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norskDet helsevitenskapelige fakultet: Nye registreringer
Viser treff 4541-4560 av 10625
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Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-12)<p><i>BACKGROUND: </i> The UN's Sustainable Development Goals (SDGs) are grounded in the global ambition of "leaving no one behind". Understanding today's gains and gaps for the health-related SDGs is essential for decision makers as they aim to improve the health of populations. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016), we measured 37 of the 50 ... -
Does Religion Matter? Italians' Responses towards Muslim and Christian Arab Immigrants as a function of their Acculturation Preferences
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-12)A 2 × 2 × 2 experiment examined the role of immigrants’ religion and perceived acculturation strategy on majority members’ attitudes. Acculturation strategies were manipulated along the two dimensions of contact and culture maintenance. Italian majority members (N = 247) read fictitious but seemingly real interviews with Arab immigrants, in which the immigrants’ religion (Muslim vs. Christian) and ... -
Stroma-induced phenotypic plasticity offers phenotype-specific targeting to improve melanoma treatment
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-18)Cancer cells' phenotypic plasticity, promoted by stromal cells, contributes to intra-tumoral heterogeneity and affects response to therapy. We have disclosed an association between fibroblast-stimulated phenotype switching and resistance to the clinically used BRAF inhibitor (BRAFi) vemurafenib in malignant melanoma, revealing a challenge in targeting the fibroblast-induced phenotype. Here we compared ... -
Role of Oestrogen α Receptors in Sociosexual Behaviour in Female Rats Housed in a Seminatural Environment
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-28)The present study investigated the role of oestrogen receptor (ER)α in the ventromedial nucleus of the hypothalamus (VMN), the preoptic area (POA), the medial amygdala (MePD) and the bed nucleus of stria terminalis (BNST) in sociosexual behaviour in female rats. This was conducted in two sets of experiments, with the VMN and POA investigated in the first set, and the MePD and BNST in the second set. ... -
Physical exercise and chronic pain in university students
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-26)<i>Background</i> - Physical inactivity and chronic pain are both major public health concerns worldwide. Although the health benefits of regular physical exercise are well-documented, few large epidemiological studies have investigated the association between specific domains of physical exercise and chronic pain in young adults. We sought to investigate the association between frequency, intensity ... -
Molecularly matched therapy in the context of sensitivity, resistance, and safety; patient outcomes in end-stage cancer - the MetAction study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-25)<i>Background</i>: In precision cancer medicine, the challenge is to prioritize DNA driver events, account for resistance markers, and procure sufficient information for treatment that maintains patient safety. The MetAction project, exploring how tumor molecular vulnerabilities predict therapy response, first established the required workflow for DNA sequencing and data interpretation (2014–2015). ... -
Har jordmødre og helsesøstre i Nord-Norge nødvendig kunnskap om det essensielle sporstoffet jod og om jodstatus blant gravide og ammende kvinner? MISA 2-undersøkelsen 2017–2018
(Master thesis; Mastergradsoppgave, 2018-06-27)Sammendrag Bakgrunn: Mild til moderat jodmangel er påvist hos gravide og ammende kvinner i Norge, noe som kan påvirke hjerneutviklingen til fosteret og redusere barnets IQ. Jordmødre og helsesøstre har en sentral rolle i veiledning av utsatte grupper knyttet til svangerskap og ammeperiode. Denne studien evaluerer i hvilken grad jordmødre og helsesøstre i Nord-Norge har nødvendig kunnskap om jod ... -
Serum lactate dehydrogenase contributes to prognostic assessment in patients with oligometastatic cancer and brain involvement
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01)<p><i>Background/Aim - </i>The aim of this study was to analyze the prognostic impact of serum lactate dehydrogenase (LDH) in patients with oligometastatic brain metastases, arbitrarily defined as max. Four brain lesions and 5 metastatic lesions overall. <p><i>Patients and Methods - </i>This was a retrospective single institution analysis. Overall, 42 patients were identified from a prospectively ... -
Norwegian constraint-induced therapy multisite trial: Adherence to treatment protocol applied early after stroke
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-24)<p><i>OBJECTIVE: </i>To investigate to what degree patients adhered to a modified constraint-induced movement therapy protocol, and to explore factors associated with the results. <p><i>DESIGN: </i>Prospective follow-up of the intervention arm in a randomized controlled trial. <p><i>SUBJECTS: </i>Twenty-four patients within 28 days after stroke. <p><i>METHODS: </i>The protocol specified 180 min ... -
Adverse events as a measure of patient safety in cancer care
(Doctoral thesis; Doktorgradsavhandling, 2020-09-11)“First, do no harm” is a fundamental element of health care and considered indistinguishable from the delivery of quality in health care. While cancer care has become more effective, it has also become more complex consequently increasing the risk for harm. We have assessed the extent and severity of treatment related adverse events in hospitalised cancer patients and elucidated how adverse events ... -
Parent Satisfaction with the Open kindergarten in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-17)Open kindergartens are a low-threshold pedagogical service that preschool-aged children, accompanied by an adult caregiver, can attend without appointment or registration. The aims of this study were to examine users’ experiences with the open kindergarten in Norway and to identify predictors for the overall satisfaction with the service. User satisfaction surveys were conducted over a 6-8-week ... -
Newborn Behavioral Observation, maternal stress, depressive symptoms and the mother-infant relationship: results from the Northern Babies Longitudinal Study (NorBaby)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-15)<i>Background</i> - Families can experience the postpartum period as overwhelming and many report a special need for support. The Newborn Behavioral Observation (NBO) aims to promote a positive parent-infant relationship by sensitising parents to the infant’s signals. This article evaluates the NBO as a universal preventive intervention within the regular well-baby clinic service on measures of ... -
Impact and Challenges of M-health Application. A Study in Rural Nepal.
(Master thesis; Mastergradsoppgave, 2020-05-15)Background: Telemedicine is the use of information and communication technologies to provide healthcare services when the participants- the healthcare professional and patients are in different locations. It does not denote a separate medical method, rather it represents the tools that can be applied by health professionals to extend their services to the people living in distance. The present study ... -
Co-creating since 1990s: an qualitative analyses of the exploratory case study on a small private health IT company in North Norway though the prism of ANT.
(Master thesis; Mastergradsoppgave, 2020-05-14)Digitalization of healthcare is done through development and delivery of health information technology, mobile health, wearable devices, telehealth, telemedicine, health portals, personalized medicine, or in other words – ehealth. Ehealth solutions are expected to improve the treatment process, improved safety, efficiency and quality, as well as empowerment of both patients and healthcare professionals. ... -
Randomised comparison of provisional side branch stenting versus a two-stent strategy for treatment of true coronary bifurcation lesions involving a large side branch: The Nordic-Baltic Bifurcation Study IV
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-19)<p><i>Background - </i>It is still uncertain whether coronary bifurcations with lesions involving a large side branch (SB) should be treated by stenting the main vessel and provisional stenting of the SB (simple) or by routine two-stent techniques (complex). We aimed to compare clinical outcome after treatment of lesions in large bifurcations by simple or complex stent implantation. <p><i>Methods ... -
ZN148 Is a Modular Synthetic Metallo-beta-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-21)Carbapenem-resistant Gram-negative pathogens are a critical public health threat and there is an urgent need for new treatments. Carbapenemases (β-lactamases able to inactivate carbapenems) have been identified in both serine β-lactamase (SBL) and metallo-β-lactamase (MBL) families. The recent introduction of SBL carbapenemase inhibitors has provided alternative therapeutic options. Unfortunately, ... -
Is there a seasonal variation of survival after systemic chemotherapy for metastatic castration-resistant prostate cancer in a rural part of North Norway?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-19)The winter darkness or polar night induces endocrine and metabolic mechanisms, which might reduce the efficacy of cancer treatment and thus contribute to shorter survival. Moreover, season-and weather-related treatment delays and irregularities might also cause reduced efficacy of anti-cancer drugs. Therefore, this study evaluated the prognostic impact of timing of chemotherapy (start during winter ... -
Lifetime ultraviolet radiation exposure and DNA methylation in blood leukocytes: The Norwegian Women and Cancer Study
(Journal article; Tidsskriftartikkel, 2020-03-11)Ultraviolet radiation (UVR) exposure is a leading cause of skin cancers and an ubiquitous environmental exposure. However, the molecular mechanisms relating UVR exposure to melanoma is not fully understood. We aimed to investigate if lifetime UVR exposure could be robustly associated to DNA methylation (DNAm). We assessed DNAm in whole blood in three data sets (n = 183, 191, and 125) from the Norwegian ... -
PALLiON - PALLiative care Integrated in ONcology: Study protocol for a Norwegian national cluster-randomized control trial with a complex intervention of early integration of palliative care
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-02)<p><i>Background - </i>Several publications have addressed the need for a systematic integration of oncological care focused on the tumor and palliative care (PC) focused on the patient with cancer. The exponential increase in anticancer treatments and the high number of patients living longer with advanced disease have accentuated this. Internationally, there is now a persuasive argument that ... -
Epidemiological and molecular characterization of Streptococcus pneumoniae carriage strains in pre-school children in Arkhangelsk, northern European Russia, prior to the introduction of conjugate pneumococcal vaccines
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-15)<p><i>Background - </i>The 13-valent Pneumococcal Conjugate Vaccine (PCV-13) was introduced in the National Immunization Programme (NIP) schedule in Russia in March 2014. Previously, the 7-valent Pneumococcal Conjugate Vaccine (PCV-7) was marketed in Russia in 2009 but has never been offered for mass vaccination. A carriage study was performed among children in Arkhangelsk in 2006. The objective was ...
