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dc.contributor.authorHurler, Julia
dc.contributor.authorZakelj, Simon
dc.contributor.authorMravljak, Janez
dc.contributor.authorPajk, Stane
dc.contributor.authorKristl, Albin
dc.contributor.authorSchubert, Rolf
dc.contributor.authorSkalko-Basnet, Natasa
dc.date.accessioned2014-03-05T08:45:42Z
dc.date.available2014-03-05T08:45:42Z
dc.date.issued2013
dc.description.abstractTo study the release of liposome-associated drugs into hydrogels, we designed and synthesized two pH-sensitive rhodamine derivatives to use as model compounds of different lipophilicities. The dyes were fluorescent when in the free form released from liposomes into the chitosan hydrogel, but not when incorporated within liposomes. The effect of liposomal composition, surface charge and vesicle size on the release of those incorporated dyes was evaluated. The lipophilicity of the rhodamine derivatives affected both the amount and rate of release. While liposome size had only a minor effect on the release of dyes into the hydrogel, the surface charge affected the release to a greater extent. By optimizing the characteristics of liposomes we could develop a liposomes-in-hydrogel system for application in wound therapy. We further characterized liposomes-in-hydrogel for their rheological properties, textures and moisture handling, as well as their potential to achieve a controlled release of the dye. The polymer-dependent changes in the hydrogel properties were observed upon addition of liposomes. The charged liposomes exhibited stronger effects on the textures of the chitosan hydrogels than the neutral ones. In respect to the ability of the system to handle wound exudates, chitosan-based hydrogels were found to be superior to Carbopol-based hydrogels.en
dc.identifier.citationInternation Journal of Pharmaceutics 456(2013) nr. 1 s. 49-57en
dc.identifier.cristinIDFRIDAID 1049567
dc.identifier.doihttp://dx.doi.org/10.1016/j.ijpharm.2013.08.033
dc.identifier.issn0378-5173
dc.identifier.urihttps://hdl.handle.net/10037/5907
dc.identifier.urnURN:NBN:no-uit_munin_5602
dc.language.isoengen
dc.publisherElsevier Scienceen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Biopharmacy: 736en
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Biofarmasi: 736en
dc.subjectVDP::Mathematics and natural science: 400::Chemistry: 440::Pharmaceutical chemistry: 448en
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Kjemi: 440::Legemiddelkjemi: 448en
dc.titleThe effect of lipid composition and liposome size on the release properties of liposomes-in-hydrogelen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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