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Regression-based normative data for the D-KEFS Color-Word Interference Test in Norwegian adults ages 20–85
(Journal article; Tidsskriftartikkel, 2023-11-16)<p><i>Objective:</i> The Delis-Kaplan Executive Function System (D-KEFS) Color-Word-Interference Test (CWIT; AKA Stroop test) is a widely used measure of processing speed and executive function. While test materials and instructions have been translated to Norwegian, only American age-adjusted norms from D-KEFS are available in Norway. We here develop norms in a sample of 1011 Norwegians between 20 ... -
Pharmaceutical Care Network Europe definition of quality indicators for pharmaceutical care: a systematic literature review and international consensus development
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-30)Background Over the past 40 years, the tasks of pharmacists have shifted from logistic services to pharmaceutical care (PhC). Despite the increasing importance of measuring quality of care, there is no general defnition of Quality Indicators (QIs) to measure PhC. Recognising this, a working group in a European association of PhC researchers, the Pharmaceutical Care Network Europe (PCNE), was ... -
Testing for the fitness benefits of natural transformation during community-embedded evolution
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-01)Natural transformation is a process where bacteria actively take up DNA from the environment and recombine it into their genome or reconvert it into extra-chromosomal genetic elements. The evolutionary benefits of transformation are still under debate. One main explanation is that foreign allele and gene uptake facilitates natural selection by increasing genetic variation, analogous to meiotic ... -
Involvement of A13 dopaminergic neurons in prehensile movements but not reward in the rat
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-09)Tyrosine hydroxylase (TH)-containing neurons of the dopamine (DA) cell group A13 are well positioned to impact known DA-related functions as their descending projections innervate target regions that regulate vigilance, sensory integration, and motor execution. Despite this connectivity, little is known regarding the functionality of A13-DA circuits. Using TH-specific loss-of-function methodology ... -
SLE classification criteria: Is “The causality principle” integrated and operative – and do the molecular and genetical network, on which criteria depend on, support the definition of SLE as “a one disease entity” – A theoretical discussion
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-24)Molecular and cellular aspects of the autoimmune pathophysiology in SLE is linked to the “The causality principle”. SLE Classification Criteria identify per definition disease measures (here: synonymous with classification criteria), but not diagnostic criteria within a classical framework. These two mostly theoretical criteria collections represent a salient conflict between phenomenology and the ... -
Oral health-related quality of life, impaired physical health and orofacial pain in children and adolescents with juvenile idiopathic arthritis – a prospective multicenter cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-20)Background - Knowledge on oral health-related quality of life (OHRQoL) in children and adolescents with juvenile idiopathic arthritis (JIA) is limited, and longitudinal studies are lacking. We aimed to describe OHRQoL in children and adolescents with JIA compared to controls, and to explore the validity and internal consistency of the Early Childhood Oral Health Impact Scale (ECOHIS) and the Child ... -
The Association Between Metabolic Syndrome, Hyperfiltration, and Long-Term GFR Decline in the General Population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-01)Introduction: One-quarter of adults worldwide meet the criteria of metabolic syndrome (MetS). MetS increases the risk of diabetes, chronic kidney disease (CKD), and cardiovascular disease. However, the association between MetS, hyperfiltration, and long-term glomerular filtration rate (GFR) decline in the general population is unknown.<p> <p>Methods: In the Renal Iohexol Clearance Survey (RENIS), ... -
Mercury, silver and selenium in serum before and after removal of amalgam restorations: results from a prospective cohort study in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-16)Objective A prospective cohort study on changes of health complaints after removal of amalgam restorations was carried out at the request of the Norwegian Directorate of Health. The aim was to provide and evaluate experimental treatment to patients with health complaints attributed to dental amalgam fillings. <p><p>Methods Patients (n = 32) with medically unexplained physical symptoms (MUPS), which ... -
Reducing unwarranted variation: can a ‘clinical dashboard’ be helpful for hospital executive boards and top-level leaders?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-23)Background/aim: In the past decades, there has been an increasing focus on defining, identifying and reducing unwarranted variation in clinical practice. There have been several attempts to monitor and reduce unwarranted variation, but the experience so far is that these initiatives have failed to reach their goals. In this article, we present the initial process of developing a safety, quality and ... -
Measuring socioeconomic position in studies of health inequalities
(Doctoral thesis; Doktorgradsavhandling, 2024-02-08)<p>There is a consistent finding that the higher the socioeconomic position (SEP), the better the health. The choice of SEP indicator is crucial in explaining these socioeconomic inequalities. However, a poorly motivated use of SEP indicators prevails in the literature on social health inequalities, hampering the transparency and comparability across studies. Its primary aim is to explore different ... -
Validation of forearm fracture diagnoses in administrative patient registers
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-24)Summary The validity of forearm fracture diagnoses recorded in fve Norwegian hospitals was investigated using image reports and medical records as gold standard. A relatively high completeness and correctness of the diagnoses was found. Algorithms used to define forearm fractures in administrative data should depend on study purpose.<p> <p>Purpose In Norway, forearm fractures are routinely recorded ... -
Association of C-reactive protein with future development of diabetes: A population-based 7-year cohort study among Norwegian adults aged 30 and older in the Tromsø Study 2007-2016
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-29)Objectives The extent to which observed associations between high-sensitivity C-reactive protein (hs-CRP) and incident diabetes are explained by obesity and hypertension remains unclear. This study aimed to investigate the association of hs-CRP with developing diabetes in a Norwegian general population sample.<p> <p>Design A cohort study using two population-based surveys of the Tromsø Study: ... -
The Norwegian registry for spine surgery (NORspine): cohort profile
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-17)Purpose - To review and describe the development, methods and cohort of the lumbosacral part of the Norwegian registry for spine surgery (NORspine).<p> <p>Methods - NORspine was established in 2007. It is government funded, covers all providers and captures consecutive cases undergoing operations for degenerative disorders. Patients’ participation is voluntary and requires informed consent. A set ... -
Associations of inner retinal layers with risk of incident dementia: An individual participant data analysis of four prospective cohort studies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-08)INTRODUCTION - Our main objective was to investigate whether retinal neurodegeneration, estimated from lower thickness of inner retinal layers, was associated with incident all-cause dementia and Alzheimer's disease (AD).<p> <p>METHODS - We performed an individual participant data meta-analysis using unpublished data from four prospective cohort studies with a total of 69,955 participants (n = ... -
Diagnostic accuracy of anti-3-[<sup>18</sup>F]-FACBC PET/MRI in gliomas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-30)Purpose - The primary aim was to evaluate whether anti-3-[<sup>18</sup>F]FACBC PET combined with conventional MRI correlated better with histomolecular diagnosis (reference standard) than MRI alone in glioma diagnostics. The ability of anti-3-[<sup>18</sup>F]FACBC to differentiate between molecular and histopathological entities in gliomas was also evaluated.<p> <p>Methods - In this prospective ... -
Baseline Demographics, Comorbidities, Treatment Patterns and Burden of Atopic Dermatitis in Adults and Adolescents from the GLOBOSTAD Long-Term Observational Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-06)Introduction - Insights into real-world treatment of atopic dermatitis (AD) are relevant to clinical decision making. The aim of this analysis was to characterize patients who receive dupilumab for AD in a real-world setting.<p> <p>Methods - The GLOBOSTAD registry is an ongoing, longitudinal, prospective, observational study of patients with AD who receive dupilumab according to country-specific ... -
Baroreflex sensitivity following acute upper-body exercise in the cold among stable coronary artery disease patients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-13)Background: A cold environment and exercise separately affect the autonomic nervous system (ANS), baroreflex sensitivity (BRS), and blood pressure variability (BPV) but their combined effects on post-exercise recovery are not known. Our cross-over trial examined these responses following upper-body static and dynamic exercise performed in a cold and neutral environment in patients with coronary ... -
Prospective randomized clinical studies involving reirradiation: update of a systematic review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-27)Background Reirradiation is a potentially useful option for many patients with recurrent cancer, aiming at cure or symptom palliation, depending on disease/recurrence type and stage. The purpose of this follow-up study to a previous review from 2016 was to summarize all recently published randomized trials. Points of interest again included identifcation of methodological strengths and weaknesses, ... -
Childhood trauma and outcome trajectories in patients with longstanding eating disorders across 17 years
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-27)Background: A large proportion of patients with eating disorders (ED) report experiences of childhood trauma. Latent trajectory analysis in ED samples reveals the complexities in course and outcome and can explore the long-term impact of adverse experiences in childhood.<p> <p>Method: A total of 84 patients with longstanding ED were included. ED symptoms were assessed by the Eating Disorder ... -
Activity-Based Protein Profiling in Methicillin-Resistant Staphylococcus aureus Reveals the Broad Reactivity of a Carmofur-Derived Probe
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-08)Activity-based protein profiling is a powerful chemoproteomic technique to detect active enzymes and identify targets and off-targets of drugs. Here, we report the use of carmofur- and activity-based probes to identify biologically relevant enzymes in the bacterial pathogen Staphylococcus aureus. Carmofur is an anti-neoplastic prodrug of 5-fluorouracil and also has antimicrobial and anti-biofilm ...