Det helsevitenskapelige fakultet: Nye registreringer
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Investigating the relationship between allocentric spatial working memory and biomarker status in preclinical and prodromal Alzheimer’s disease.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-08)The 4 Mountain Test (4MT) is a test of allocentric spatial working memory and has been proposed as an earlier marker of predementia Alzheimer’s disease (AD) than episodic verbal memory. We here compare the 4MT to the CERAD word list memory recall in both cognitively normal (CN) and mild cognitive impairment (MCI) cases with or without cerebrospinal fluid markers (CSF) of Alzheimer’s disease ... -
S100A8 gene copy number and protein expression in breast cancer: associations with proliferation, histopathological grade and molecular subtypes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-14)Background and aims Amplification of S100A8 occurs in 10–30% of all breast cancers and has been linked to poorer prognosis. Similarly, the protein S100A8 is overexpressed in a roughly comparable proportion of breast cancers and is also found in infiltrating myeloid-lineage cells, again linked to poorer prognosis. We explore the relationship between these findings.<p> <p>Methods We examined S100A8 ... -
Is the presence of foraminal stenosis associated with outcome in lumbar spinal stenosis patients treated with posterior microsurgical decompression
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-05)Background We aim to investigate associations between preoperative radiological findings of lumbar foraminal stenosis with clinical outcomes after posterior microsurgical decompression in patients with predominantly central lumbar spinal stenosis (LSS).<p> <p>Methods The study was an additional analysis in the NORDSTEN Spinal Stenosis Trial. In total, 230 men and 207 women (mean age 66.8 (SD ... -
The Norwegian degenerative spondylolisthesis and spinal stenosis (NORDSTEN) study: study overview, organization structure and study population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-03)Purpose To provide an overview of the The Norwegian Degenerative spondylolisthesis and spinal stenosis (NORDSTEN)- study and the organizational structure, and to evaluate the study population.<p> <p>Methods The NORDSTEN is a multicentre study with 10 year follow-up, conducted at 18 public hospitals. NORDSTEN includes three studies: (1) The randomized spinal stenosis trial comparing the impact of ... -
Samene i Norge: Hvordan kan barnevernet ta hensyn til samenes rettigheter som urfolk?
(Chapter; Bokkapittel, 2019)Dette kapittelet handler om den samiske befolkningen i Norge og barnevernet. Formålet er å vise hvordan barnevernet kan ta hensyn til samenes rettigheter som urfolk. Samene er et urfolk i Norge. Gjennom norske og internasjonale lover har samene særlige rettigheter til å bevare sin kultur, identitet og språk. Disse rettighetene gjelder også når barn og familier mottar offentlige tjenester, slik som ... -
Candida auris
(Chapter; Bokkapittel, 2019)Candida auris (C. auris) er en gjærsopp som kan forårsake alvorlige infeksjoner hos mennesker. Infeksjoner med Candida auris forekommer i hovedsak i helseinstitusjoner og rammer som regel alvorlig syke pasienter. I tillegg er behandling vanskelig fordi soppen ofte er resistent/motstandsdyktig mot de vanligste medikamentene som brukes ved Candida-infeksjon. -
Vibrio vulnificus
(Chapter; Bokkapittel, 2019)<i>Vibrio vulnificus</i> er en bakterie som trives i saltvann over 20 grader og som kan gi sykdom hos personer med sår eller nedsatt immunforsvar (såkalt opportunistisk infeksjon). Alvorlige sykdom forekommer oftest nær Taiwan, Sør-Korea, Japan og i Mexicogolfen. I senere år er det rapportert flere tilfeller med alvorlige infeksjon med <i>Vibrio vulnificus</i> hos personer som har badet i nordiske ... -
Reply to Henriksen, S.; Rinaldo, C.H. Should SVGp12 Be Used for JC Polyomavirus Studies? Comment on “Prezioso et al. COS-7 and SVGp12 Cellular Models to Study JCPyV Replication and MicroRNA Expression after Infection with Archetypal and Rearranged-NCCR Viral Strains. Viruses 2022, 14, 2070”
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-29)In relation to the comment by Henriksen and Rinaldo, the authors intend to emphasize that before every experiment with SVGp12 cells they routinely test the cells for the absence of BKPyV contamination. The scientists can state that the SVGp12 cells used in their laboratory were not infected by BKPyV and that their results were also validated on the COS-7 cell line, which is permissive for JCPyV ... -
Functional analyses of rare germline BRCA1 variants by transcriptional activation and homologous recombination repair assays
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-21)Background - Damaging alterations in the BRCA1 gene have been extensively described as one of the main causes of hereditary breast and ovarian cancer (HBOC). BRCA1 alterations can lead to impaired homologous recombination repair (HRR) of double-stranded DNA breaks, a process which involves the RING, BRCT and coiled-coil domains of the BRCA1 protein. In addition, the BRCA1 protein is involved in ... -
Laterale ankelligamentskader
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-13)Laterale ankelligamentskader oppstår i forbindelse med inversjonstraumer og er en av de vanligste skadene både i den generelle befolkningen og blant aktive idrettsutøvere. En lateral ankelligamentskade svekker stabiliserende strukturer i ankelen og kan disponere for vedvarende instabilitet i ankelleddet. Akutte laterale ankelligamentskader uten mistanke om brudd kan behandles og følges opp konservativt ... -
Anti-apoptotic genes and non-coding RNAs are potential outcome predictors for ulcerative colitis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-18)Due to the lack of clinical, immunologic, genetic, and laboratory markers to predict remission in ulcerative colitis (UC) without relapse, there is no clear recommendation regarding withdrawal of therapy. Therefore, this study was to investigate if transcriptional analysis together with Cox survival analysis might be able to reveal molecular markers that are specific for remission duration and ... -
Internet Use for Obtaining Medicine Information: Cross-sectional Survey
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-22)Background: The internet is increasingly being used as a source of medicine-related information. People want information to facilitate decision-making and self-management, and they tend to prefer the internet for ease of access. However, it is widely acknowledged that the quality of web-based information varies. Poor interpretation of medicine information can lead to anxiety and poor adherence to ... -
Delay of Dental Care: An Exploratory Study of Procrastination, Dental Attendance, and Self-Reported Oral Health
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-20)Delay of dental care is a problem for dental public health. The present study explored the relationship between procrastination and dental attendance, focusing on delay in seeking dental care. This hypothetical relation was compared to other avoidance-related factors affecting dental attendance. In addition, an inquiry into the reasons for delaying dental care was conducted. Students (n = 164) ... -
Attitudes towards mathematics, achievement, and drop-out intentions among STEM and Non-STEM students in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-22)High mathematical ability is central in many domains. In the present study, we investigated relations between students’ high school mathematics background and current study program, and various mathematics-related outcomes. We expected that students who had attended higher-level mathematics courses in high school would report more positive attitudes towards mathematics and higher achievement in ... -
Dignity at stake – relatives’ experiences of influencing dignified care in nursing homes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-24)Background - Dignity, in the care of older nursing home residents, has been an increasingly part of the public discourse the recent years. Despite a growing body of knowledge about dignity and indignity in nursing homes, we have less knowledge of how relatives experience their role in this context. This study is a follow-up to a previous study in nursing homes, which gave rise to concern about the ... -
Glioblastom hos voksne
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-30)Glioblastom er den vanligste formen for primær hjernekreft hos voksne, og sykdommen har en alvorlig prognose. Selv om det er gjort store fremskritt i molekylær karakteristikk, har det ikke vært større gjennombrudd i behandlingen på mange år. Vi presenterer her en klinisk oversikt over dagens diagnostikk og behandling samt hvilke utfordringer og muligheter som ligger i å utvikle bedre og mer ... -
Cancer-associated fibroblasts in radiotherapy: Bystanders or protagonists?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-11)Background - The primary goal of radiotherapy (RT) is to induce cellular damage on malignant cells; however, it is becoming increasingly recognized the important role played by the tumor microenvironment (TME) in therapy outcomes. Therapeutic irradiation of tumor lesions provokes profound cellular and biological reconfigurations within the TME that ultimately may influence the fate of the ... -
Considerations regarding carotid artery dose in radiotherapy of the cervical spine
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-08)Radiation to the carotid arteries, e.g. in the context of head and neck cancer treatment, is one of several risk factors for artery stenosis. In principle, this fact may also have implications for stereotactic cervical spine radiotherapy, because long-term survival can be achieved in patients with oligometastatic disease and favorable prognostic features. Here, we suggest that radiation dose ... -
Educational interventions to ensure provision of doctors in rural areas - a systematic review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-10)Introduction: Recruiting doctors in rural areas is challenging. Various educational interventions have been introduced in many countries. This study aimed to explore undergraduate medical education interventions introduced to recruit doctors to rural areas, and the results of these interventions. Methods: We undertook a systematic search using search words 'rural', 'remote', 'workforce', 'physicians', ... -
Capacity-based legislation in Norway has so far scarcely influenced the daily life and responsibilities of patients' carers: a qualitative study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-20)Background - When capacity-based mental health legislation was introduced in Norway in 2017, there was concern about the consequences of change in the law for patients’carer whose community treatment order was revoked as a result of being assessed as having capacity to consent. The concern was that the lack of a community treatment order would increase carers’ responsibilities in an already challenging ...