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dc.contributor.authorMarkussen, Fredrik Andreas Fasth
dc.contributor.authorCázarez-Márquez, Fernando
dc.contributor.authorMelum, Vebjørn Jacobsen
dc.contributor.authorHazlerigg, David Grey
dc.contributor.authorWood, Shona Hiedi
dc.date.accessioned2024-10-09T08:49:30Z
dc.date.available2024-10-09T08:49:30Z
dc.date.issued2024-05-23
dc.description.abstractHibernation is an extreme state of seasonal energy conservation, reducing metabolic rate to as little as 1% of the active state. During the hibernation season, many species of hibernating mammals cycle repeatedly between the active (aroused) and hibernating (torpid) states (T–A cycling), using brown adipose tissue (BAT) to drive cyclical rewarming. The regulatory mechanisms controlling this process remain undefined but are presumed to involve thermoregulatory centres in the hypothalamus. Here, we used the golden hamster (Mesocricetus auratus), and high-resolution monitoring of BAT, core body temperature and ventilation rate, to sample at precisely defined phases of the T–A cycle. Using c-fos as a marker of cellular activity, we show that although the dorsomedial hypothalamus is active during torpor entry, neither it nor the pre-optic area shows any significant changes during the earliest stages of spontaneous arousal. Contrastingly, in three non-neuronal sites previously linked to control of metabolic physiology over seasonal and daily time scales – the choroid plexus, pars tuberalis and third ventricle tanycytes – peak c-fos expression is seen at arousal initiation. We suggest that through their sensitivity to factors in the blood or cerebrospinal fluid, these sites may mediate metabolic feedback-based initiation of the spontaneous arousal process.en_US
dc.identifier.citationMarkussen FAS, Cázarez-Márquez, Melum, Hazlerigg, Wood. c-fos induction in the choroid plexus, tanycytes and pars tuberalis is an early indicator of spontaneous arousal from torpor in a deep hibernator. Journal of Experimental Biology. 2024;227(10)en_US
dc.identifier.cristinIDFRIDAID 2280062
dc.identifier.doi10.1242/jeb.247224
dc.identifier.issn0022-0949
dc.identifier.issn1477-9145
dc.identifier.urihttps://hdl.handle.net/10037/35139
dc.language.isoengen_US
dc.publisherThe Company of Biologistsen_US
dc.relation.journalJournal of Experimental Biology
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/European Research Council /101086671/EU/Hibernation timing to reveal mechanisms of rheostasis/HiTime/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Company of Biologistsen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titlec-fos induction in the choroid plexus, tanycytes and pars tuberalis is an early indicator of spontaneous arousal from torpor in a deep hibernatoren_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)