Fibroblast miR-210 overexpression is independently associated with clinical failure in Prostate Cancer – a multicenter (in situ hybridization) study
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https://hdl.handle.net/10037/10272Dato
2016-11-08Type
Journal articleTidsskriftartikkel
Peer reviewed
Forfatter
Andersen, Sigve; Richardsen, Elin; Moi, Line; Dønnem, Tom; Nordby, Yngve; Ness, Nora; Eilertsen Holman, Marte; Bremnes, Roy M.; Busund, Lill-ToveSammendrag
There is a need for better prognostication in prostate cancer (PC). “The micromanager of hypoxia”,
microRNA-210 (miR-210) is directly linked to hypoxia, is overexpressed in PC and has been implied
in tumor cell-fibroblast crosstalk. We investigated the prognostic impact of miR-210 in tumor cells
and fibroblasts in PC. Tumor and stromal samples from a multicenter PC cohort of 535 prostatectomy
patients were inserted into tissue microarrays. To investigate the expression of miR-210, we used in
situ hybridization and two pathologists semiquantitatively scored its expression. Overexpression
of miR-210 in tumor cells was not associated to biochemical failure-free survival (BFFS, p=0.85) or
clinical failure-free survival (CFFS, p=0.09). However, overexpression of miR-210 in fibroblasts was
significantly associated to a poor CFFS (p=0.001), but not BFFS (p=0.232). This feature was validated
in both cohorts. Overexpression of miR-210 was independently associated with a reduced CFFS
(HR=2.76, CI 95% 1.25–6.09, p=0.012). Overexpression of miR-210 in fibroblasts is independently
associated with a poor CFFS. This highlights the importance of fibroblasts and cellular compartment
crosstalk in PC. miR-210 is a candidate prognostic marker and potential therapeutic target in PC.
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This article is also available via DOI:10.1038/srep36573
This article is also available via DOI:10.1038/srep36573