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dc.contributor.authorSkaare, Helga
dc.contributor.authorSvensson, My Hanna Sofia
dc.contributor.authorJenssen, Trond Geir
dc.contributor.authorÅsberg, Anders
dc.contributor.authorSchmidt, Erik Berg
dc.contributor.authorChandra, Anupam
dc.contributor.authorUeland, Thor
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorHartmann, Anders
dc.contributor.authorEide, Ivar Anders
dc.date.accessioned2019-01-25T10:18:17Z
dc.date.available2019-01-25T10:18:17Z
dc.date.issued2018-04-24
dc.description.abstract<p><i>Objective</i>: The major n-6 polyunsaturated fatty acids linoleic acid (LA) and arachidonic acid (AA) play a role in inflammation and glucose metabolism, which could affect patient and renal transplant survival.</p> <p><i>Design and methods</i>: In this single center cohort study of 1988 Norwegian renal transplant recipients, we assessed associations between plasma levels of LA and AA at baseline, measured by gas chromatography, and patient and graft survival, as well as inflammation and cardiovascular risk markers.</p> <p><i>Results</i>: During follow-up (median of 9.6 years), 595 patients died and 805 renal transplants were lost, either due to recipient death or graft failure. In multivariable survival analysis, we found no associations with mortality for plasma levels of LA (hazard ratios: 0.99, 95% confidence intervals: 0.96-1.01) or AA (hazard ratios: 1.01, 95% confidence intervals: 0.96-1.06). No associations were found for cardiovascular mortality, overall graft loss, or death-censored graft loss. Plasma glucose, proglycemic marker chemerin, and proinflammatory marker growth differentiation factor 15 were inversely associated with plasma LA and positively associated with plasma AA levels in multivariable analysis.</i> <p><i>Conclusions</i>: We found no associations between plasma levels of LA or AA and patient or graft survival. Plasma levels of LA and proglycemic indices were inversely associated, signaling a possible beneficial effect of LA consumption for prevention of posttransplantation diabetes mellitus.</p>en_US
dc.descriptionAccepted manuscript version, licensed <a href=http://creativecommons.org/licenses/by-nc-nd/4.0/> CC BY-NC-ND 4.0.</a> Published version available at <a href=https://doi.org/10.1053/j.jrn.2018.02.008> https://doi.org/10.1053/j.jrn.2018.02.008</a>.en_US
dc.identifier.citationSkaare, H., Svensson, M.H.S., Jenssen, T.G., Åsberg, A., Schmidt, E.B., Chandra, A., ... Eide, I.A. (2018). Plasma n-6 Polyunsaturated Fatty Acid Levels and Survival in Renal Transplantation. <i>Journal of renal nutrition, 28</i>(5), 333-339. https://doi.org/10.1053/j.jrn.2018.02.008en_US
dc.identifier.cristinIDFRIDAID 1592797
dc.identifier.doi10.1053/j.jrn.2018.02.008
dc.identifier.issn1051-2276
dc.identifier.issn1532-8503
dc.identifier.urihttps://hdl.handle.net/10037/14533
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalJournal of renal nutrition
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Nephrology, urology: 772en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nefrologi, urologi: 772en_US
dc.titlePlasma n-6 Polyunsaturated Fatty Acid Levels and Survival in Renal Transplantationen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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