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dc.contributor.authorAndreassen, Monica
dc.contributor.authorRocca, Elena
dc.contributor.authorBøhn, Thomas
dc.contributor.authorWikmark, Odd Gunnar
dc.contributor.authorvan den Berg, Johnnie
dc.contributor.authorLøvik, Martinus
dc.contributor.authorTraavik, Terje
dc.contributor.authorNygaard, Unni Cecilie
dc.date.accessioned2015-03-02T07:21:21Z
dc.date.available2015-03-02T07:21:21Z
dc.date.issued2014
dc.description.abstractGenetically modified (GM) crops may bring new proteins with immunogenic and allergenic properties into the food and feed chains. The most commonly grown GM maize, MON810, expresses a modified version of the insecticidal Cry1Ab protein originating in the soil bacterium Bacillus thuringiensis(Bt). Immune reactions following inhalation of pollen and debris from such plants have been scarcely studied. We exposed BALB/c mice to purified Cry1Ab proteins and Cry1Ab-containing MON810 plant materials by intranasal installation. No anti-Cry1Ab antibodies were detected following exposure to the plant materials. Exposure to purified Cry1Ab resulted in specific antiCry1Ab IgG1 and IgE production, indicating inherent immunogenicity and allergenicity. Mice exposed to leaf extracts from both MON810 and unmodified maize demonstrated influx of lymphocytes and eosinophils in the broncho-alveolar lavage, and increased cytokine release in mediastinal lymph node cells. The results indicate that the airway exposure to Cry1Ab proteins may be a route of practical relevanceen_US
dc.identifier.citationFood and Agricultural Immunology, 2014, s.-en_US
dc.identifier.cristinIDFRIDAID 1226048
dc.identifier.doi10.1080/09540105.2014.988128
dc.identifier.issn0954-0105
dc.identifier.urihttps://hdl.handle.net/10037/7251
dc.identifier.urnURN:NBN:no-uit_munin_6852
dc.language.isoengen_US
dc.publisherTaylor & Francisen_US
dc.rights.accessRightsopenAccess
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Generell immunologi: 478en_US
dc.subjectVDP::Mathematics and natural science: 400::Basic biosciences: 470::General immunology: 478en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Generell mikrobiologi: 472en_US
dc.subjectVDP::Mathematics and natural science: 400::Basic biosciences: 470::General microbiology: 472en_US
dc.titleHumoral and cellular immune responses in mice after airway administration of Bacillus thuringiensis Cry1Ab and MON810 cry1Ab-transgenic maizeen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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