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dc.contributor.authorSmåbrekke, Birgit
dc.contributor.authorBalteskard Rinde, Ludvig
dc.contributor.authorEvensen, Line Holtet
dc.contributor.authorMorelli, Vania Maris
dc.contributor.authorHveem, Kristian
dc.contributor.authorGabrielsen, Maiken Elvestad
dc.contributor.authorNjølstad, Inger
dc.contributor.authorMathiesen, Ellisiv B.
dc.contributor.authorRosendaal, Frits Richard
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.contributor.authorHansen, John-Bjarne
dc.date.accessioned2020-01-29T13:53:48Z
dc.date.available2020-01-29T13:53:48Z
dc.date.issued2019-05-24
dc.description.abstract<i>Background</i>: Family history of myocardial infarction (FHMI) is known to increase the risk of venous thromboembolism (VTE).<p> <p><i>Objectives</i>: To investigate the effect of prothrombotic genotypes on the association between FHMI and VTE in a case‐cohort recruited from a general population.<p> <p><i>Methods</i>: Cases with a first VTE (<i>n</i> = 1493) and a subcohort (<i>n</i> = 13 072) were sampled from the Tromsø study (1994‐2012) and the Nord‐Trøndelag health (HUNT) study (1995‐2008). The DNA samples were genotyped for rs8176719 (<i>ABO</i>), rs6025 (<i>F5</i>), rs1799963 (<i>F2</i>), rs2066865 (<i>FGG</i>), and rs2036914 (<i>F11</i>). Participants with missing information on risk alleles (<i>n</i> = 175), FHMI (<i>n</i> = 2769), and BMI (<i>n</i> = 52) were excluded. Cox regression models were used to estimate hazard ratios (HRs) with 95% confidence intervals (CI) for VTE. To explore the role of prothrombotic genotypes for the association between FHMI and VTE, we (a) included the genotypes in the multivariable‐adjusted models and (b) assessed the joint effects between FHMI and genotypes on VTE risk.<p> <p><i>Results</i>: The FHMI was associated with a 1.3‐fold increased risk of VTE (HR 1.32, 95% CI 1.16‐1.50) and 1.5‐fold increased risk of unprovoked VTE (HR 1.47, 95% CI 1.22‐1.78). The risk of VTE by FHMI did not alter after adjustment for the five genotypes. The combination of FHMI and the different prothrombotic genotypes did not result in an excess VTE risk (i.e. no biological interaction).<p> <p<<i>Conclusions</i>: Our findings suggest that the risk of VTE by FHMI is not explained by rs8176719 (<i>ABO</i>), rs6025 (<i>F5</i>), rs1799963 (<i>F2</i>), rs2066865 (<i>FGG</i>), and rs2036914 (<i>F11</i>). The combination of FHMI with prothrombotic genotypes had an additive effect on VTE risk.en_US
dc.descriptionThis is the peer reviewed version of the following article: Småbrekke, B., Rinde, L., Evensen, L., Morelli, V., Hveem, K., Gabrielsen, M., ... Hansen, J. (2019). Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism. <i>Journal of Thrombosis and Haemostasis, 17</i>(8), 1363-1371., which has been published in final form at <a href= https://doi.org/10.1111/jth.14493>https://doi.org/10.1111/jth.14493</a> . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en_US
dc.identifier.citationSmåbrekke B, Balteskard Rinde LBR, Evensen L, Morelli VM, Hveem K, Gabrielsen ME, Njølstad i, Mathiesen EB, Rosendaal FR, Brækkan SK, Hansen JB. Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism. Journal of Thrombosis and Haemostasis. 2019:1-9en_US
dc.identifier.cristinIDFRIDAID 1700766
dc.identifier.doi10.1111/jth.14493
dc.identifier.issn1538-7933
dc.identifier.issn1538-7836
dc.identifier.urihttps://hdl.handle.net/10037/17265
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalJournal of Thrombosis and Haemostasis
dc.relation.projectIDStiftelsen Kristian Gerhard Jebsen: SKGJ-MED-015en_US
dc.relation.projectIDNorges forskningsråd: 248817en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/BEHANDLING/248817/Norway/National training initiative to make better use of biobanks and health registry data//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holder© 2019 International Society on Thrombosis and Haemostasisen_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleImpact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolismen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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