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Prevalence of anemia and its associated factors among pregnant women in Georgia
(Mastergradsoppgave; Master thesis, 2021-05-31)The WHO currently considers maternal anemia global public health concern, and one of the most common complications during pregnancy. Symptoms range from weakness and fatigue, to serious cardiac complications. Maternal anemia also poses a risk to the infant, as it can increase the likelihood of preterm birth and low birth weight babies, among additional concerns. Past research is primarily focused ... -
Diagnostics and management of infective endocarditis post-transcatheter aortic valve implantation - A systematic review
(Master thesis; Mastergradsoppgave, 2021-05-31)Background: As transcatheter aortic valve implantation (TAVI) has expanded the treatment options to otherwise inoperable patients, it has become as prevalent as surgical aortic valve replacement. TAVI infective endocarditis (IE) has thereby become a feared complication. IE is heterogenous in its presentation, identifying characteristics and diagnostic criteria among these patients is crucial in ... -
The association between smoking and the risk of pancreatic cancer - The Norwegian women and cancer (NOWAC) study
(Mastergradsoppgave; Master thesis, 2021-05-31)Aims To examine the strength of association between cigarette smoking and the risk of pancreatic cancer in a cohort of Norwegian women. Methods A total of 149,243 women from Norwegian Women and Cancer Study were included in the statistical analysis. The participants were followed using the Cancer Registry of Norway and Norwegian Central Population Register till they were diagnosed with cancer, ... -
Forekomst av akutt nyreskade ved Finnmarkssykehuset
(Master thesis; Mastergradsoppgave, 2021-05-29)Ifølge litteraturen øker forekomsten av akutt nyreskade (AKI). Vi ønsket å undersøke forekomsten ved et norsk sykehus, i hvilken grad tilstanden ble kodet, om det var ulik forekomst hos menn og kvinner, samt hos Hammerfest og Kirkenes sykehus. Oppgaven var en retrospektiv kasus-kontrollstudie, basert på uttrekksdata fra Finnmarkssykehuset, med opplysninger om innlagte pasienter i 2008 og 2018. ... -
A Comparison Between Office Blood Pressure Measurements and Ambulatory Blood Pressure Measurements in the Healthy Middle-Aged General Population
(Master thesis; Mastergradsoppgave, 2019-05-29)Background: Ambulatory blood pressure measurements are frequently lower compared to office measurements. Our aims were to investigate the relationship between office blood pressure measurements and ambulatory measurements and to quantify the difference between the two methods. Methods: This study included 1608 participants aged 50 – 62 years from the municipality of Tromsø, Norway. Office blood ... -
Staphylococcus aureus nasal carriage in relation to iron status in a Norwegian adolescent population
(Mastergradsoppgave; Master thesis, 2020-05-29)Staphylococcus aureus (S. aureus) needs iron to survive and replicate and has evolved systems to harvest iron from its host. In humans, excess iron could potentially increase the risk of S. aureus carriage and infections. Moreover, iron plays a vital role in the development and function of the host immune system. Adolescence is a growth spurt period with increased iron requirements. The aim of this ... -
Peripheral blood cells inform on the presence of breast cancer: A population‐based case–control study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-06-14)Tumor–host interactions extend beyond the local microenvironment and cancer development largely depends on the ability of malignant cells to hijack and exploit the normal physiological processes of the host. Here, we established that many genes within peripheral blood cells show differential expression when an untreated breast cancer (BC) is present, and harnessed this fact to construct a 50-gene ... -
The immunophilin Zonda controls regulated exocytosis in endocrine and exocrine tissues
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-18)Exocytosis is a fundamental process in physiology, that ensures communication between cells, organs and even organisms. Hormones, neuropeptides and antibodies, among other cargoes are packed in exocytic vesicles that need to reach and fuse with the plasma membrane to release their content to the extracellular milieu. Hundreds of proteins participate in this process and several others in its regulation. ... -
The pH-Responsive Liposomes—The Effect of PEGylation on Release Kinetics and Cellular Uptake in Glioblastoma Cells
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-25)Nanomedicine has been, to a certain degree, a success story in the development of superior anticancer therapies. However, there are tumors that remain a huge challenge for nanoformulations, for instance, brain tumors such as glioblastoma, the most common and aggressive brain tumor. To utilize the fact that such tumors are characterized by an acidic extracellular environment, we selected pH-responsive ... -
Inverse PCR-based detection reveal novel mobile genetic elements and their associated genes in the human oral metagenome
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-27)The human oral cavity is one of the hotspots harboring multiple mobile genetic elements (MGEs), which are segments of DNA that can move either within bacterial genomes or between bacterial cells that can facilitate the spreading of genetic materials, including antimicrobial resistance genes. It is, therefore, important to investigate genes associated with the MGEs as they have a high probability of ... -
Prediction of outcome in patients with severe aortic stenosis treated with transcatheter aortic valve implantation
(Doctoral thesis; Doktorgradsavhandling, 2022-06-17)Surgical aortic valve replacement (SAVR) has until the last decade been the standard treatment for patients with aortic stenosis (AS). However, many patients were not offered surgical treatment due to high age or unacceptable surgical risk estimated by surgical risk scores. Transcatheter aortic valve implantation (TAVI) is a less invasive treatment modality where the valve is implanted using a ... -
The associations of alcohol consumption with smoking cessation and weight change
(Mastergradsoppgave; Master thesis, 2020-05-27)Alcohol consumption, overweight and smoking are associated with premature mortality. These behaviors tend to co-occur and often differ between different socioeconomic groups. Previous studies have indicated a reversed social gradient in total alcohol consumption. The main purpose of this repeated-measures study was to investigate the social gradient in total alcohol consumption and its relationship ... -
Microscopy Meets Nanomedicine: The Challenge of Liposomes. Selecting, Understanding, and Adapting Imaging Techniques to Localize and Characterize Nanocarriers
(Doctoral thesis; Doktorgradsavhandling, 2022-06-10)Nanocarriers have brought several medical advances through better diagnostics and improved drug therapy. Yet, many promising preclinical findings were never translated into clinical success, consequently slowing drug development, and increasing its financial burden. By reliably predicting the nanoparticle fate at in vitro stages, the disappointment of suboptimal in vivo outcome could be avoided. To ... -
ATG8 Family Proteins Act as Scaffolds for Assembly of the ULK Complex SEQUENCE REQUIREMENTS FOR LC3-INTERACTING REGION (LIR) MOTIFS
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012-10-05)Autophagy is a lysosome-dependent degradation system conserved among eukaryotes. The mammalian Atg1 homologues, Unc-51 like kinase (ULK) 1 and 2, are multifunctional proteins with roles in autophagy, neurite outgrowth, and vesicle transport. The mammalian ULK complex involved in autophagy consists of ULK1, ULK2, ATG13, FIP200, and ATG101. We have used pulldown and peptide array overlay assays to ... -
Nursing during World War II: Finnmark County, Northern Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013-04-25)Introduction. This study is part the project ‘‘Nursing in Borderland Finnmark 19391950’’ within nursing history that sheds light on nursing and health care during World War II in Finnmark County, Northern Norway. The study focuses on challenges in nursing care that arose during the war because of war activities in the Barents area. This article focuses on challenges caused by shortage of supplies. ... -
Effect of caudal epidural steroid or saline injection in chronic lumbar radiculopathy: multicentre, blinded, randomised controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)Objective To assess the efficacy of caudal epidural steroid or saline injection in chronic lumbar radiculopathy in the short (6 weeks), intermediate (12 weeks), and long term (52 weeks).<p> <p>Design Multicentre, blinded, randomised controlled trial. <p>Setting Outpatient multidisciplinary back clinics of five Norwegian hospitals. <p>Participants Between October 2005 and February 2009, 461 ... -
The effect of transcranial direct current stimulation on the interplay between executive control, behavioral variability and mind wandering: A registered report
(Mastergradsoppgave; Master thesis, 2022-03-31)Mind wandering (MW) is a mental phenomenon humans experience daily. Yet, we lack a complete understanding of the neural basis of this pervasive mental state. Over the past decade there has been an increase in publications using transcranial direct current stimulation (tDCS) to modulate the propensity to mind wander, but findings are diverse, and a satisfactory conclusion is missing. Recently, Boayue ... -
Does the Stereotypicality of Mothers’ Occupation Influence Children’s Communal Occupational Aspirations and Communal Orientation?
(Mastergradsoppgave; Master thesis, 2022-02-10)Career development is a lifelong process that starts in infancy and is shaped by a number of different factors during childhood, adolescence, and adulthood. Even though career development is shaped through life, relatively little is known about the predictors of occupational aspirations in childhood. Therefore, in the present work we investigate how the stereotypicality of a mother’s occupation ... -
Protein homeostasis in LGMDR9 (LGMD2I) – The role of ubiquitin‐proteasome and autophagy‐lysosomal system
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-18)Aims: Limb-girdle muscular dystrophy R9 (LGMDR9) is an autosomal recessive disorder caused by mutations in the fukutin-related protein gene (FKRP), encoding a glycosyltransferase involved in α-dystroglycan modification. Muscle atrophy, a significant feature of LGMDR9, occurs by a change in the normal balance between protein synthesis and protein degradation. The ubiquitin–proteasome system (UPS) ... -
Combining education and income into a socioeconomic position score for use in studies of health inequalities
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-13)Background: In studies of social inequalities in health, there is no consensus on the best measure of socioeconomic position (SEP). Moreover, subjective indicators are increasingly used to measure SEP. The aim of this paper was to develop a composite score for SEP based on weighted combinations of education and income in estimating subjective SEP, and examine how this score performs in predicting ...
