Det helsevitenskapelige fakultet: Nye registreringer
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Multimodal classification of molecular subtypes in pediatric acute lymphoblastic leukemia
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-08)Genomic analyses have redefined the molecular subgrouping of pediatric acute lymphoblastic leukemia (ALL). Molecular subgroups guide risk-stratification and targeted therapies, but outcomes of recently identified subtypes are often unclear, owing to limited cases with comprehensive profiling and cross-protocol studies. We developed a machine learning tool (ALLIUM) for the molecular subclassification ... -
Storytelling in Focus Group Discussions: A Narrative Approach to Phenomena With Temporal Dimensions in Medical Education Research
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-09)People can express experiences, opinions, and perspectives in stories. In a story, the experiences can be relived and discovered independently of time and place. In medical education, it is a fundamental premise that time progresses, and it is within this temporal space that students learn, acquire competencies, and form identity. It is also within this space that much qualitative research is ... -
pH-dependent structural transitions in cationic ionizable lipid mesophases are critical for lipid nanoparticle function
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-06)Lipid nanoparticles (LNPs) are advanced core-shell particles for messenger RNA (mRNA) based therapies that are made of polyethylene glycol (PEG) lipid, distearoylphosphatidylcholine (DSPC), cationic ionizable lipid (CIL), cholesterol (chol), and mRNA. Yet the mechanism of pH-dependent response that is believed to cause endosomal release of LNPs is not well understood. Here, we show that eGFP (enhanced ... -
Energetics, energy availability and Relative Energy Deficiency in Sport (REDs) in female football players - Methodological perspectives and research implications
(Doctoral thesis; Doktorgradsavhandling, 2024-01-18)<p><i>Background:</i> For athletes, it is imperative that energy intake adequately addresses the total energy requirements inherent to their specific sport. Low energy availability, which is the failure to provide the body with adequate energy to sustain physiological homeostasis, may potentially result in Relative Energy Deficiency in Sport (REDs). This is a syndrome that can have detrimental health ... -
Smertelindring i forbindelse med suturering av fødselsrift
(Mastergradsoppgave; Master thesis, 2023-03-14)Hensikt: Studien søker å få økt innsikt i hvilke erfaringer norske jordmødre har til lindring av kvinners smerter og ubehag i forbindelse med suturering av fødselsrifter. Problemstilling: Jordmors erfaringer med lindring av kvinnens smerter og ubehag i forbindelse med suturering av fødselsrift. Metode: Kvalitativt forskningsdesign med semistrukturerte individualintervju med åtte jordmødre i ... -
Induksjon og informert samtykke - En kvalitativ studie om jordmødres opplevelser med induksjon og informert samtykke i sammenheng med fødsel.
(Mastergradsoppgave; Master thesis, 2023-03-13)Tittel: «Induksjon og informert samtykke» - En kvalitativ studie om jordmødres opplevelser med induksjon og informert samtykke i sammenheng med fødsel. Hensikt: Å få en større forståelse og innsikt i jordmødres opplevelser med induksjon og informert samtykke i sammenheng med fødsel. Problemstilling: Hvilke opplevelser har jordmødre med induksjon og informert samtykke i sammenheng med fødsel? ... -
Nyutdannede jordmødre og traumatiske hendelser - En kvalitativ studie om nyutdannede jordmødres opplevelser av traumatiske hendelser i fødsel, og hvordan erfaringene påvirker deres yrkespraksis
(Mastergradsoppgave; Master thesis, 2023-03-13)Tittel: “Nyutdannede jordmødre og traumatiske hendelser” - En kvalitativ studie om nyutdannede jordmødres opplevelser av traumatiske hendelser i fødsel, og hvordan erfaringene påvirker deres yrkespraksis. Hensikt: Å undersøke hvordan nyutdannede opplever traumatiske hendelser tidlig i karrieren, og hvordan erfaringene eventuelt påvirker deres yrkespraksis videre. Problemstilling: Nyutdannede ... -
Identification of a regulatory pathway governing TRAF1 via an arthritis-associated non-coding variant
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-16)TRAF1/C5 was among the first loci shown to confer risk for inflammatory arthritis in the absence of an associated coding variant, but its genetic mechanism remains undefined. Using Immunochip data from 3,939 patients with juvenile idiopathic arthritis (JIA) and 14,412 control individuals, we identified 132 plausible common non-coding variants, reduced serially by single-nucleotide polymorphism ... -
“Balancing two worlds”: a constructivist grounded theory exploring distributed/decentralised nursing education in rural and remote areas in Canada and Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-21)A challenge confronting northern nursing is delivery of equitable and culturally competent nursing education. Advances in technology support distributed approaches for decentralised learning and enhance the feasibility of nursing education in rural and remote regions. However, there is limited scholarship on distributed/decentralised technologies in nursing education, particularly in northern and ... -
Global research trends of sham acupuncture: A bibliometric analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-30)Objective - Sham acupuncture has been used as a control in acupuncture efficacy trials. However, questions have been raised about whether it is a physiologically inert placebo. We aimed to understand global research trends and provide guidance for future research by conducting a bibliometric analysis of sham acupuncture studies.<p> <p>Methods - Journal articles published to date related to sham ... -
Impact of the COVID-19 pandemic on breast cancer incidence and tumor stage in the Netherlands and Norway: A population-based study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-27)Background - Comparing the impact of the COVID-19 pandemic on the incidence of newly diagnosed breast tumors and their tumor stage between the Netherlands and Norway will help us understand the effect of differences in governmental and social reactions towards the pandemic.<p< <p>Methods - Women newly diagnosed with breast cancer in 2017–2021 were selected from the Netherlands Cancer Registry and ... -
Unpacking the Public Health Triad of Social Inequality in Health, Health Literacy, and Quality of Life—A Scoping Review of Research Characteristics
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-27)Social inequalities in health, health literacy, and quality of life serve as distinct public health indicators, but it remains unclear how and to what extent they are applied and combined in the literature. Thus, the characteristics of the research have yet to be established, and we aim to identify and describe the characteristics of research that intersects social inequality in health, health ... -
Population structure and antimicrobial resistance among Klebsiella isolates sampled from human, animal, and environmental sources in Ghana: a cross-sectional genomic One Health study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-16)Background One Health approaches to address the increasing threat of antimicrobial resistance (AMR) are gaining attention. However, data on the distribution and movement of bacteria and their AMR-associated genes between clinical and non-clinical sources are scarce, especially from low-income and middle-income countries. We aimed to analyse Klebsiella isolates from various sources in Ghana and ... -
In need of percutaneous coronary intervention in an arctic setting– patients’ experience of safety and quality of care: a qualitative study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-29)Patients with coronary heart disease need timely treatment for survival and optimum prognosis. There is limited research exploring patients’ experience regarding distance to percutaneous coronary intervention. The aim was to explore patients’ experiences of aspects contributing to safety and quality of care regarding health services following percutaneous coronary intervention in Northern Norway. A ... -
Dental professionals’ views on motivational interviewing for the prevention of dental caries with adolescents in central Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-20)Background - Establishing positive oral health behaviours during adolescence should be a key priority to improve lifelong oral health. However, changing adolescent behaviours is known to be a challenge. Motivational interviewing (MI) is a method of working with patients to activate their motivation for change and has shown promising results within the dental setting. Yet, little is known about the ... -
General practitioners’ role in safeguarding patients with dementia in their use of dietary supplements. A qualitative study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-20)Objective - The use of dietary supplements (DS) may cause harm through direct and indirect effects. Patients with dementia may be particularly vulnerable. This study aims to explore general practitioners’ (GPs’) experiences with DS use by these patients, the GPs perceived responsibilities, obstacles in taking on this responsibility, their attitudes toward DS, and suggestions for improvements to ... -
The Computed Sinusoid
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-11)Hepatic sinusoids are lined with thin endothelial cells with transcellular pores, termed fenestrations. These fenestrations are open channels that connect the sinusoidal lumen to the underlying Space of Disse (SoD) and the hepatocytes of the liver parenchyma. Fenestrations range from 0.05 to 0.35 µm in diameter and cover 5–15% of the sinusoidal endothelial surface area, depending on their location ... -
Enterococcal Membrane Vesicles as Vaccine Candidates
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-07)Enterococcus faecium is a leading cause of nosocomial infections, particularly in immunocompromised patients. The rise of multidrug-resistant E. faecium, including Vancomycin-Resistant Enterococci (VRE), is a major concern. Vaccines are promising alternatives to antibiotics, but there is currently no vaccine available against enterococci. In a previous study, we identified six protein vaccine ... -
Exploring mitochondrial quality control mechanisms and mitochondria-lipid droplet interactions in cardiac cell models
(Doctoral thesis; Doktorgradsavhandling, 2024-01-11)Mitochondria are the main energy producing units (organelles) in cardiac cells (cardiomyocytes). Cardiomyocytes have especially high mitochondrial content due to the heart’s continuous energy-intensive pumping. Studies of heart disease (such as heart failure) indicate that mitochondrial dysfunction is central to disease progression. There are many cellular mechanisms that protect mitochondria from ... -
Association of maternal SARS-CoV-2 infection at the time of admission for delivery with labor process and outcomes of vaginal birth: A cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-05)Introduction - This study aimed to investigate the impact of maternal SARS-CoV-2 infection at the time of admission for delivery on labor process and outcomes of vaginal birth.<p> <p>Material and methods - A cohort study was carried out at the Obstetrics Department of Anhui Provincial Hospital, China, where universal reverse transcriptase polymerase chain reaction (RT-PCR) testing for SARS-CoV-2 ...