English
norskDet helsevitenskapelige fakultet: Nye registreringer
Viser treff 1321-1340 av 10405
-
Medical school and self-reported practical skills: How do the UiT medical students acquire practical competence in emergency medicine skills?
(Master thesis; Mastergradsoppgave, 2021-05-28)Abstract Aims: To investigate how extracurricular healthcare-related (ECHR) work experience influenced University of Tromsø – The Arctic University of Norway’s medical students’ and graduates’ achieved level of practical training and their self-perceived confidence in selected practical skills believed to be important for emergency medicine. Materials and methods: Medical students and graduates ... -
Anticancer activity of amphipathic barbiturates
(Doctoral thesis; Doktorgradsavhandling, 2023-06-20)Cancer is one of the leading causes of death worldwide. Challenges related to drug resistance, side effects, and poor response rates makes cancer treatment complicated. However, different forms of immunotherapy have been effective for some cancer patients. Oncolytic therapies which can be administered directly intratumorally represent a promising form of immunotherapy. The aim of oncolytic therapies ... -
Amphipathic barbiturates as marine product mimics with cytolytic and immunogenic effects on head and neck squamous cell carcinoma cell lines
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-30)The incidence of head and neck squamous cell carcinoma (HNSCC) is increasing and the conventional treatments for this form of cancer can be tough. Despite the success of existing immunotherapies in some HNSCC patients, many do not respond to this type of treatment. Thus, the development of novel anti-cancer therapies should be prioritized. In the current study, the anticancer activity of a panel ... -
Lecithin and Chitosan as Building Blocks in Anti-Candida Clotrimazole Nanoparticles
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-25)The main focus when considering treatment of non-healing and infected wounds is tied to the microbial, particularly bacterial, burden within the wound bed. However, as fungal contributions in these microbial communities become more recognized, the focus needs to be broadened, and the remaining participants in the complex wound microbiome need to be addressed in the development of new treatment ... -
Drop-out and transfer-out intentions: The role of socio-cognitive factors
(Journal article; Tidsskriftartikkel, 2020-12-23)Academic attrition is a worldwide problem representing a significant economic loss and a disadvantage for students in terms of health and career prospects. We focus on the roles of academic skills, academic self-efficacy, and students' integration in exploring their relation to attrition intentions. Based on existing research, we expected a negative relation between academic skills and attrition ... -
Why do students leave? Student-related factors and attrition intentions
(Doctoral thesis; Doktorgradsavhandling, 2023-06-20)Established as a collection of scholars protecting their shared interests, higher education has become a driving force of economic development accountable to the government and society. However, changes in higher education have been accompanied by multiple challenges, including funding and quality assessment. This dissertation addresses one of these challenges facing academic institutions, academic ... -
SIRT1 - a new mammalian substrate of nuclear autophagy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-20)Macroautophagic/autophagic degradation of nuclear components (or nuclear autophagy) is a poorly understood area in autophagy research. We previously reported the nuclear lamina protein LMNB1 (lamin B1) as a nuclear autophagy substrate in primary human cells, stimulating the investigation of nuclear autophagy in the mammalian system. We recently reported the sirtuin protein SIRT1 as a new selective ... -
Late-onset sepsis in very preterm infants in Norway in 2009-2018: A population-based study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-02)Objective To evaluate epidemiology and outcomes among very preterm infants (<32 weeks’ gestation) with culture-positive and culture-negative late-onset sepsis (LOS).<p> <p>Design Cohort study using a nationwide, population-based registry. <p>Setting 21 neonatal units in Norway. <p>Participants All very preterm infants born 1 January 2009–31 December 2018 and admitted to a neonatal ... -
Low D-dimer levels at diagnosis of venous thromboembolism are associated with reduced risk of recurrence: data from the TROLL registry
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-31)Background: Venous thromboembolism (VTE) is a frequent disease with a high risk of recurrence. It has been suggested that the D-dimer level at the time of VTE diagnosis can be used to identify patients at a low risk of recurrence. Objectives: We aimed to investigate the impact of D-dimer levels measured at the time of VTE diagnosis on the risk of recurrence in a large cohort of patients with a ... -
The patient´s role in undergraduate health students' interprofessional clinical placements
(Doctoral thesis; Doktorgradsavhandling, 2023-06-16)Changed demographics and the prevalence of chronic, non-communicable, and infectious diseases create challenges in healthcare - lack of resources forces a transition from one-to-one to team-based approaches. Health professional education must prepare undergraduates for collaborative practice to ensure a collaborative-ready workforce that involves the patient as a partner. Interprofessional education ... -
D-dimer for diagnosis and risk assessment of first and recurrent venous thromboembolism
(Doctoral thesis; Doktorgradsavhandling, 2023-06-15)Venøs tromboembolisme (VTE) er en samlebetegnelse på dyp venetrombose (DVT) og lungeemboli. D-dimer, en blodprøve for koagulasjon og fibrinolyse, har vært en sentral del av VTE-diagnostikken i flere tiår. Blodprøven D-dimer har flere bruksområder og kan dermed reflektere ulike aspekter ved VTE. I denne avhandlingen har vi undersøkt i) om det er trygt og effektivt å bruke D-dimer uten samtidig bruk ... -
The liminal landscape of mentoring - Stories of physicians becoming mentors
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-14)<p><i>Introduction:</i> This study explores narratives of physicians negotiating liminality while becoming and being mentors for medical students. Liminality is the unstable phase of a learning trajectory in which one leaves behind one understanding but has yet to reach a new insight or position. <p><i>Methods:</i> In this study, we analysed semi-structural interviews of 22 physician mentors from ... -
Aktuelle forskningsområder for bioingeniører innen medisinsk biokjemi
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018)<p><i>Innledning.</i> Bioingeniørfaget er lite synlig i helsevesenet. Å identifisere forskningsområder innen biokjemisk laboratoriemedisin, kan være et ledd i å synliggjøre yrket. Mer forskning innen bioingeniørfaget er viktig for å kunne evaluere nye behandlingsteknikker, utvikle evidensbasert praksis og bedre pasientbehandling. Dette prosjektet er andre del av en studie som undersøker aktuelle ... -
The association between infant salivary cortisol and parental presence in the neonatal intensive care unit during and after COVID-19 visitation restrictions: A cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-07)Objectives: Parent-infant interaction in the neonatal intensive care unit (NICU) promotes health and reduces infant stress. During the COVID-19 pandemic, however, NICUs restricted parent-infant interaction to reduce viral transmission. This study examined the potential relationship between pandemic visitation restrictions, parental presence and infant stress as measured by salivary cortisol. Methods: ... -
Mentorering av medisinstudenter – en scoping review fra 2008 - 2018
(Master thesis; Mastergradsoppgave, 2018-05-23)<p><i>Innledning</i> Mentorprogrammer for medisinstudenter har vært en økende trend de siste 10 – 20 år, særlig innen medisinutdanning i Europa og Nord-Amerika. Fra tidligere er det publisert to litteraturgjennomganger av mentorprogrammer beskrevet i vitenskapelige artikler listet i Medline (1966 – 2002) og PubMed (2000 – 2008), hvor forfatterne identifiserte henholdsvis 9 og 14 formelle mentorprogrammer ... -
A highly selective purine-based inhibitor of CSF1R potently inhibits osteoclast differentiation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-28)The colony-stimulating factor 1 receptor (CSF1R) plays an important role in the regulation of many inflammatory processes, and overexpression of the kinase is implicated in several disease states. Identifying selective, smallmolecule inhibitors of CSF1R may be a crucial step toward treating these disorders. Through modelling, synthesis, and a systematic structure-activity relationship study, we ... -
Oral helse og sosial bakgrunn: En tverrsnittsstudie basert på den sjuende Tromsøundersøkelsen
(Mastergradsoppgave; Master thesis, 2021-05-19)Hensikten med denne masteroppgaven var å undersøke hvorvidt det er sammenheng mellom sosioøkonomisk status og tannhelse hos den voksne befolkningen i Tromsø. Materiale og metode. Datamateriale innhentet fra Tromsøundersøkelsen, Tromsø 7. Deltakerne besto av individer over 40 år som var bosatt i Tromsø kommune. Totalt var det 32 591 inviterte til å delta, hvorav 21 083 deltok i helseundersøkelsen. ... -
Weight change desire and dietary habits among young females and males in Tromsø and Balsfjord: The Fit Future 2 Study
(Mastergradsoppgave; Master thesis, 2022-05-18)It is not unusual for adolescents and young adults to have a desire to change their weight – either a desire to gain weight or reduce weight. Young men, on a general basis, want to increase their weight, while young women often want to decrease their weight. It is of concern that a larger number of both men and women with healthy weight wish to change their weight. In this thesis the aim was to ... -
Intake of marine fatty acids in early life and risk of celiac disease
(Mastergradsoppgave; Master thesis, 2021-05-18)Background: About 1% of the European population are affected by celiac disease (CD). Intake of omega-3 fatty acids in early life has been associated with lower risk of other immune-mediated diseases in children, but there are limited studies on CD. The primary aim of this thesis was to investigate if maternal intake of EPA and DHA during pregnancy, from food and/or supplements, was associated with ... -
The long-term effect of carbohydrate intake differing in quantity and quality on appetite in people with obesity - results from a randomized controlled trial (CARBFUNC)
(Mastergradsoppgave; Master thesis, 2021-05-17)Background: Overweight and obesity are major risk factors for å series of health consequences. A better understanding of appetite regulation can be an important part of providing treatment strategies. When weight is lost, several physiological adaptations, including changes in appetite, take place. Dietary composition seems to affect appetite, and both carbohydrate quantity and quality may play a ...
