When bacteria are exposed to antibiotics, the rate of killing can slow down dramatically over time. This phenomenon can be observed both in vitro and in vivo. In vitro, the mechanistic explanations for this can be divided into two main categories: antibiotic persistence and heteroresistance. In vivo, both mechanisms thought to contribute to observed slowdowns in the elimination and as a result may ...

<i>Objectives</i> - To evaluate critical care nurses’ experiences of ICU diaries following the implementation of national recommendations for the use of diaries for critically ill patients.<p><p> <i>Design</i> - A quality improvement project describing the development and implementation of national recommendations (2011), as well as the assessment of the use of diaries in intensive care nursing ...

Background: Mass spectrometry-based proteomics has increasingly been the choice of method for the global analysis of the composition, modification and dynamics of proteins. Quantitative analysis of the proteome with tandem mass tag is a technique for calculating the relative abundance of the proteome in tissues and organelles. In this thesis, present a novel bottom-up method for the quantitative ...

Neuroblastoma is the most common diagnosed tumor in infants and the second most common extracranial tumor of childhood. The survival rate of patients with high-risk neuroblastoma is still very low despite intensive multimodal treatments. Therefore, new treatment strategies are needed. In recent years, miRNA-based anticancer therapy has received growing attention. Advances in this novel treatment ...

Abnormal increases in nucleolar size and number caused by dysregulation of ribosome biogenesis has emerged as a hallmark in the majority of spontaneous cancers. The observed ribosome hyperactivity can be directly induced by the MYC transcription factors controlling the expression of RNA and protein components of the ribosome. Neuroblastoma, a highly malignant childhood tumor of the sympathetic nervous ...

The elderly population is rapidly growing, and elderly individuals are more vulnerable to nutritional problems than other adults. A number of studies have found evidence for adverse health outcomes in elderly patients at risk of malnutrition. However, much of the previous research has been performed in hospital populations or in groups of elderly patients with specific diagnoses. More population-based ...

Prefaktiske tanker – tanker om konsekvenser av tenkte handlinger før de utføres – kan være gunstig for å forstå hvordan fremtidige mål kan oppnås. (Epstude, Scholl & Roese, 2016), mens kontrafaktisk tanker – tanker om hva som alternativt kunne skjedd – er funksjonell ved å hjelpe individet med atferdsregulering (Epstude & Roese, 2008). Denne studien undersøker sammenhengen mellom studenters prefaktiske- ...

The human PRKAR1A gene is a 381- amino acid protein encoding the regulatory subunit (RIα) of the cAMP dependent Protein Kinase A (PKA). The main function of PRKAR1A is to regulate the catalytic activity of PKA. PRKAR1A is shown to regulate autophagy via association with mTOR kinase and colocalization with the autophagy marker proteins LC3B, Rab7 and Rab9. Contradictory findings regarding the ...

Nonsevere obstructive sleep apnea (OSA) is most often treated with a continuous positive airway pressure (CPAP) device or a mandibular advancement splint (MAS). However, patient compliance with these treatments is difficult to predict. Improvement in apnea-hypopnea index (AHI) is also somewhat unpredictable in MAS treatment. In this study, we investigated the association between Friedman tongue ...

Forskning på kroppsøvingsfaget i Norge tyder på at noen elever ikke liker faget og at faget preges av gamle tradisjoner og diskurser. I egen kroppsøvingsundervisning tror jeg manglende verbal involvering hos elevene er en av barriere for læring, utvikling og interesse for faget. Jeg hadde derfor et ønske om å utvikle undervisningen og en tanke om at samarbeidslæring som evidensbasert undervisning, ...