T12:27:54Z
dc.date.issued2024-01-12
dc.description.abstractIn mammals, maternal photoperiodic programming (MPP) provides a means whereby juvenile development can be matched to forthcoming seasonal environmental conditions.<sup>1–4</sup> This phenomenon is driven by in utero effects of maternal melatonin<sup>5–7</sup> on the production of thyrotropin (TSH) in the fetal pars tuberalis (PT) and consequent TSH receptor-mediated effects on tanycytes lining the 3rd ventricle of the mediobasal hypothalamus (MBH).<sup>8–10</sup> Here we use LASER capture microdissection and transcriptomic profiling to show that TSHdependent MPP controls the attributes of the ependymal region of the MBH in juvenile animals. In Siberian hamster pups gestated and raised on a long photoperiod (LP) and thereby committed to a fast trajectory for growth and reproductive maturation, the ependymal region is enriched for tanycytes bearing sensory cilia and receptors implicated in metabolic sensing. Contrastingly, in pups gestated and raised on short photoperiod (SP) and therefore following an over-wintering developmental trajectory with delayed sexual maturation, the ependymal region has fewer sensory tanycytes. Post-weaning transfer of SP-gestated pups to an intermediate photoperiod (IP), which accelerates reproductive maturation, results in a pronounced shift toward a ciliated tanycytic profile and formation of tanycytic processes. We suggest that tanycytic plasticity constitutes a mechanism to tailor metabolic development for extended survival in variable overwintering environments.en_US
dc.identifier.citationMelum, Sáenz de Miera, Markussen, Cazarez Marquez, Jaeger, Sandve, Simonneaux, Hazlerigg, Wood. Hypothalamic tanycytes as mediators of maternally programmed seasonal plasticity. Current Biology. 2024;34(3):632-640.e6en_US
dc.identifier.cristinIDFRIDAID 2249060
dc.identifier.doi10.1016/j.cub.2023.12.042
dc.identifier.issn0960-9822
dc.identifier.issn1879-0445
dc.identifier.urihttps://hdl.handle.net/10037/35128
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalCurrent Biology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleHypothalamic tanycytes as mediators of maternally programmed seasonal plasticityen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)