<p><i>Introduction - </i>The aims of this thesis were (1) to describe the characteristics of women with chronic pelvic pain (CPP) referred for physical therapy after evaluation at a tertiary hospital, (2) to compare group-based multimodal physical therapy (intervention group) with primary care physical therapy (comparator group), and (3) to explore if selected pre-treatment characteristics were ...

Bakgrunn: Rehabilitering er en sentral del av fysioterapitjenesten. Innføring av flere nasjonale handlingsplaner, der digitalisering står i fokus, kan tyde på at tradisjonell rehabilitering vil måtte endres og tilpasses. Telerehabilitering er en tilnærming som hevdes å kunne øke tilgjengelighet. Hensikten med denne studien var å undersøke pasienters erfaring med fysioterapi over avstand. Metode: ...

Cells subjected to environmental stresses undergo regulated cell death (RCD) when homeostatic programs fail to maintain viability. A major mechanism of RCD is the excessive calcium loading of mitochondria and consequent triggering of the mitochondrial permeability transition (mPT), which is especially important in post‐mitotic cells such as cardiomyocytes and neurons. Here, we show that stress‐induced ...

Deliberation is commonly assumed to be a central characteristic of humans’ higher cognitive functions, and the responses following deliberation are attributed to mechanisms that are qualitatively different from lower-level associative or affectively driven responses. In contrast to this perspective, the current article’s aim is to draw attention to potential issues with making inferences about ...

The TNM classification is well established as a state-of-the-art prognostic and treatment-decision-making tool for non-small cell lung cancer (NSCLC) patients. However, incorporation of biological data may hone the TNM system. This article focuses on choosing and incorporating subsets of tissue-infiltrating lymphocyte (TIL), detected by specific immunohistochemistry and automatically quantified by ...

Age-related changes in the liver sinusoidal endothelium, particularly the reduction in fenestrations, contribute to insulin resistance in old age. Metformin impacts on the aging process and improves insulin resistance. Therefore, the effects of metformin on the liver sinusoidal endothelium were studied. Metformin increased fenestrations in liver sinusoidal endothelial cells isolated from both young ...

Brukermedvirkning er et ideal for norske myndigheter og helsevesen, og en rettighet for personer som benytter seg av tjenester, også innen psykisk helsevern. Et relevant spørsmål er om brukermedvirkning representerer en majoritetsforståelse for brukerorienterte tjenestetilbud, og om en slik forståelse direkte kan overføres til arbeid med samisk befolkning. Hensikten med vår studie er å få økt ...

<i>Background</i> - GPs use their judgement on whether to participate in emergencies; however, little is known about how GPs make their decisions on emergency participation.<p> <p><i>Aim</i> - To test whether GPs' participation in emergencies is associated with cause of symptoms, distance to the patient, other patients waiting, and out-of-hours (OOH) clinic characteristics.<p> <p><i>Design & ...

<p><i>Background - </i>The antitumor efficacy of PARP inhibitors (PARPi) for breast cancer patients harboring germline BRCA1/2 (gBRCA1/2) mutations is well established. While PARPi monotherapy was ineffective in patients with metastatic triple negative breast cancer (TNBC) wild type for BRCA1/2, we hypothesized that PARPi may be effective in primary TNBCs without previous chemotherapy exposure. < ...

<p><i>Background - </i>Surgery on extraforaminal lumbar disc herniation (ELDH) is a commonly performed procedure. Operating on this type of herniation is known to come with more difficulties than on the frequently seen paramedian lumbar disc herniation (PLDH). However, no comparative data are available on the effectiveness and safety of this operation. We sought out to compare clinical outcomes at ...