Det helsevitenskapelige fakultet: Nye registreringer
Viser treff 1181-1200 av 10404
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Impact of microvessel patterns and immune status in NSCLC: a non-angiogenic vasculature is an independent negative prognostic factor in lung adenocarcinoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-26)Introduction: Non-small cell lung carcinomas (NSCLC) exhibit different microvessel patterns (MVPs). Basal (BA), diffuse (DA) and papillary (PA) patterns show signs of angiogenesis (new blood vessels), while an alveolar pattern indicates that tumors are co-opting existing normal vessels (non-angiogenic alveolar, NAA). NAA tumor growth is known to exist in NSCLC, but little is known about its prognostic ... -
Targeting NETs using dual-active DNase1 variants
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-23)Background: Neutrophil Extracellular Traps (NETs) are key mediators of immunothrombotic mechanisms and defective clearance of NETs from the circulation underlies an array of thrombotic, inflammatory, infectious, and autoimmune diseases. Efficient NET degradation depends on the combined activity of two distinct DNases, DNase1 and DNase1-like 3 (DNase1L3) that preferentially digest double-stranded DNA ... -
A healthy lifestyle index and cancer: Using a multifactor lifestyle exposure to estimate cancer incidence and survival among Norwegian women
(Doctoral thesis; Doktorgradsavhandling, 2023-08-17)<p><i>Background:</i> Cancer is the leading cause of death in Norway, and lifestyle behaviors are a major contributor to cancer risk. This thesis aimed to investigate the association between a healthy lifestyle index (HLI) and cancer incidence and survival among women in Norway. <p><i>Methods:</i> The study used data from the Norwegian Women and Cancer Study, a national prospective cohort of ... -
Microbiome Structure and Mucosal Morphology of Jejunum Appendix and Colon of Rats in Health and Dysbiosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-06)Gut microbiota contributes to human health. Plenty of studies demonstrate that antibiotics can disrupt gut ecosystem leading to dysbiosis. Little is known about the microbial variation of appendix and its up/downstream intestine after antibiotic treatment. This study aimed to investigate the microbiome and mucosal morphology of jejunum, appendix, and colon of rats in health and dysbiosis. A rodent ... -
Clinical Diagnostics of Bacterial Infections and Their Resistance to Antibiotics—Current State and Whole Genome Sequencing Implementation Perspectives
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-19)Antimicrobial resistance (AMR), defined as the ability of microorganisms to withstand antimicrobial treatment, is responsible for millions of deaths annually. The rapid spread of AMR across continents warrants systematic changes in healthcare routines and protocols. One of the fundamental issues with AMR spread is the lack of rapid diagnostic tools for pathogen identification and AMR detection. ... -
“My cousin said to me ...” Patients’ use of 3rd-party references to facilitate shared decision-making during naturally occurring primary care consultations.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-30)In this paper, we explore the ways in which patients invoke third parties to gain decision-making influence in clinical consultations. The patients’ role in decision-making processes is often overlooked, and this interactional practice has rarely been systematically studied. Through a contextual narrative exploration of 42 naturally occurring consultations between patients (aged 22–84) and general ... -
Study Protocol: The Arctic Childhood Study: a Study of Violence and Health in Indigenous Sámi and Non-Sámi Children and Youth in Arctic Norway—a Mixed Methods Cohort Study Design
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-04)Our current knowledge about the health status and developmental process and outcome of Indigenous Sámi children and youths in the high north (Northern Norway, 68 degrees latitude) is scarce. The present longitudinal study, labeled the Arctic Childhood Study, aims to fll major knowledge gaps related to this topic with a special focus on the incidence of violence, abuse, and neglect as well as ... -
Preoperative Inflammatory Markers in Liver Resection for Colorectal Liver Metastases: A National Registry-Based Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-04)Background Preoperative inflammatory markers were shown to be associated with prognosis following surgery for hepato-pancreato-biliary cancer. Yet little evidence exists about their role in patients with colorectal liver metastases (CRLM). This study aimed to examine the association between selected preoperative inflammatory markers and outcomes of liver resection for CRLM.<p> <p>Methods Data ... -
Quality of life, mentalization, and perception of challenging patient encounters in dentistry: A cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-07)Objective: This study investigated how exposure to challenging patient encounters influenced participants’ self-reported quality of life, and how participants’ mentalization capabilities affected the perceptions of challenging patients encounters among Norwegian dentists and dental students.<p> <p>Materials and Methods: Data was collected with an online questionnaire, and a total of 165 dentists (n ... -
Diet and lifestyle in relation to small intestinal cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-18) -
"I sound" - yoik as embodied health knowledge
(Doctoral thesis; Doktorgradsavhandling, 2023-08-17)Boares čállosat juoigama ja sámi kultuvrra birra govvidedje juoigama oassin buot eallima beliin sápmelaččas, leaš dál beaivválaš eallima doaimmain dahje vuoiŋŋalaš ja erenoamáš meanuin ja daguin. Juoigan govviduvvui dárbbašlažžan dearvvašvuhtii, čálgui ja lihkkui. Oanehaččat dadjon oažžot lohkat ahte luohti govviduvvui leame eallindárbun. Odne celket máŋga juoigi ahte luođis lea seamma mearkkašumi ... -
Kunnskapsoppsummering og klassifisering av tiltaket: VIP-Makkerskap (1. utg.)
(Journal article; Tidsskriftartikkel, 2023-04-04)Bakgrunn: VIP Makkerskap er et helsefremmende og universalforebyggende tiltak, som er utviklet for å sikre en bedre overgang fra ungdomsskolen til Vg1, og fra barne- til ungdomsskolen, for en bedre skolestart og for å fremme et godt læringsmiljø. VIP Makkerskap er utviklet og eiet av Vestre Viken HF/VIP psykisk helse i skolen, med finansiering fra Helsedirektoratet over tilskuddsordningen «Psykisk ... -
Kunnskapsoppsummering og klassifisering av tiltaket: VIP Snakk om det (2. utg.)
(Journal article; Tidsskriftartikkel, 2023-06-21)Bakgrunn: VIP Snakk om det (tidligere VIP-programmet) er et psykoedukativt program som retter seg mot elever i videregående skoler i alderen 16 og 17 år. Programmet gir informasjon om psykisk helse og psykiske lidelser samt veiledning i hvordan man håndterer slike vansker. Lærere og helsepersonell får opplæring i programmet og hvordan man oppdager problemer hos elevene tidlig for å kunne sette i ... -
Plasma levels of P-selectin and future risk of incident venous thromboembolism
(Journal article; Tidsskriftartikkel, 2023-05-12)Background - P-selectin levels are elevated following acute deep vein thrombosis and reported to predict recurrent venous thromboembolism (VTE) and cancer-associated VTE. Yet, it is unknown whether plasma P-selectin levels are associated with incident VTE.<p> <p>Objectives - We aimed to investigate the association between plasma P-selectin levels and risk of future incident VTE.<p> <p>Methods ... -
Overall lifestyle changes in adulthood are associated with cancer incidence in the Norwegian Women and Cancer Study (NOWAC) - a prospective cohort study
(Journal article; Tidsskriftartikkel, 2023-04-03)<p><i>Background:</i> Cancer is a leading cause of premature death worldwide and incidence is expected to rise in the coming decades. Many cohort studies, measuring lifestyle factors at one time-point, have observed that overall healthy lifestyles were inversely related to cancer incidence. However, there is little knowledge on the impact of lifestyle modification within adulthood. <p><i>Methods:</i> ... -
Measuring promotors of school functioning: Informing school-based psychosocial support for crisis-affected students in Lebanon
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-07)The evolving situation in Lebanon is characterized by multiple crises that affect education and can negatively affect a student’s school-functioning and mental health. The Ministry of Education and Higher Education decided in 2019 to further intensify and upscale implementation of school-based psychosocial support. This study is a contextualization and validation of the Student Learning in ... -
High-resolution visualization and assessment of basal and OXPHOS-induced mitophagy in H9c2 cardiomyoblasts
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-05)Mitochondria are susceptible to damage resulting from their activity as energy providers. Damaged mitochondria can cause harm to the cell and thus mitochondria are subjected to elaborate quality-control mechanisms including elimination via lysosomal degradation in a process termed mitophagy. Basal mitophagy is a house-keeping mechanism fine-tuning the number of mitochondria according to the metabolic ... -
Impact of multimodal interventions targeting behavior change on hand hygiene adherence in nursing homes: An 18-month quasi-experimental study
(Journal article; Tidsskriftartikkel, 2023-07-25)Background - Nursing home residents are vulnerable and frail, and hand hygiene adherence is often too low to prevent transmission of infections. This study’s aim was to investigate whether interventions targeting behavior change can improve hand hygiene adherence in nursing homes.<p> <p>Methods - Over 18 months, 22 nursing home wards participated in this quasi-experimental study. Three intervention ... -
ATPase activity of DFCP1 controls selective autophagy
(Journal article; Tidsskriftartikkel, 2023-07-08)Cellular homeostasis is governed by removal of damaged organelles and protein aggregates by selective autophagy mediated by cargo adaptors such as p62/SQSTM1. Autophagosomes can assemble in specialized cup-shaped regions of the endoplasmic reticulum (ER) known as omegasomes, which are characterized by the presence of the ER protein DFCP1/ZFYVE1. The function of DFCP1 is unknown, as are the mechanisms ... -
Exploring differentially expressed genes of Staphylococcus aureus exposed to human tonsillar cells using RNA sequencing
(Journal article; Tidsskriftartikkel, 2023-07-12)Background - The nose and the throat are the most predominant colonizing sites of Staphylococcus aureus, and colonization is a risk factor for infection. Nasal colonization is well described; however, we have limited knowledge about S. aureus throat colonization. The main objective of this study was to explore differentially expressed genes (DEGs) in S. aureus throat isolate TR145 exposed to human ...