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dc.contributor.authorNieder, Carsten
dc.contributor.authorDalhaug, Astrid
dc.contributor.authorHaukland, Ellinor
dc.contributor.authorMannsåker, Bård
dc.contributor.authorPawinski, Adam
dc.date.accessioned2018-03-12T12:25:27Z
dc.date.available2018-03-12T12:25:27Z
dc.date.issued2017-01-19
dc.description.abstractThe aim of this study was to reduce barriers that prevent implementation of evidence-based recommendations about single-fraction palliative radiotherapy (PRT) and to demonstrate that single-fraction PRT yields similar outcomes as long-course treatment (≥10 fractions) in patients with bone metastases from breast cancer. This retrospective study (2007–2014) included 118 Norwegian female patients. All patients received guideline-conform systemic therapy including bone-targeting agents. Median survival was 12.7 months. Long-course PRT was prescribed in 60% of patients, while 21% had PRT with a single fraction of 8 Gy to at least one target. Reirradiation rate was not significantly higher after 8 Gy (9%, compared to 5% after long-course PRT and 6% after 4 Gy x5). Patients with favorable baseline characteristics such as younger age and good performance status (PS) were significantly more likely to receive long-course PRT. Biological subtype and comorbidity did not correlate with fractionation. Prognosis was influenced by biological subtype, extra-skeletal disease extent, severe anemia and abnormal CRP. The limited need for reirradiation after single fraction PRT might encourage physicians to prescribe this convenient regimen, which would improve resource utilization. Even patients with PS3 had a median survival of 3 months, which indicates that they could experience worthwhile clinical benefit.en_US
dc.descriptionSource at <a href=https://doi.org/10.1080/22423982.2016.1270080> https://doi.org/10.1080/22423982.2016.1270080 </a>.en_US
dc.identifier.citationNieder, C., Dalhaug, A., Haukland, E., Mannsåker, B. & Pawinski, A. (2017). Contemporary radiooncological management of bone metastases from breast cancer: factors associated with prescription of different fractionation regimens (short or long course) in a rural part of North Norway with long travel distance. International Journal of Circumpolar Health, 76(1), 1-7.en_US
dc.identifier.cristinIDFRIDAID 1464407
dc.identifier.doi10.1080/22423982.2016.1270080
dc.identifier.issn1239-9736
dc.identifier.issn2242-3982
dc.identifier.urihttps://hdl.handle.net/10037/12291
dc.language.isoengen_US
dc.publisherTaylor & Francis Openen_US
dc.relation.journalInternational Journal of Circumpolar Health
dc.rights.accessRightsopenAccessen_US
dc.subjectBreast canceren_US
dc.subjectbone metastasesen_US
dc.subjectprognostic factorsen_US
dc.subjectradiotherapyen_US
dc.subjectpalliative therapyen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.titleContemporary radiooncological management of bone metastases from breast cancer: factors associated with prescription of different fractionation regimens (short or long course) in a rural part of North Norway with long travel distanceen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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