Anti-HPA-1a-antibodies are the main cause of fetal and neonatal alloimmune thrombocytopenia (FNAIT) which may result in intracranial hemorrhage (ICH) and death among fetuses and newborns. Advances in understanding the pathogenesis of FNAIT and proof of concept for prophylaxis to prevent immunization suggest that development of hyperimmune anti-HPA-1a IgG aimed at preventing immunization against ...

This study examined the robustness of a traditional memory task when moved out of controlled traditional settings. A letter recall task was designed to be self-administered via a smart-device which assessed recall by participants’ writing their responses on the device. This enabled collection of both the letter recalled and the timing of this recall such that the temporal dynamics could be examined. ...

<i>Objective</i> - To determine the prevalence of orofacial symptoms, dysfunctions, and deformities of the temporomandibular joint (TMJ) in juvenile idiopathic arthritis (JIA) 17 years after disease onset.<p> <p><i>Methods</i> - Drawn from a prospective, population-based Nordic JIA cohort with disease onset from 1997 to 2000, 420 consecutive cases were eligible for orofacial evaluation of TMJ ...

<p>Background: The excessive and unwarranted consumption of antibiotics is the leading factor in promoting the spread of antimicrobial resistant (AMR), which is considered to be a potential major threat to global public health and economic growth. Several systematic reviews have been published exploring the pattern of antibiotic use in the Middle East and low-and middle-income countries without ...

<i>Objective</i> - Exposure to a cold environment at work is associated with a higher prevalence of musculoskeletal pain and chronic pain in cross-sectional studies. This study aims to determine the association between working in a cold environment ≥ 25% of the time and musculoskeletal complaints (MSC) 7–8 years later.<p> <p><i>Methods</i> - We followed participants from the sixth survey (Tromsø ...

<i>Background:</i> Subjective cognitive decline (SCD) is associated with an increased risk of Alzheimer’s disease (AD). However, patients reporting SCD to their general practitioner are not always referred to a memory clinic.<p> <p><i>Objective:</i> To investigate whether prior history of medical help-seeking is associated with AD biomarker abnormality, worse cognitive performance, and/or depressive ...

<i>Background</i> - People with intellectual disabilities (ID) have lower levels of physical activity than the general population. The aim of this study was to understand the motivational factors of participation in physical activity for people with ID from the perspectives of the family members and staff.<p> <p><i>Method</i> - An abductive qualitative design was used. Social Cognitive Theory ...

<i>Aim/Objective</i>: Ulcerative colitis (UC) is a chronic inflammatory bowel disease. In UC, a wide range of criteria are used for disease remission, with few studies investigating the differences between disease remission and normal control groups. This paper compares known inflammatory and healing mediators in the mucosa of UC in clinical remission and normal controls, in order to better describe ...

<i>Objective</i> - Reduction in cerebral volume is often found in underweight patients with anorexia nervosa (AN), but few studies have investigated other morphological measures. Cortical thickness (CTh) and surface area (CSA), often used to produce the measure of cortical volume, are developmentally distinct measures that may be differentially affected in AN, particularly in the developing brain. ...

We report the synthesis, radiosynthesis and biological characterisation of two gonadotropin‐releasing hormone receptor (GnRH−R) antagonists with nanomolar binding affinity. A small library of GnRH−R antagonists was synthesised in 20–67 % overall yield with the aim of identifying a high‐affinity antagonist capable of crossing the blood–brain barrier. Binding affinity to rat GnRH−R was determined by ...