<i>Background</i>: Many children and adolescents experience violent events which can be associated with negative consequences for their development, mental health, school, and social functioning. However, findings between settings and on the role of gender have been inconsistent. This study aimed to investigate cross-country and gender differences in the relationship between community violence ...

Breast cancer is the most common cancer in women today, and although many risk factors are known, these cannot fully explain the vast increase in breast cancer incidences the last decades. Persistent organic pollutants have been indicated as potential carcinogenic compounds and it is therefore interesting to see if they can be a factor in the development of the disease. Here, we assessed the ...

Ulcerative Colitis (UC) is a chronic, inflammatory disease of the colon that has a relapsing-remitting characteristic. The disease management consists of prolonging periods of remission and reducing relapse frequency. There is currently no universally accepted definition of remission in UC. There are different methods of establishing if a patient is in remission, but the lack of definition and ...

Introduction: Carbonic anhydrase 6 (CA6) is the only secreted member of the carbonic anhydrase enzyme family. This enzyme catalyzes the reversible hydration of carbon dioxide: CO2 + H2O ⇔ H+ + HCO3-. The dehydration reaction contributes to net acidification in several tissues and biological fluids. Salivary CA6 attaches to the enamel and predisposes to caries probably by acidifying the dental biofilm ...

Declined fertility rate and population is a matter of serious concern, especially in the developed nations. Assisted Reproductive Technologies (ART), including in vitro fertilization (IVF), have provided great hope for infertility treatment and maintaining population growth and social structure. With the help of ART, more than 8 million babies have already been born so far. Despite the worldwide ...

<i>Purpose</i>: To assess whether acute myocardial infarction (MI) diagnoses in national health registers are sufficiently correct and complete to replace manual collection of endpoint data for a population-based, epidemiological study.<br><br> <i>Patients and Methods</i>: Using the Tromsø Study Cardiovascular Disease Register for 2013– 2014 as gold standard, we calculated correctness (defined ...

<i>Background/objective</i> - Having a 30-year follow-up of a cohort of women tested for HPV is a unique opportunity to further study long-term risk of CIN3+. The study objective was to compare HPV status at baseline with the risk of CIN3+ in the follow-up period of 30 years.<br><br> <i>Methods</i> - All women (n = 642) referred to the HPV outpatient clinic at the University Hospital of North ...

The adenosine A_2A receptor (A_2AR) represents a potential therapeutic target for neurodegenerative diseases. Aiming at the development of a positron emission tomography (PET) radiotracer to monitor changes of receptor density and/or occupancy during the A_2AR-tailored therapy, we designed a library of fluorinated analogs based on a recently published lead compound ...

The liver as the largest organ in the human body is composed of a complex macroscopic and microscopic architecture that supports its indispensable function to maintain physiological homeostasis. Optical imaging of the human liver is particularly challenging because of the need to cover length scales across 7 orders of magnitude (from the centimeter scale to the nanometer scale) in order to fully ...

Background: due to emerging therapeutics targeting KRAS G12C and previous reports with conflicting results regarding the prognostic impact of KRAS and KRAS G12C in non-small cell lung cancer (NSCLC), we aimed to investigate the frequency of KRAS mutations and their associations with clinical characteristics and outcome. Since mutation subtypes have different preferences for downstream pathways, we ...