Sexual behavior is innately motivated and rewarding. The underlying neurobiological mechanisms of sexual motivation, copulation, and sexual reward have not been completely unraveled. This thesis gives insight in the structure, organization, and neurobiological orchestration of male rat sexual behavior. The research presented in this thesis demonstrates that a more extensive behavioral annotation ...

Bakgrunn: Multippel sklerose er en kronisk demyeliniserende sykdom som man i dag ikke har en kurativ behandling for. Med moderne MS-behandling endres behandlingsmålene for pasienter. «No evidence of disease activity» - NEDA – betyr at pasienter ikke har tegn til sykdom ved funksjonsforverring, attakker eller nye lesjoner på MR over en viss tidsperiode. NEDA er foreslått som mål for behandling av ...

In Norway, all children are entitled to receive regular health checks. Child health centres for children 0–5 years old (CHC) provide these check-ups and are one of many health services that Norwegian municipalities have to offer. The aim of this study was to examine parents’ satisfaction with CHCs, and to identify predictors for the overall evaluation of the service. The sample comprised 1654 parents ...

Background - Prostate cancer tissues are inherently heterogeneous, which presents a challenge for metabolic profiling using traditional bulk analysis methods that produce an averaged profile. The aim of this study was therefore to spatially detect metabolites and lipids on prostate tissue sections by using mass spectrometry imaging (MSI), a method that facilitates molecular imaging of heterogeneous ...

BACKGROUND Oral Squamous Cell Carcinoma (OSCC) is the most common type of head and neck cancer and persists a leading cause of cancer associated mortality and morbidity universally. Survival rate is still poor at less than 50% urging the need for biomarkers to allow better diagnosis, prognosis and therapeutic strategies. In this study we focus on E2F4, a repressor of cell cycle, and further propose ...

Aim - To systematically review human metabolomic studies investigating metabolic responses in septic neonates.<p> <p>Methods - A systematic literature search was performed in the databases MEDLINE, EMBASE and Cochrane library up to the 1st of January 2021. We included studies that assessed neonatal sepsis and the following outcomes; (1) change in the metabolism compared to healthy neonates and/or ...

The assessment of sexual behavior in male rats with the aim of unraveling underlying neurobiological mechanisms has in the recent decades been reduced to the annotation of mounts, intromissions and ejaculations. To provide a better understanding of the structure and patterns of copulation, it is necessary to extend and tailor the analysis to the natural organization of male rat copulation. This will ...

Successful treatment of skin infections requires eradication of biofilms found in up to 90 % of all chronic wounds, causing delayed healing and increased morbidity. We hypothesized that chitosan hydrogel boosts the activity of liposomally-associated membrane active antimicrobials (MAA) and could potentially improve bacterial and biofilm eradication. Therefore, liposomes (∼300 nm) bearing chlorhexidine ...

Introduction: The incidence of pancreatic cancer is increasing worldwide and characterized by a particularly low survival rate. Studies have reported weak and inconsistent evidence for associations among reproductive factors, use of exogenous hormones, and pancreatic cancer incidence in women. <p> <p>Purpose: To investigate relationships between reproductive factors, exogenous hormones, and the ...

Objective - The aim of this integrative review was to identify facilitators and barriers to patients’ well-being when being cared for in an ICU setting, from the perspective of the patients.<p> <p>Background - To become critically ill and hospitalised in an ICU is a stressful, chaotic event due to the life-threatening condition itself, as well as therapeutic treatments and the environment. A ...