Viser treff 2121-2140 av 10412

    • Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis 

      Bouras, Emmanouil; Karhunen, Ville; Gill, Dipender; Huang, Jian; Haycock, Philip C.; Gunter, Marc J.; Johansson, Mattias; Brennan, Paul; Key, Tim; Lewis, Sarah J.; Martin, Richard M.; Murphy, Neil; Platz, Elizabeth A.; Travis, Ruth; Yarmolinsky, James; Zuber, Verena; Martin, Paul; Katsoulis, Michail; Freisling, Heinz; Nøst, Therese Haugdahl; Schulze, Matthias B.; Dossus, Laure; Hung, Rayjean J.; Amos, Christopher I.; Ahola-Olli, Ari; Palaniswamy, Saranya; Männikkö, Minna; Auvinen, Juha; Herzig, Karl-Heinz; Keinänen-Kiukaanniemi, Sirkka; Lehtimäki, Terho; Salomaa, Veikko; Raitakari, Olli; Salmi, Marko; Jalkanen, Sirpa; Jarvelin, Marjo-Riitta; Dehghan, Abbas; Tsilidis, Konstantinos K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-11)
      Background - Epidemiological and experimental evidence has linked chronic inflammation to cancer aetiology. It is unclear whether associations for specific inflammatory biomarkers are causal or due to bias. In order to examine whether altered genetically predicted concentration of circulating cytokines are associated with cancer development, we performed a two-sample Mendelian randomisation (MR) ...
    • Socioeconomic inequalities in physiological risk biomarkers and the role of lifestyles among Russians aged 35-69 years 

      Trias-Llimós, Sergi; Cook, Sarah; Eggen, Anne Elise; Kudryavtsev, Alexander V; Malyutina, Sofia; Shkolnikov, Vladimir M.; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-15)
      Background: Socioeconomic inequalities in cardiovascular (CVD) health outcomes are well documented. While Russia has one of the highest levels of CVD mortality in the world, the literature on contemporary socio-economic inequalities in biomarker CVD risk factors is sparse. This paper aims to assess the extent and the direction of SEP inequalities in established physiological CVD risk biomarkers, ...
    • Risk factors of anemia among preschool children in Ethiopia: a Bayesian geo-statistical model 

      Endris, Bilal Shikur; Dinant, Geert-Jan; Hagos, Seifu; Spigt, Marcus (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-07)
      Background - The etiology and risk factors of anemia are multifactorial and varies across context. Due to the geospatial clustering of anemia, identifying risk factors for anemia should account for the geographic variability. Failure to adjust for spatial dependence whilst identifying risk factors of anemia could give spurious association. We aimed to identify risk factors of anemia using a Bayesian ...
    • Are pro-inflammatory markers associated with psychological distress in a cross-sectional study of healthy adolescents 15–17 years of age? The Fit Futures study 

      Linkas, Jonas; Ahmed, Luai A.; Csifcsak, Gabor; Emaus, Nina; Furberg, Anne-Sofie; Grimnes, Guri; Pettersen, Gunn; Rognmo, Kamilla; Christoffersen, Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-15)
      Background - Inflammatory markers have been associated with depression and anxiety disorder in adolescents. Less is known about the association between inflammation and subclinical symptoms in the form of psychological distress. We investigated prevalence of psychological distress and examined the associations between common pro-inflammatory markers and psychological distress in an adolescent ...
    • Is amalgam removal in patients with medically unexplained physical symptoms cost-effective? A prospective cohort and modelling study in Norway 

      Lamu, Admassu Nadew; Björkman, Lars; Hamre, Harald Johan; Alræk, Terje; Musial, Frauke; Robberstad, Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-29)
      There are many patients in general practice with health complaints that cannot be medically explained. Some of these patients attribute their health complaints to dental amalgam restorations. This study examined the cost-effectiveness of the removal of amalgam restorations in patients with medically unexplained physical symptoms (MUPS) attributed to amalgam fillings compared to usual care, based ...
    • Association between cannabis use and physical health problems in Norwegian adolescents: a cross-sectional study from the youth survey Ungdata 

      Mæland, Ragnhild; Lien, Lars; Leonhardt, Marja (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-06)
      Background - Cannabis use is increasing among young Norwegians and several studies show a high incidence of common physical health problems. An association has previously been found between cannabis use and mental health problems. Since physical and mental health problems often co-occur, the aim of this study is to explore the relationship between cannabis use and physical health problems.<p> <p>Methods ...
    • From fixed-dried to wet-fixed to live-comparative super-resolution microscopy of liver sinusoidal endothelial cell fenestrations 

      Szafranska, Karolina; Neuman, Tanja; Baster, Zbigniew; Rajfur, Zenon; Szelest, Oskar; Holte, Christopher Florian; Kubisiak, Agata; Kus, Edyta; Wolfson, Deanna; Chlopicki, Stefan; Ahluwalia, Balpreet Singh; Lekka, Malgorzata; Szymonski, Marek; McCourt, Peter Anthony; Zapotoczny, Barlomiej (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-20)
      Fenestrations in liver sinusoidal endothelial cells (LSEC) are transcellular nanopores of 50–350 nm diameter that facilitate bidirectional transport of solutes and macromolecules between the bloodstream and the parenchyma of the liver. Liver diseases, ageing, and various substances such as nicotine or ethanol can negatively influence LSECs fenestrations and lead to defenestration. Over the years, ...
    • Norwegian Open Fracture Management System: Outcomes after 10 Years Working in Low-Resource Settings in Cambodian Hospitals 

      Tajsic, Nenad; Sørbye, Sigrunn Holbek; Nguon, Sophy; Sokh, Vannara; Lim, Aymeric (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-13)
      Introduction: The treatment of open lower limb fractures represents a major challenge for any trauma surgeon, and this even more so in resource-limited areas. The aim of the study is to describe the intervention, report the treatment plan, and observe the effectiveness of the Norwegian Open Fracture Management System in saving lower limbs in rural settings.<p> <p>Materials and Methods: A ...
    • Disassembly and Mislocalization of AQP4 in Incipient Scar Formation after Experimental Stroke 

      Banitalebi, Shervin; Skauli, Nadia; Geiseler, Samuel; Ottersen, Ole Petter; Amiry-Moghaddam, Mahmood (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-20)
      There is an urgent need to better understand the mechanisms involved in scar formation in the brain. It is well known that astrocytes are critically engaged in this process. Here, we analyze incipient scar formation one week after a discrete ischemic insult to the cerebral cortex. We show that the infarct border zone is characterized by pronounced changes in the organization and subcellular ...
    • AXL inhibition improves BRAF-targeted treatment in melanoma 

      Nyakas, Marta Sølvi; Fleten, Karianne Giller; Haugen, Mads Haugland; Engedal, Nikolai; Sveen, Christina; Farstad, Inger Nina; Flørenes, Vivi Ann; Prasmickaite, Lina; Mælandsmo, Gunhild Mari; Vasiliauskaite, Kotryna (Journal article; Tidsskriftartikkel; Peer reviewed, 2022)
      More than half of metastatic melanoma patients receiving standard therapy fail to achieve a long-term survival due to primary and/or acquired resistance. Tumor cell ability to switch from epithelial to a more aggressive mesenchymal phenotype, attributed with AXL<sup>high</sup> molecular profle in melanoma, has been recently linked to such event, limiting treatment efcacy. In the current study, ...
    • Conventional health care service utilization among cancer survivors that visit traditional and complementary providers in the Tromsø study: a cross-sectional study 

      Nakandi, Kiwumulo; Mora, Dana Catalina; Stub, Trine; Kristoffersen, Agnete Egilsdatter (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-11)
      Background: Traditional and complementary medicine (T&CM) is commonly used among cancer patients worldwide. Cancer patients in Norway mainly visit T&CM providers in addition to conventional health care services. It is not known how their utilization of T&CM providers influences their use of conventional health care services. The aim of this study was to investigate the difference between the ...
    • Perceptions of the academic learning environment among occupational therapy students – changes across a three-year undergraduate study program 

      Stigen, Linda; Mørk, Gry; Carstensen, Tove; Magne, Trine A; Gramstad, Astrid; Johnson, Susanne Grødem; Småstuen, Milada Cvancarova; Bonsaksen, Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-25)
      Introduction: Although the learning environment influences students’ motivation, learning outcomes, and satisfaction with the study program, less is known about how these factors change as the students’ progress through the study program.<p> <p>Aim: The aim of this study was to examine changes in occupational therapy students’ perceptions of the academic learning environment during their three-year ...
    • Self-reported mental health status of pregnant women in Sweden during the COVID-19 pandemic: a cross-sectional survey 

      Ho-Fung, Chung; Andersson, Ewa; Hsuan-Ying, Huang; Acharya, Ganesh; Schwank, Simone (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-28)
      Background: The COVID-19 pandemic has contributed to unprecedented worries and challenges for pregnant women due to social restrictions and changes in maternity care provision. We aimed to investigate the mental health impact of COVID-19 pandemic on pregnant women in Sweden and explore factors associated with poor perinatal mental health in this specifc context.<p> <p>Method: This was a nation-wide ...
    • Tannhelsetjenester i norske fengsler. En spørreundersøkelse blant fengselsansatte og fengselstannleger 

      Stein, Linda; Bondø, Therese; Endresen, Erika Hauglid; Berggren, Tiril (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-02)
      <p>Undersøkelser fra andre land har vist at innsatte i fengsler generelt har dårlig tannhelse og stort behandlingsbehov. Det finnes imidlertid lite informasjon om dette i Norge. Hensikten med studien var å kartlegge forhold som påvirker tannhelsetjenester til innsatte i norske fengsler og undersøke fengselsansattes og fengselstannlegers holdninger til tilbudet. Elektroniske spørreskjemaer ble ...
    • Mellom hypoteser og tilfeldigheter 

      Lund, Eiliv (Others; Andre, 2017)
      Dette er en personlig, objektiv beskrivelse av grunnlaget for Kvinner og Kreft, utviklingen over tid og samspillet mellom ideer, engasjement og tilfeldigheter. Over ca femti år er det meste forandret fra forskning drevet av nysgjerrighet til forskning som konkurranse. Det springende spørsmål er hva som gir best utbytte i fremtiden? Prosjekter har ofte en meget lang tidshorisont. Politiske og ...
    • How docetaxel entrapment, vesicle size, zeta potential and stability change with liposome composition–A formulation screening study 

      Holsæter, Ann Mari; Wizgird, Kristina; Karlsen, Iselin; Hemmingsen, Jeanette Frimand; Brandl, Martin; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-21)
      Limitations of the anticancer drug product Taxotere® have encouraged researchers to entrap the active ingredient docetaxel (DTX) into nanocarriers such as liposomes. However, until now no DTX-liposome formulation has reached the clinic. Hence, in the present study, different Soy-PC based DTX-liposome formulations were screened in an attempt to identify lipid-compositions with promising DTX-entrapment ...
    • Supplementation with a probiotic mixture accelerates gut microbiome maturation and reduces intestinal inflammation in extremely preterm infants 

      Samara, Jumana; Moossavi, Shirin; Alshaikh, Belal; Ortega, Van A.; Pettersen, Veronika K.; Ferdous, Tahsin; Hoops, Suzie L.; Soraisham, Amuchou; Vayalumkal, Joseph; Dersch-Mills, Deonne; Gerber, Jeffrey S.; Mukhopadhyay, Sagori; Puopolo, Karen; Tompkins, Thomas A.; Knights, Dan; Walter, Jens; Amin, Harish; Arrieta, Marie-Claire (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-11)
      Probiotics are increasingly administered to premature infants to prevent necrotizing enterocolitis and neonatal sepsis. However, their effects on gut microbiome assembly and immunity are poorly understood. Using a randomized intervention trial in extremely premature infants, we tested the effects of a probiotic product containing four strains of Bifidobacterium species autochthonous to the infant ...
    • The association between preoperative MRI findings and clinical improvement in patients included in the NORDSTEN spinal stenosis trial 

      Aaen, Jørn Ståle; Banitalebi, Hasan; Austevoll, Ivar Magne; Hellum, Christian; Storheim, Kjersti; Myklebust, Tor Åge; Anvar, Masoud D; Weber, Clemens; Solberg, Tore; Grundnes, Oliver; Brisby, Helena; Indrekvam, Kari; Hermansen, Erland (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-05)
      <p><b>Purpose</b> To investigate potential associations between preoperative MRI findings and patient reported outcome measures (PROMs) after surgery for lumbar spinal stenosis (LSS). <p><b>Methods</b> The NORDSTEN trial included 437 patients. We investigated the association between preoperative MRI findings such as morphological grade of stenosis (Schizas grade), quantitative grade of ...
    • The relationship between smokeless tobacco (snus) and anxiety and depression among adults and elderly people. A comparison to smoking in the Tromsø Study 

      Bondø, Pia; Høye, Anne; Løchen, Maja-Lisa; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed; Master thesis; Mastergradsoppgave, 2022-05-23)
      <p><b>Aims</b> To (i) define the characteristics of snus users compared with non-users and smokers and (ii) define the relationship between snus use and self-reported anxiety and depression and compare it with the relation between smoking and anxiety and depression. <p><b>Design, setting and participants</b> A cross-sectional study based on data from the Norwegian population-based survey, ...
    • Are Personality Traits Related to how Healthy Adults Adjust Their Decision-Making Strategies Under Varying Levels of Reward and Loss Controllability? 

      Angen, Caroline Alexandra Grant (Mastergradsoppgave; Master thesis, 2022-05-16)
      Abstract Research suggests a dual-system theory of motivation on decision-making in humans, consisting of the Pavlovian and the Instrumental systems. These systems influence how we respond to environmental threats and rewards either in an automatic or in a more deliberate manner, and their interaction can either optimize or hinder decision-making. Importantly, humans seem to rely more heavily on ...