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norskDet helsevitenskapelige fakultet: Nye registreringer
Viser treff 2021-2040 av 10407
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The effect of Riociguat on cardiovascular function and efficiency in healthy, juvenile pigs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-12)<p><i>Introduction - </i>Riociguat is a soluble guanylate cyclase stimulator approved for the treatment of pulmonary hypertension. Its effect on cardiometabolic efficiency is unknown. A potential cardiac energy sparing effect of this drug could imply a positive prognostic effect, particularly in patients with right heart failure from pulmonary hypertension. <p><i>Method - </i>We infused Riociguat ... -
Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-06)PoxtA and OptrA are ATP binding cassette (ABC) proteins of the F subtype (ABCF). They confer resistance to oxazolidinone and phenicol antibiotics, such as linezolid and chloramphenicol, which stall translating ribosomes when certain amino acids are present at a defined position in the nascent polypeptide chain. These proteins are often encoded on mobile genetic elements, facilitating their rapid ... -
Academic Self-Efficacy, Procrastination, and Attrition Intentions
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-24)Why do students leave universities? The current study addresses the problem of academic attrition from the perspective of students’ intentions. Specifically, we focus on the roles of academic self-efficacy and procrastination in exploring their relationships with attrition intentions. Based on existing research, we expected a negative relationship between academic self-efficacy and attrition ... -
miR-101-5p Acts as a Tumor Suppressor in HER2-Positive Breast Cancer Cells and Improves Targeted Therapy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-01)Purpose: Human epidermal growth factor receptor 2 positive (HER2+) breast cancers responding poorly to targeted therapy need improved treatment options. miR-101-5p has shown tumor-suppressive properties in multiple cancer forms, and we assessed the effect and mechanism of action of this miRNA in HER2+ breast cancer.<p> <p>Methods: Expression levels of miR-101-5p in two clinical datasets, TCGA and ... -
The Interaction Between Venous Thromboembolism and Socioeconomic Status on the Risk of Disability Pension
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-14)Background: Venous thromboembolism (VTE) is associated with increased risk of disability pension. How socioeconomic status (SES) impacts the risk of disability pension after a VTE is unknown. The aim of this nationwide population based cohort study to investigate the interaction between SES and incident VTE on the risk of subsequent disability pension.<p> <p>Methods: Using Danish national medical ... -
Explaining sex differences in risk of bloodstream infections using mediation analysis in the population-based HUNT study in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-19)Previous studies indicate sex differences in incidence and severity of bloodstream infections (BSI). We examined the effect of sex on risk of BSI, BSI mortality, and BSI caused by the most common infecting bacteria. Using causal mediation analyses, we assessed if this effect is mediated by health behaviours (smoking, alcohol consumption), education, cardiovascular risk factors (systolic blood pressure, ... -
Clinical characteristics, mortality and pain tolerance in stable versus acute presentation of coronary heart disease
(Doctoral thesis; Doktorgradsavhandling, 2022-09-30)<p>Despite immense progress in the prevention, diagnosis and treatment of coronary heart disease, several challenges remain. In more than half of patients referred to coronary angiography for stable and unstable angina, no obstructive coronary artery disease (CAD) is found. At the same time, some patients present for the first time with already extensive CAD. Further, the management of unstable ... -
Prevalence, vascular complications, and level of health care treatment in individuals with type 2 and type 1 diabetes mellitus
(Doctoral thesis; Doktorgradsavhandling, 2022-10-04)The total prevalence of diabetes and vascular complications is increasing. Consequently, it is important to provide diabetes treatment according to the National clinical guideline for the management of diabetes and allocate individuals to the right level of health care in line with the National guideline for prioritization in specialist health care – Endocrinology and endocrine surgery. We used data ... -
Tiltak i grunnutdanningen for å sikre legertil distrikt – en systematisk oversikt
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-11)BAKGRUNN - Rekruttering av leger til distrikt er utfordrende. Ulike utdanningstiltak for å sikre leger til distrikt er etablert i mange land. Målet med denne studien var å samle kunnskap om hvilke tiltak i grunnutdanningen av leger som er etablert for å bidra til distriktsrekruttering, og hvilke resultater disse tiltakene har gitt.<p> <p>KUNNSKAPSGRUNNLAG - Vi gjorde et systematisk søk i ... -
Interleukin 33: a locally induced alarmin in the colonic mucosa of ulcerative colitis
(Doctoral thesis; Doktorgradsavhandling, 2022-09-27)Ulcerative colitis (UC) is a chronic inflammatory bowel disease involving the mucosal lining of the large bowel (colon and rectum). Common symptoms include bouts of diarrhoea, rectal bleeding and abdominal pain. The pathogenesis of UC is complex and multifactorial. This thesis investigated interleukin 33 (IL-33), an alarmin of the innate immune system. IL-33 is of interest as it is found to be ... -
General Measurement Tools for Assessing Mental Health Problems Among Children and Adolescents with an Intellectual Disability: A Systematic Review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-12)Introduction: Cognitive impairment is one of the main disabilities in dementia. Physical activity (PA) has been suggested as protective for dementia. However, the findings are disparate in studies, and the question of whether this is because of reverse causality is still open. We aimed to explore the association of PA with cognition in people who later developed dementia compared to those who ... -
Professionals' narratives of interactions with patients' families in intensive care
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-24)Background: ICU patients’ family members are in a new, uncertain, and vulnerable situation due to the patient’s critical illness and complete dependence on the ICU nurses and physicians. Family members’ feeling of being cared for is closely linked to clinicians’ attitudes and behavior.<p> <p>Aim: To explore ICU nurses’ and physicians’ bedside interaction with critically ill ICU patients´ families ... -
Characterization and Fitness Cost of Tn7100, a Novel Integrative and Conjugative Element Conferring Multidrug Resistance in Haemophilus influenzae
(Journal article; Tidsskriftartikkel, 2022-07-22)A multidrug-resistant (MDR) strain of Haemophilus influenzae, Hi-228, with phenotypic resistance toward ampicillin, cefotaxime, chloramphenicol, gentamicin, and azithromycin, was isolated in Oslo, Norway. The strain was part of a clonal outbreak (2016–2017) comprising five ST143 strains with identical resistotypes. Hi-228 carries a novel integrative and conjugative element (ICE), Tn7100, contributing ... -
Safety and use of complementary and alternative medicine in Norway during the first wave of the COVID-19 pandemic using an adapted version of the I-CAM-Q; a cross-sectional survey
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-03)Background: The COVID-19 pandemic lockdown has had a profound impact on physical and mental well-being throughout the world. Previous studies have revealed that complementary and alternative medicine (CAM) is frequently used for, and can be potential benefcial for strengthening physical mental resilience. The aims of this study were therefore to determine the prevalence and reasons for use of CAM ... -
The Healthy Body Image intervention and reduction in eating disorder symptomatology and muscle building supplement use in high school students: a study of mediating factors
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-28)Background: Mediation analysis is important to test the theoretical framework underpinning an intervention. We therefore aimed to investigate if the healthy body image (HBI) intervention’s effect on eating disorder (ED) symptomatology and use of muscle building supplements was mediated by the change in risk and protective factors for ED development and muscle building supplement use. <p> <p>Methods: ... -
Composite immune marker scores associated with severe mental disorders and illness course
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-02)Background: Low-grade inflammation has been implicated in the pathophysiology of severe mental disorders (SMDs) and a link between immune activation and clinical characteristics is suggested. However, few studies have investigated how patterns across immune markers are related to diagnosis and illness course.<p > <p>Methods: A total of 948 participants with a diagnosis of schizophrenia (SCZ, N ... -
Early screening outcomes among non-immigrants and immigrants targeted by BreastScreen Norway, 2010–2019
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-31)Aims: This study aimed to analyse results on early screening outcomes, including recall and cancer rates, and histopathological tumour characteristics among non-immigrants and immigrants invited to BreastScreen Norway. Methods: We included information about 2, 763,230 invitations and 2,087,222 screening examinations from 805,543 women aged 50–69 years who were invited to BreastScreen Norway between ... -
Chemical and Enzyme-Assisted Extraction of Fucoidan from two Species of Brown Macroalgae (Ascophyllum nodosum and Saccharina latissima)
(Conference object; Konferansebidrag, 2022)Macroalgae are vital species and are known to produce a wide range of bioactive compounds including polysaccharides, such as fucoidan. Traditionally, these compounds are extracted using hazardous solvents that leads to environmental pollution and waste. Considering this, more sustainable technologies are being investigated as greener alternatives.<p> <p>The main goal of this study was to ... -
Digital hjemmeoppfølging og ressursbruk i primær- og spesialisthelsetjenesten: en systematisk oversikt
(Research report; Forskningsrapport, 2022-04)Velferdsteknologi, inkludert digital hjemmeoppfølging, er et viktig element i utviklingen av helse- og omsorgssektoren. Formålet med denne systematiske oversikten var å undersøke effekter av digital hjemmeoppfølging for voksne med ikke-smittsomme kroniske sykdommer mht. ressursbruk i primær- og spesialisthelsetjenesten. Digital hjemmeoppfølging i denne oversikten innebærer forhåndsavtalte helserelaterte ... -
Predictors of extubation success: a population-based study of neonates below a gestational age of 26 weeks
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-09)Objective The aim of the study was to investigate first extubation attempts among extremely premature (EP) infants and to explore factors that may increase the quality of clinical judgement of extubation readiness. Design and method A population-based study was conducted to explore first extubation attempts for EP infants born before a gestational age (GA) of 26 weeks in Norway between 1 January ...
