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dc.contributor.authorMadssen, Torfinn Støve
dc.contributor.authorThune, Inger
dc.contributor.authorFlote, Vidar Gordon
dc.contributor.authorLundgren, Steinar
dc.contributor.authorBertheussen, Gro Falkener
dc.contributor.authorFrydenberg, Hanne
dc.contributor.authorWist, Erik
dc.contributor.authorSchlichting, Ellen
dc.contributor.authorSchäfer, Hartmut
dc.contributor.authorFjøsne, Hans Erikssønn
dc.contributor.authorVettukattil, Muhammad Riyas
dc.contributor.authorLømo, Jon
dc.contributor.authorBathen, Tone Frost
dc.contributor.authorGiskeødegård, Guro F.
dc.date.accessioned2019-02-21T10:29:23Z
dc.date.available2019-02-21T10:29:23Z
dc.date.issued2018-11-07
dc.description.abstract<p><i>Background</i>: Breast cancer treatment has metabolic side effects, potentially affecting risk of cardiovascular disease (CVD) and recurrence. We aimed to compare alterations in serum metabolites and lipoproteins during treatment between recipients and non-recipients of chemotherapy, and describe metabolite profiles associated with treatment-related weight gain.</p> <p><i>Methods</i>: This pilot study includes 60 stage I/II breast cancer patients who underwent surgery and were treated according to national guidelines. Serum sampled pre-surgery and after 6 and 12 months was analysed by MR spectroscopy and mass spectrometry. In all, 170 metabolites and 105 lipoprotein subfractions were quantified.</p> <p><i>Results</i>: The metabolite and lipoprotein profiles of chemotherapy recipients and non-recipients changed significantly 6 months after surgery (p < 0.001). Kynurenine, the lipid signal at 1.55–1.60 ppm, ADMA, 2 phosphatidylcholines (PC aa C38:3, PC ae C42:1), alpha-aminoadipic acid, hexoses and sphingolipids were increased in chemotherapy recipients after 6 months. VLDL and small dense LDL increased after 6 months, while HDL decreased, with triglyceride enrichment in HDL and LDL. At baseline, weight gainers had less acylcarnitines, phosphatidylcholines, lyso-phosphatidylcholines and sphingolipids, and showed an inflammatory lipid profile.</p> <p><i>Conclusion</i>: Chemotherapy recipients exhibit metabolic changes associated with inflammation, altered immune response and increased risk of CVD. Altered lipid metabolism may predispose for treatment-related weight gain.en_US
dc.description.sponsorshipThe South–East Norwegian Health Authority Active Against Cancer-Gjensidige Siftelsen The Norwegian Cancer Societyen_US
dc.descriptionAccepted manuscript version. Published version available at <a href=https://doi.org/10.1038/s41416-018-0211-x> https://doi.org/10.1038/s41416-018-0211-x</a>.en_US
dc.identifier.citationMadssen, T.S., Thune, I., Flote, V.G., Lundgren, S., Bertheussen, G.F., Frydenberg, H.W. ... Giskeødegård, G.F. (2018). Metabolite and lipoprotein responses and prediction of weight gain during breast cancer treatment. <i>British Journal of Cancer, 119</i>(9), 1144-1154. https://doi.org/10.1038/s41416-018-0211-xen_US
dc.identifier.cristinIDFRIDAID 1644447
dc.identifier.doi10.1038/s41416-018-0211-x
dc.identifier.issn0007-0920
dc.identifier.issn1532-1827
dc.identifier.urihttps://hdl.handle.net/10037/14738
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalBritish Journal of Cancer
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/KLINISK/213997/Norway/Insulin, lipids and Breast Cancer in a Randomised Clinical Trial. The Energy and Balance Aspects studies (EBBA I +II)//en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.titleMetabolite and lipoprotein responses and prediction of weight gain during breast cancer treatmenten_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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