Liver X receptors (LXRs) are nuclear transcription factors important in the regulation of cholesterol transport, and glucose and fatty acid metabolism. The antiproliferative role of LXRs has been studied in a variety of malignancies and may represent a therapeutic opportunity in cancers lacking targeted therapies, such as triple-negative breast cancer. In this study, we investigated the impact of ...

Leukotriene B4 (LTB4) is linked to osteoarthritis (OA) development however the expression of LTB4 receptors in cartilage cells and the physiological effects of LTB4 on cartilage tissue remain unknown. In this study we find that human articular chondrocytes express LTB4 receptors and that these receptors are functional, however, LTB4 does not seem to affect importantly some primary chondrocyte functions.

Liposomes solubilize lipophilic drugs in the phospholipid membrane, and entrap hydrophilic drugs in its aqueous core. These vesicles provide a sustained- and targeted- drug release, and protect from degradation. Liposomes retain the drug onto/in the skin and improve skin drug deposition. Due to their liquid nature, a secondary vehicle, such as a hydrogel, is needed to obtain a necessary retention ...

Studies have revealed differing perceptions of risk associated with use of conventional and alternative treatments among medical doctors and CAM users. This pilot study explored such differing risk perceptions and their possible influence on doctor CAM user communication.

<p>Exposure training and behavioral experiments are common and well-supported mechanisms in cognitive behavioral therapy (CBT) for anxiety and depression in children. Virtual reality (VR) technology applies computer-generated, three-dimensional virtual environments, which have the potential to create realistic situations that can be repeated and rehearsed several times. Virtual environments, therefore, ...

Introduction Adherence to healthy lifestyle recommendations has positive effects on cancer outcomes yet adherence is low among cancer survivors. Differences in adherence between women and men, phase of survivorship, and other factors that might increase adherence, like the use of traditional and complementary medicine (T&CM), need to be explored. We aimed to study the adherence to national recommendations ...

Background and objective: Gallbladder cancer (GBC) is a rare malignancy in the Nordic countries and no common Nordic treatment guidelines exist. This study aimed to characterize the current diagnostic and treatment strategies in the Nordic countries and disclose differences in these strategies. Methods: This was a survey study with a cross-sectional questionnaire of all 19 university hospitals ...