Det helsevitenskapelige fakultet: Nye registreringer

Viser treff 4021-4040 av 10619

    • Menstrual factors, reproductive history, hormone use, and urothelial carcinoma risk: A prospective study in the EPIC cohort 

      Lujan-Barroso, Leila; Botteri, Edoardo; Caini, Saverio; Ljungberg, Börje; Roswall, Nina; Tjønneland, Anne; Bueno-De-Mesquita, Bas; Gram, Inger Torhild; Tumino, Rosario; Kiemeney, Lambertus A.; Liedberg, Fredrik; Stocks, Tanja; Gunter, Marc; Murphy, Neil; Cervenka, Iris; Fournier, Agnès; Kvaskoff, Marina; Häggström, Christel; Overvad, Kim; Lund, Eiliv; Waaseth, Marit; Fortner, Renée T.; Kühn, Tilman; Menéndez, Virginia; Sánchez, María-José; Santiuste, Carmen; Perez-Cornago, Aurora; Zamora-Ros, Raul; Cross, Amanda J.; Trichopoulou, Antonia; Karakatsani, Anna; Peppa, Eleni; Palli, Domenico; Krogh, Vittorio; Sciannameo, Veronica; Mattiello, Amalia; Panico, Salvatore; van Gils, Carla H.; Onland-Moret, N. Charlotte; Barricarte, Aurelio; Amiano, Pilar; Khaw, Kay-Tee; Boeing, Heiner; Weiderpass, Elisabete; Duell, Eric J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-28)
      <p>Background: Urothelial carcinoma is the predominant (95%) bladder cancer subtype in industrialized nations. Animal and epidemiologic human studies suggest that hormonal factors may influence urothelial carcinoma risk. <p>Methods: We used an analytic cohort of 333,919 women from the European Prospective Investigation into Cancer and Nutrition Cohort. Associations between hormonal factors and ...

    • Stochastic Epigenetic Mutations Are Associated with Risk of Breast Cancer, Lung Cancer, and Mature B-cell Neoplasms 

      Gagliardi, Amedeo; Dugué, Pierre-Antoine; Nøst, Therese Haugdahl; Southey, Melissa C.; Buchanan, Daniel D.; Schmidt, Daniel F; Makalic, Enes; Hodge, Allison M; English, Dallas R.; Wong Doo, Nicole; Hopper, John L.; Severi, Gianluca; Baglietto, Laura; Naccarati, Alessio; Krogh, Vittorio; Palli, Domenico; Panico, Salvatore; Sacerdote, Carlotta; Tumino, Rosario; Lund, Eiliv; Giles, Graham; Pardini, Barbara; Sandanger, Torkjel M; Milne, Roger L.; Paolo, Vineis; Polidoro, Silvia; Fiorito, Giovanni (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-11)
      <p>Background: Age-related epigenetic dysregulations are associated with several diseases, including cancer. The number of stochastic epigenetic mutations (SEM) has been suggested as a biomarker of life-course accumulation of exposure-related DNA damage; however, the predictive role of SEMs in cancer has seldom been investigated. <p>Methods: A SEM, at a given CpG site, was defined as an extreme ...

    • Soluble Receptor for Advanced Glycation End-products (sRAGE) and colorectal cancer risk: a 1 case-control study nested within a European prospective cohort 

      Aglago, Elom K.; Rinaldi, Sabina; Freisling, Heinz; Jiao, Li; Hughes, David J.; Fedirko, Veronika; Schalkwijk, Casper C; Weiderpass, Elisabete; Dahm, Christina C.; Overvad, Kim; Eriksen, Anne Kirstine; Kyrø, Cecilie; Boutron-Ruault, Marie-Christine; Rothwell, Joseph A.; Severi, Gianluca; Katzke, Verena; Kuhn, Tilman; Schulze, Matthias B.; Krasimira, Aleksandrova; Masala, Giovanna; Krogh, Vittorio; Panico, Salavatore; Tumino, Rosario; Naccarati, Alessio; Bueno-De-Mesquita, Bas; van Gils, Carla H.; Sandanger, Torkjel M; Gram, Inger Torhild; Skeie, Guri; Quiros, J. Ramon; Jakszyn, Rachel; Sanchez, Maria-Jose; Amiano, Pilar; Huerta, Jose Maria; Ardanaz, Eva; Johansson, Ingegerd; Harlid, Sophia; Perez-Cornago, Aurora; Mayén, Ana-Lucia; Cordova, Reynalda; Gunter, Marc J.; Vineis, Paolo; Cross, Amanda J.; Riboli, Elio; Jenab, Mazda (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-20)
      <p>Background: Overexpression of the receptor for advanced glycation end-product (RAGE) has been associated with chronic inflammation, which in turn has been associated with increased colorectal cancer risk. Soluble RAGE (sRAGE) competes with RAGE to bind its ligands, thus potentially preventing RAGE-induced inflammation. <p>Methods: To investigate whether sRAGE and related genetic variants are ...

    • The development journey of an artificial intestinal model predicting oral drug absorption: the mucus-PVPA model 

      Falavigna, Margherita (Doctoral thesis; Doktorgradsavhandling, 2021-04-23)
      Oral drug administration is the most convenient route to systemically deliver drugs because of its cost-effectiveness, ease of administration and high patient compliance. However, when a drug is orally administered it will be exposed to the different physiological processes and environments found along the gastrointestinal (GI) tract, which will determine its ability of being absorbed and reach the ...

    • Predicting oral absorption of fenofibrate in lipid-based drug delivery systems by combining in vitro lipolysis with the mucus-PVPA permeability model 

      Falavigna, Margherita; Klitgaard, Mette; Berthelsen, Ragna; Mullertz, Anette; Flaten, Gøril Eide (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-08)
      The aim of this work was to develop a new in vitro lipolysis-permeation model to predict the in vivo absorption of fenofibrate in self-nanoemulsifying drug delivery systems (SNEDDSs). More specifically, the in vitro intestinal lipolysis model was combined with the mucus-PVPA (Phospholipid Vesicle-based Permeation Assay) in vitro permeability model. Biosimilar mucus (BM) was added to the surface of ...

    • We Ran a Hospital. The Norwegian Nurses efforts During the Korean War and the Impact of their Experiences on Norwegian Nursing and Theatre Nursing 

      Lockertsen, Jan-Thore (Doctoral thesis; Doktorgradsavhandling, 2021-04-23)
      <p>During the Korean War (1951-53), Norway operated and staffed a surgical field hospital at the front along the 38th parallel. The Norwegian Mobile Army Surgical Hospital – NORMASH – was a part of the United Nations peace-enforcing force to stop aggression from North-Korea towards South-Korea. <p>NORMASH was staffed only with civilian volunteers. Without any training as a military group or in war ...

    • Primary care use and cardiovascular disease risk in Russian 40–69 year olds: a cross-sectional study 

      Petersen, Jakob; Kontsevaya, Anna V.; McKee, Martin; Richardson, E.; Cook, Sarah Anne; Malyutina, Sofia; Kudryavtsev, Alexander V; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-04)
      <i>Background</i> - The Russian Federation has very high cardiovascular disease (CVD) mortality rates compared with countries of similar economic development. This cross-sectional study compares the characteristics of CVD-free participants with and without recent primary care contact to ascertain their CVD risk and health status.<br><br> <i>Methods</i> - A total of 2774 participants aged 40–69 ...

    • Utfordrende atferd hos personer med demens i forsterket enhet på sykehjem-sykepleieres erfaringer 

      Simonsen, Marianne; Helgesen, Ann Karin (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02)
      <p>Bakgrunn og hensikt: Utfordrende atferd er hyppig forekommende på sykehjem. Hensikten med studien er å få kunnskap om sykepleieres erfaringer med utfordrende atferd hos personer med demens i forsterket skjermet enhet på sykehjem. <p>Metode: Dette er en kvalitativ studie der data er samlet inn ved hjelp av fire semi-strukturerte forskningsintervju. Data er analysert ved å bruke systematisk ...

    • Examining the Incredible Years Teacher Classroom Management Program in a Regular Norwegian School Setting: Teacher-Reported Behavior Management Practice, Problem Behavior in Classroom and School Environment, Teacher Self- and Collective Efficacy, and Classroom Climate 

      Aasheim, Merete; Fossum, Sturla; Reedtz, Charlotte; Handegård, Bjørn Helge; Martinussen, Monica (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-29)
      In the present study, the Incredible Years Teacher Classroom Management (IY TCM) program was implemented as a universal preventive intervention in a regular, lower primary school setting. Outcomes for teacher’s behavior management practice, problem behavior in the classroom and the school environment, teacher self- and collective efficacy, and classroom climate were examined. Using a quasi-experimental ...

    • Trajectories of recall memory as predictive of hearing impairment: A longitudinal cohort study 

      Maharani, Asri; Dawes, Piers; Nazroo, James; Tampubolon, Gindo; Pendleton, Neil; Bertelsen, Geir; Cosh, Suzanne; Cougnard-Grégoire, Audrey; Delcourt, Cécile; Constantinidou, Fofi; Goedegebure, Andre; Helmer, Catherine; Arfan Ikram, M; Klaver, Caroline C.W.; Leroi, Iracema; Meester-Smor, Magda; Nae, Virginie; Oosterloo, Neelke; Schirmer, Henrik; Tiemeier, Henning; von Hanno, Therese (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-18)
      <i>Objectives</i> - Accumulating evidence points to a relationship between hearing function and cognitive ability in later life. However, the exact mechanisms of this relationship are still unclear. This study aimed to characterise latent cognitive trajectories in recall memory and identify their association with subsequent risk of hearing impairment.<p> <p><i>Methods</i> - We analysed data from ...

    • Adults’ dental treatment in 2001–2013 in Finnish public dental service 

      Lindén, J.; Widström, Eeva; Sinkkonen, Jari (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-21)
      <i>Background</i> - All adults over 17 years of age have access to the Public Dental Service after the Finnish Dental Care Reform in 2001–2002. This study aimed to survey the treatment needs and treatment measures provided for adult patients and changes in these during the period 2001–2013.<p> <p><i>Methods</i> - Sing each person’s unique identifier, demographic data on dental visits during the ...

    • Tn1 transposition in the course of natural transformation enables horizontal antibiotic resistance spread in Acinetobacter baylyi 

      Kloos, Julia Maria; Johnsen, Pål Jarle; Harms, Klaus (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-03)
      Transposons are genetic elements that change their intracellular genomic position by transposition and are spread horizontally between bacteria when located on plasmids. It was recently discovered that transposition from fully heterologous DNA also occurs in the course of natural transformation. Here, we characterize the molecular details and constraints of this process using the replicative transposon ...

    • Confirmatory analysis of QUARTZ study results: Survival prolongation after whole-brain radiotherapy 

      Nieder, Carsten; Dalhaug, Astrid; Pawinski, Adam (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-03)
      <p>Background/Aim: The aim of this study was to analyze the survival of patients with brain metastases treated with best supportive care or additional whole-brain radiotherapy (WBRT), in order to confirm results from the prospective randomized QUARTZ study, which suggested prolonged survival after WBRT (5 fractions of 4 Gy) if favorable prognostic factors were present (age younger than 60 years, ...

    • The interplay between executive control, behavioral variability and mind wandering: Insights from a high-definition transcranial direct-current stimulation study 

      Boayue, Nya Mehnwolo; Csifcsak, Gabor; Kreis, Isabel Viola; Schmidt, Carole; Finn, Iselin Caroline; Vollsund, Anna Elfrida Hovde; Mittner, Matthias (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-21)
      While the involvement of executive processes in mind wandering is largely undebated, their exact relationship is subject to an ongoing debate and rarely studied dynamically within‐subject. Several brain‐stimulation studies using transcranial direct current stimulation (tDCS) have attempted to modulate mind‐wandering propensity by stimulating the left dorsolateral prefrontal cortex (DLPFC) which is ...

    • The meaning of dignity for older adults: A meta-synthesis 

      Clancy, Anne; Simonsen, Nina; Lind, Johanne; Liveng, Anne; Johannessen, Aud (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-02)
      Dignified care is a central issue in the nursing care of older adults. Nurses are expected to treat older adults with dignity, and older adults wish to be treated in a dignified manner. Researchers have recommended investigating the concept of dignity based on specific contexts and population groups. This meta-synthesis study aims to explore the understandings of dignity from the perspective of older ...

    • Symptom burden in patients with reduced performance status at the start of palliative radiotherapy 

      Nieder, Carsten; Kämpe, Thomas A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-28)
      <p>Background/Aim: Previous research has suggested that palliative radiotherapy is a useful measure, unless short survival reduces the time spent without active treatment, and in the case of a low likelihood of experiencing a net benefit in quality of life. Patients with reduced performance status (PS) may be especially at risk of futile treatment, despite having a relatively high symptom burden and ...

    • Kidney tertiary lymphoid structures in Lupus Nephritis develop into large interconnected networks and resemble lymph nodes in gene signature 

      Dorraji, Seyed Esmaeil; Kanapathippillai, Premasany; Hovd, Aud-Malin Karlsson; Stenersrød, Mikael Ryan; Horvei, Kjersti Daae; Ursvik, anita; Figenschau, Stine; Thiyagarajan, Dhivya Borra; Fenton, Christopher Graham; Pedersen, Hege Lynum; Fenton, Kristin Andreassen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-16)
      Immune aggregates organized as tertiary lymphoid structures (TLS) are observed within the kidneys of patients with systemic lupus erythematosus and lupus nephritis (LN). Renal TLS was characterized in lupus-prone New Zealand black × New Zealand white F1 mice analyzing cell composition and vessel formation. RNA sequencing was performed on transcriptomes isolated from lymph nodes, macrodissected TLS ...

    • A metabolomic study of red and processed meat intake and acylcarnitine concentrations in human urine and blood 

      Wedekind, Roland; Kiss, Agneta; Keski-Rahkonen, Pekka; Viallon, Vivian; Rothwell, Joseph A; Cross, Amanda J.; Rostgaard-Hansen, Agnetha Linn; Sandanger, Torkjel M; Jakszyn, Paula; Schmidt, Julie A; Pala, Valeria; Vermeulen, Roel; Schulze, Matthias B; Kühn, Tilman; Johnson, Theron; Trichopoulou, Antonia; Peppa, Eleni; La Vechia, Carlo; Masala, Giovanna; Tumino, Rosario; Sacerdote, Carlotta; Wittenbecher, Clemens; de Magistris, Maria Santucci; Dahm, Christina C; Severi, Gianluca; Romana Mancini, Francesca; Vainio, Elisabete Weiderpass; Gunter, Marc J.R.; Huybrechts, Inge; Scalbert, Augustin (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-03)
      <p>Background - Acylcarnitines (ACs) play a major role in fatty acid metabolism and are potential markers of metabolic dysfunction with higher blood concentrations reported in obese and diabetic individuals. Diet, and in particular red and processed meat intake, has been shown to influence AC concentrations but data on the effect of meat consumption on AC concentrations is limited. <p>Objectives - ...

    • Blood polyphenol concentrations and differentiated thyroid carcinoma in women from the European Prospective Investigation into Cancer and Nutrition (EPIC) study 

      Zamora-Ros, Raul; Lujan-Barroso, Leila; Achaintre, David; Franceschi, Silvia; Kyrø, Cecilie; Overvad, Kim; Tjønneland, Anne; Truong, Therese; Lecuyer, Lucie; Boutron-Ruault, Marie Christine; Katzke, Verena; Johnson, Theron S.; Schulze, Matthias B; Trichopoulou, Antonia; Peppa, Eleni; La Vechia, Carlo; Masala, Giovanna; Pala, Valeria; Panico, Salvatore; Tumino, Rosario; Ricceri, Fulvio; Skeie, Guri; Ramón Quirós, J; Rodriguez-Barranco, Miguel; Amiano, Pilar; Chirlaque, María Dolores; Ardanaz, Eva; Almquist, Martin; Hennings, Joakim; Vermeulen, Roel; Wareham, Nicholas J; Tong, Tammy Y.N.; Aune, Dagfinn; Byrnes, Graham; Weiderpass, Elisabete; Scalbert, Augustin; Rinaldi, Sabina; Agudo, Antonio (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-06)
      <p>Background - Polyphenols are natural compounds with anticarcinogenic properties in cellular and animal models, but epidemiological evidence determining the associations of these compounds with thyroid cancer (TC) is lacking. <p>Objectives - The aim of this study was to evaluate the relations between blood concentrations of 36 polyphenols and TC risk in EPIC (the European Prospective Investigation ...

    • Medisinsk tannturisme: Kan behandling utenfor Norden medføre økt risiko for bærerskap og infeksjoner av antibiotika resistente bakterier? 

      Olsvik, Ørjan; Lilleng, Urd; Lund, Bodil Kristina (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-03)
      I de senere år har antibiotikaresistente bakterier blitt et økende medisinsk problem. Slike bakterier har smittet medisinske turister, og blitt bragt hjem til Norden. Det er beregnet at det i verden er nærmere 20 millioner pasienter som reiser internasjonalt, og at kostnadene er over 50 milliarder US dollar. I Europa er det pasienter som ønsker billig tannbehandling som utgjør hovedmengden av ...