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dc.contributor.authorHanno, Therese von
dc.contributor.authorLade, Anette Caroline
dc.contributor.authorMathiesen, Ellisiv B.
dc.contributor.authorPeto, Tunde
dc.contributor.authorNjølstad, Inger
dc.contributor.authorBertelsen, Geir
dc.date.accessioned2017-03-08T08:21:13Z
dc.date.available2017-03-08T08:21:13Z
dc.date.issued2016-12-18
dc.description.abstractPurpose: To provide sex-stratified normative data on retinal thickness and study the relationship with sex, age and refractive status. Methods: Population-based study including 2617 women and 1891 men, aged 38– 87 (mean 61 8) years, without diabetes, glaucoma and retinal diseases, and spherical equivalent refraction (SER) within 6 dioptres. Retinal thickness was measured with optical coherence tomography (spectral domain Cirrus HD-OCT). <br>Results: Women had thinner retina than men. Retinal thickness was significantly associated with refraction, where mean change in retinal thickness per 1Dincrease in SER was 1.3 (0.2) lm in the fovea, 0.7 (0.1) lm in the pericentral ring and 1.4 (0.1) lm in the peripheral ring. In the fovea, there was a non-monotonic curved relationship between retinal thickness and age in both sexes with a maximum at about 60 years (p < 0.001). In the pericentral ring, the mean reduction in retinal thickness per 10-year increase was 2.7 (0.3) lm in women and 4.0 (0.4) lm in men and corresponding results in the peripheral ring were 2.3 (0.3) lmin women and 2.6 (0.4) lmin men. In both regions, there was evidence for a nonlinear pattern with an increased rate of change with higher age. There was a significant interaction between sex and age for retinal thickness of the pericentral ring (p = 0.041). <br>Conclusion: Women had thinner retina than men, and thickness varied with refractive status. Retinal thickness was associated with age in all macular regions, and the rate of change in retinal thickness varied at different ages.en_US
dc.descriptionPublished version. Source at <a href=http://dx.doi.org/10.1111/aos.13337> http://dx.doi.org/10.1111/aos.13337 </a>en_US
dc.identifier.citationHanno T, Lade AC, Mathiesen EB, Peto T, Njølstad i, Bertelsen G. Macular thickness in healthy eyes of adults (N=4508) and relation to sex, age and refraction: The Tromsø Eye Study (2007-08). Acta Ophthalmologica. 2016en_US
dc.identifier.cristinIDFRIDAID 1419972
dc.identifier.doi10.1111/aos.13337
dc.identifier.issn1755-375X
dc.identifier.issn1755-3768
dc.identifier.urihttps://hdl.handle.net/10037/10476
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalActa Ophthalmologica
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Oftalmologi: 754en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Ophthalmology: 754en_US
dc.subjectageen_US
dc.subjectepidemiologyen_US
dc.subjectoptical coherence tomographyen_US
dc.subjectpopulation baseden_US
dc.subjectrefractionen_US
dc.subjectretinaen_US
dc.subjectsexen_US
dc.titleMacular thickness in healthy eyes of adults (N=4508) and relation to sex, age and refraction: The Tromsø Eye Study (2007-08)en_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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