Det helsevitenskapelige fakultet: Nye registreringer

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    • The ABC of academic procrastination: Functional analysis of a detrimental habit 

      Svartdal, Frode; Løkke, Jon Arne (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-03)
      Academic procrastination – habitually delaying work with academic tasks to the extent that the delays become detrimental to performance, wellbeing, and health – represents a substantial personal, systemic, and societal problem. Still, efforts to prevent and reduce it are surprisingly scarce and often offered as treatment regimens rather than preventive efforts. Based on the principles of ...

    • Samarbeid rundt oppfølging av kardiometabolske risikofaktorer hos mennesker med alvorlig psykisk lidelse i primærhelsetjenesten - En kvalitativ fokusgruppeintervjustudie 

      Klevstad, Marte Hykkerud (Mastergradsoppgave; Master thesis, 2020-11-02)
      Bakgrunn: Personer med alvorlig psykisk lidelse som schizofreni, bipolar lidelse og alvorlig depresjon har høyere morbiditets- og mortalitetsrate, enn befolkningen ellers. Dette skyldes delvis en dramatisk økt risiko for kardiometabolsk sykdom. Kunnskapsgrunnlaget om risikofaktorer er kompleks, men ikke fullstendig. Selv om mange risikofaktorer er kartlagte, er ikke overdødeligheten redusert. ...

    • Male and female immediate fear reaction to white noise in a semi-natural environment: A detailed behavioural analysis of the role of sex and oestrogen receptors 

      Le Moene, Olivia; Ramirez-Renteria, Mayra; Ågmo, Anders j (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-01)
      In classical rodent anxiety models, females usually display lower anxiety than males, whereas anxiety disorders are more prevalent in women. Perhaps this contradiction is caused by the use of behavioural models with low external validity. Therefore, we analysed immediate reactions to a sudden 90-dB white noise in a semi-natural environment. We observed mixed-sex groups of rats for the 60 seconds ...

    • Factors influencing mentors’ satisfaction: A study from medical schools in Norway and Canada 

      Skjevik, Elise Pauline; Schei, Edvin; Boudreau, J. Donald; Tjølsen, Arne; Ringberg, Unni; Fuks, Abraham; Kvernenes, Monika; Ofstad, Eirik H. (Master thesis; Mastergradsoppgave, 2020-11-01)
      <p><i>Phenomenon:</i> The mentoring of undergraduate medical students has been shown to benefit the mentors; however, detailed information on the factors that influence the satisfaction and motivation of mentors remains unclear. Such knowledge can be useful in sustaining group mentorship programs. The aim of this study was to investigate the experiences and perspectives of mentors to ascertain the ...

    • Diabetes nursing: Clinical and organizational knowledge as aspects of diabetes management in children with type 1 diabetes 

      Waldahl, Ingrid; Lauritzen, Vibeke (Conference object; Konferansebidrag, 2016-05)
      The background of this study is the world wide increase in type 1- diabetes in children. The international diabetes federation (IDF) estimates that approximately 500.000 children under the age of 15 have type 1- diabetes (1).

    • Er det regionale skilnader når det gjeld kommuneergoterapeutane i Noreg? 

      Gramstad, Astrid; Stigen, Linda; Maass, Ruca Elisa Katrin; Sveen, Unni; Horghagen, Sissel; Arntzen, Cathrine; Bonsaksen, Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-14)
      The aim of this study was to identify similarities and differences between the four health regions in Norway, with regards to the characteristics of occupational therapy staff working in the municipal health services. A cross-sectional study was performed where occupational therapists working in the municipalities were invited to fill out an online survey about the context of their work, work ...

    • The presentation and regulation of the IL-8 network in the epithelial cancer stem-like cell niche in patients with colorectal cancer 

      Cui, Guanglin; Li, Gui; Pang, Zhigang; Florholmen, Jon; Goll, Rasmus (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-07)
      Background: Accumulative evidence suggests that the biological behavior of cancer stem-like cells (CSCs) is regulated by their surrounding niche, in which cytokines function as one of the main mediators for the interaction between CSCs and their microenvironment in the colorectal cancer (CRC).<p> <p>Methods: We characterized the presentation of CSCs and the interleukin (IL)− 8 network in the ...

    • Smittevern i hjemmesykepleien - Mellom improvisasjon og faglig forsvarlighet? 

      Jensen, Linda Merete (Mastergradsoppgave; Master thesis, 2020-11-01)
      I tråd med Samhandlingsreformens intensjon mottar og behandler hjemmesykepleien en økende andel pasienter med infeksjonssykdommer. Mens sykehus og institusjoner er tilrettelagt for å kunne utøve smittevern, gjelder dette i langt mindre grad private hjem. For å lykkes med infeksjonsforebygging og - kontroll i hjemmene må sykepleierne minimalisere risikoen for smittespredning gjennom etterlevelse av ...

    • 'Søkelys på samfunnsmedisinen' : evaluering av kommunal samfunnsmedisinsk legetjeneste, offentlig legearbeid og de forebyggende oppgaver i fastlegeordningen 

      Pettersen, Betty; Johnsen, Roar (Research report; Forskningsrapport, 2005)
      Universitetet i Tromsø ved Institutt for Samfunnsmedisin har gjennom tre spørreskjemabaserte tverrsnittsundersøkelser studert kommunal samfunnsmedisinsk legetjeneste i forhold til arbeidsinnhold og arbeidsforhold før og etter Fastlegereformen, og hvilke faktorer som har påvirket utviklingen. Prosjektet inkluderer også intervjuer før og etter introduksjonen av reformen av kommunale administratorer, ...

    • Cost-effectiveness of molecularly matched off-label therapies for end-stage cancer–the MetAction precision medicine study 

      Ree, Anne Hansen; Mælandsmo, Gunhild Mari; Flatmark, Kjersti; Russnes, Hege Elisabeth Giercksky; Casteneda, Monica Gomez; Aas, Eline (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-09)
      Background: Precision cancer medicine (PCM), frequently used for the expensive and often modestly efficacious off-label treatment with medications matched to the tumour genome of end-stage cancer, challenges healthcare resources. We compared the health effects, costs and cost-effectiveness of our MetAction PCM study with corresponding data from comparator populations given best supportive care ...

    • Hip fractures in Norway – Inequity in treatment and outcomes 

      Kjærvik, Cato (Doctoral thesis; Doktorgradsavhandling, 2022-11-11)
      Målet med forskningsprosjektet var å belyse variasjon i behandling og utfall etter hoftebrudd i Norge, kartlegge forklaringer på og konsekvensene av variasjon, vurdere risikofaktorer for død etter hoftebrudd og deres relative betydning. I tillegg ønsket man å vurdere overlevelsesmønsteret og estimere varigheten av overdødelighet etter hoftebrudd. Prosjektet var en observasjonsstudie ...

    • High circulating levels of the homeostatic chemokines CCL19 and CCL21 predict mortality and disease severity in Covid-19 

      Tveita, Anders Aune; Murphy, Sarah Louise Mikalsen; Holter, Jan Cato; Kildal, Anders Benjamin; Michelsen, Annika Elisabet; Lerum, Tøri Vigeland; Kaarbø, Mari; Heggelund, Lars; Holten, Aleksander Rygh; Finbråten, Ane-Kristine; Muller, Karl Erik; Mathiessen, Alexander; Bøe, Simen; Fevang, Børre; Granerud, Beathe Kiland; Tonby, Kristian; Lind, Andreas; Dudman, Susanne; Nezvalova-Henriksen, Katerina; Müller, Fredrik; Skjønsberg, Ole Henning; Trøseid, Marius; Barratt-Due, Andreas; Riise, Anne Margarita Dyrhol; Aukrust, Pål; Halvorsen, Bente Evy; Dahl, Tuva Børresdatter; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-25)
      Background. Immune dysregulation is a major factor in the development of severe coronavirus disease 2019 (COVID-19). The homeostatic chemokines CCL19 and CCL21 have been implicated as mediators of tissue inflammation, but data on their regulation in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is limited. We thus investigated the levels of these chemokines in COVID-19 ...

    • CRISPR/Cas9 to Silence Long Non-Coding RNAs 

      Rosenlund, Ingrid A; Calin, George A.; Dragomir, Mihnea Paul; Knutsen, Erik (Chapter; Bokkapittel, 2021-06-24)
      Knock-out (KO) of long non-coding RNAs (lncRNAs) enables functional characterization of this still poorly described group of transcripts. One of the most efficient and simplest methods to achieve complete KO of a lncRNA is by employing CRISPR/Cas gene editing. As most lncRNAs are not well annotated, their individual functional regions are not defined, and the majority of the transcripts are not ...

    • Reciprocal relationships between personality disorders and eating disorders in a prospective 17-year follow-up study 

      Eielsen, Hanna Kristine Punsvik; Vrabel, KariAnne; Hoffart, Asle; Rø, Øyvind; Rosenvinge, Jan H (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-10)
      <p><b>Objective</b> This study aimed to report the presence of categorical and dimensional personality disorders (PD) in adults with longstanding eating disorders (ED) over a period of 17 years and to investigate whether changes in PD predict changes in ED symptoms or vice versa. <p><b>Methods</b> In total, 62 of the 80 living patients (78% response rate) with anorexia nervosa (<i>n</i> ...

    • Differences in time-critical interventions and radiological examinations between adult and older trauma patients: A national register-based study 

      Cuevas-Østrem, Mathias; Wisborg, Torben; Røise, Olav; Jeppesen, Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-07)
      BACKGROUND<p> <p>Older trauma patients are reported to receive lower levels of care than younger adults. Differences in clinical management between adult and older trauma patients hold important information about potential trauma system improvement targets. The aim of this study was to compare prehospital and early in-hospital management of adult and older trauma patients, focusing on time-critical ...

    • Movie and TV Depictions of Autism Spectrum Disorder 

      Nordahl-Hansen, Anders; Øien, Roald A (Chapter; Bokkapittel, 2017-11-30)
      This chapter focuses on the topic of character portrayals with autism spectrum disorders (ASD) in film and TV-series. We address this topic by presenting research from the general psychiatric field before we discuss the research on portrayals of characters with ASD. We will also provide the reader with some examples of films and TV-series that have been given particular attention in the popular media ...

    • The marine natural product mimic MPM-1 is cytolytic and induces DAMP release from human cancer cell lines 

      von Hofsten, Susannah; Paulsen, Marianne Hagensen; Magnussen, Synnøve; Ausbacher, Dominik; Kranz, Mathias; Bayer, Annette; Strøm, Morten Bøhmer; Berge, Gerd (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-16)
      Bioprospecting contributes to the discovery of new molecules with anticancer properties. Compounds with cytolytic activity and the ability to induce immunogenic cell death can be administered as intratumoral injections with the aim to activate anti-tumor immune responses by causing the release of tumor antigens as well as damage-associated molecular patterns (DAMPs) from dying cancer cells. In ...

    • Advanced topical delivery systems for membrane-active antimicrobials. Exploring nature to improve antimicrobial wound therapy 

      Hemmingsen, Lisa Myrseth (Doctoral thesis; Doktorgradsavhandling, 2022-11-11)
      Currently, approximately 2% of the general population will experience at least one chronic wound throughout their lifetime. The numbers are expected to rise due to an aging population with a heightened disease burden. These wounds are major burdens for the patients; therefore, we need to find innovative approaches for bacterial eradication and improved wound treatment. We aimed to utilize nature’s ...

    • Health anxiety as a continuous construct in the general population - measuring the distribution of health anxiety and the associations with healthcare use, physical disease and cardiovascular risk factors 

      Norbye, Anja Margrete Davis (Doctoral thesis; Doktorgradsavhandling, 2022-11-07)
      <p><i>Background:</i> Health anxiety (HA) concerns worry of disease, and has mostly been examined in people with severe HA/hypochondriasis. However, HA can be conceptualised as a continuous construct, with levels ranging from low to severe. There is little knowledge on the distribution of HA as a continuous construct in the general population, nor the association between different levels of HA and ...

    • The association between health anxiety, physical disease and cardiovascular risk factors in the general population – a cross-sectional analysis from the Tromsø study: Tromsø 7 

      Norbye, Anja Margrete Davis; Abelsen, Birgit; Førde, Olav Helge; Ringberg, Unni (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-02)
      Background: Health anxiety (HA) is defined as a worry of disease. An association between HA and mental illness has been reported, but few have looked at the association between HA and physical disease. Objective: To examine the association between HA and number of diseases, different disease categories and cardiovascular risk factors in a large sample of the general population.<p> <p>Methods: ...