Insulin‐like growth factor‐I (IGF‐I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF‐I are associated with a higher risk of cancers at specific sites, including breast and prostate. No prospective study has examined the association between circulating IGF‐I concentrations ...

<i>Background</i>: BMI is known to be strongly associated with all-cause mortality, but few studies have been large enough to reliably examine associations between BMI and a comprehensive range of cause-specific mortality outcomes.<p> <p><i>Methods</i>: In this population-based cohort study, we used UK primary care data from the Clinical Practice Research Datalink (CPRD) linked to national ...

Culture-independent molecular techniques and advances in next generation sequencing (NGS) technologies make large-scale epidemiological studies on microbiota feasible. A challenge using NGS is to obtain high reproducibility and repeatability, which is mostly attained through robust amplification. We aimed to assess the reproducibility of saliva microbiota by comparing triplicate samples. The ...

The theory of breast cancer as a <i>child deficiency disease</i> is an <i>inversion of the current paradigm</i>, which considers fullterm pregnancies to be a protective factor and uses nulliparous women as the reference group. Instead, the theory of breast cancer as a child deficiency disease says that women with the highest parity (about 20, which is the limit of human fertility) are those with ...

<i>Aims</i>: Educational inequality in cardiovascular disease and in modifiable risk factors changes over time and between birth cohorts. We aimed to assess how cardiovascular disease risk factors mediate educational differences in premature cardiovascular disease mortality and how this varies over birth cohorts and sex.<p> <p><i>Methods</i>: We followed 360,008 40–45-year-olds born in the ...

<i>Aim</i>: To describe the characteristics of the patient with MI who is admitted to a hospital and to characterize the main diagnostic and treatment interventions in clinic.<p> <p><i>Material and methods</i>: This study is observational and the part of big international project. It includes a representative sample of patients with MI admitted to 16 clinics in 13 regions of Russian Federation ...

<p><i>Objectives - </i>To evaluate a modified Global Trigger Tool (GTT) method with manual review of automatic triggered records to measure adverse events. <p><i>Design - </i>A cross-sectional study was performed using the original GTT method as gold standard compared to a modified GTT method. <p><i>Setting - </i>Medium size hospital trust in Northern Norway. <p><i>Participants - </i>One thousand ...

<p><i>Objectives - </i>To investigate the impact of increasing sample of records reviewed bi-weekly with the Global Trigger Tool method to identify adverse events in hospitalised patients. <p><i>Design - </i>Retrospective observational study. <p><i>Setting - </i>A Norwegian 524-bed general hospital trust. <p><i>Participants - </i>1920 medical records selected from 1 January to 31 December ...

En god fastlegetjeneste er viktig, ikke minst der det er lang avstand til sykehus. I Nord-Norge er avstandene store, og gjennomsnittlig reisetid fra de 87 kommunesentra i Nord-Norge til nærmeste sykehus er 2 timer og 6 minutter. I denne artikkelen beskriver vi fastlegetjenesten i Nord-Norge samtidig som vi fokuserer på sentrale utfordringer som gjelder rekruttering av fastleger, det å få fastleger ...

<p><i>Background</i>: Human biomonitoring studies have demonstrated decreasing concentrations of many persistent organic pollutants (POPs) in years after emission peaks.</p> <p><i>Objectives</i>: To describe time trends of POPs in blood using four cross-sectional samples of 30 year olds from Tromsø, Norway across 1986–2007, and to compare the measured concentrations of polychlorinated biphenyl ...