Introduction: Liposomes as drug delivery systems has been widely studied as a way to solubilize poorly soluble drugs, reduce side effects of chemotherapeutics and increase circulation time in vivo. Since the first descriptions of liposomes over 60 years ago, they have shown tendencies to shrink and swell when the external environment of the liposomes is altered. This phenomenon has been studied in ...

<i>Objective</i> - Although exercise is recommended in the treatment of axial spondyloarthritis (axSpa), the focus has been on flexibility, and the effect of high-intensity exercises is unknown. The purpose of this study was to investigate the effect of high-intensity exercises on fatigue, sleep, and mood in patients with axSpA.<br><br> <i>Methods</i> - In this secondary analysis of a randomized ...

<p>Background: The Artic University of Norway entered a partnership with a smelting plant to reduce the factory fume CO2-footprint by cultivation of microalgae (diatoms). The biomass produced from the microalgae is rich in lipids, proteins and pigments and can potentially function as fish feed for the aquaculture industry. Before the biomass can be utilized as e.g. fish feed, a thorough investigation ...

INTRODUCTION: Docetaxel (DOC) is a potent anticancer drug but has several limitations such as poor solubility. The currently commercially available formulation of DOC is limited by reported serious side effects which either is attributed to the drug itself or the solvent used. Nanomedicine has been used for improving the therapeutic outcome of several drugs, but so far there are none available with ...

Administering drug formulations to the vagina is a challenge since the vagina possesses “self-cleaning” features which allow trapping and rapid removing of foreign particles. Therefore, the residence time of drugs is often too short to offer a sufficient clinical effect. The aim of this project was to develop and optimize a liposomes-in-hydrogel system containing resveratrol for the local treatment ...

The rather limited success of translation from basic research to clinical application has been highlighted as a major issue in the nanomedicine field. To identify the factors influencing the applicability of nanosystems as drug carriers and potential nanomedicine, we focused on following their fate through fluorescence-based assays, namely flow cytometry and imaging. These methods are often used to ...

Transposons are genetic elements that change their intracellular genomic position by transposition and are spread horizontally between bacteria when located on plasmids. It was recently discovered that transposition from fully heterologous DNA also occurs in the course of natural transformation. Here, we characterize the molecular details and constraints of this process using the replicative transposon ...

Hydrogels as artificial biomaterial scaffolds offer a much favoured 3D microenvironment for tissue engineering and regenerative medicine (TERM). Towards biomimicry of the native ECM, polysaccharides from Nature have been proposed as ideal surrogates given their biocompatibility. In particular, derivatives from microbial sources have emerged as economical and sustainable biomaterials due to their ...

The persistence of <i>Staphylococcus aureus</i> has been accredited to its ability to escape immune response via host cell invasion. Despite the efficacy of many antibiotics against <i>S. aureus</i>, the high extracellular concentrations of conventional antibiotics required for bactericidal activity is limited by their low cellular accumulation and poor intracellular retention. While nanocarriers ...

An alert regarding an outbreak of carbapenem-resistant <i>Klebsiella pneumoniae</i> carrying <i>bla</i> _NDM-1 and <i>bla</i> _OXA-48 carbapenemase-encoding genes was sent by Germany to European Union (EU)/European Economic Area (EEA) countries in October 2019. Since only limited whole genome sequencing (WGS) data on <i>bla</i> _NDM-1- and <i>bla</i> _OXA-48-positive ...